Reactome | GIT1 [cytosol]

GIT1 [cytosol]

Stable Identifier

R-HSA-430326

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser for interactor UniProt:Q9H7E9 CH033

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External Reference Information

External Reference

UniProt:Q9Y2X7 GIT1

Gene Names

GIT1

Chain

chain:1-761

Reference Genes

BioGPS Gene:28964 GIT1

COSMIC (genes):GIT1 GIT1

CTD Gene:28964 GIT1

dbSNP Gene:28964 GIT1

ENSEMBL:ENSG00000108262 GIT1

HGNC:4272 GIT1

KEGG:hsa:28964 GIT1

Monarch:28964 GIT1

NCBI Gene:28964 GIT1

OMIM:608434 GIT1

UCSC:Q9Y2X7 GIT1

Reference Transcript

Other Identifiers

11717653_a_at

11752140_x_at

11754464_x_at

16842999

218030_PM_at

218030_at

28964

3751542

3751543

3751544

3751545

3751546

3751547

3751548

3751549

3751550

3751551

3751552

3751553

3751554

3751555

3751556

3751557

3751558

3751559

3751560

3751561

3751562

3751563

3751564

3751565

3751566

3751567

3751568

3751569

3751570

3751571

3751572

3751576

3751577

3751579

3751580

43805_f_at

65952_at

8013923

A_23_P100912

A_24_P347946

A_33_P3401673

GE58546

GO:0000922

GO:0001957

GO:0005096

GO:0005515

GO:0005737

GO:0005739

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005925

GO:0007420

GO:0007626

GO:0008092

GO:0008277

GO:0014069

GO:0016020

GO:0030027

GO:0031267

GO:0032012

GO:0032465

GO:0032691

GO:0036465

GO:0042995

GO:0043005

GO:0043015

GO:0043226

GO:0044305

GO:0044877

GO:0045202

GO:0045454

GO:0045820

GO:0046872

GO:0048013

GO:0048666

GO:0048856

GO:0050877

GO:0061743

GO:0070161

GO:0071222

GO:0090063

GO:0097431

GO:0098772

GO:0098793

GO:0098794

GO:0099171

GO:0106015

GO:2000300

HMNXSV003048269

ILMN_1733155

PH_hs_0024106

TC17001320.hg

g7661711_3p_at

g7661711_3p_x_at

Participates

as a candidate of

as an input of

SFKs phosphorylate GIT1 (Homo sapiens)

as a component of

Other forms of this molecule

p-Y383-GIT1 [cytosol]

Inferred To

GIT1 [cytosol] (Bos taurus)

GIT1 [cytosol] (Canis familiaris)

GIT1 [cytosol] (Gallus gallus)

GIT1 [cytosol] (Sus scrofa)

git-1 [cytosol] (Caenorhabditis elegans)

Git1 [cytosol] (Mus musculus)

Git1 [cytosol] (Rattus norvegicus)

Git [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001078923.1, NP_054749.2

OpenTargets

ENSG00000108262

ENSEMBL

ENST00000225394, ENST00000394869, ENSP00000378338, ENSP00000225394

HPA

ENSG00000108262-GIT1

PRO

Q9Y2X7

Pharos - Targets

Q9Y2X7

GlyGen

Q9Y2X7

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.822	8
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524)	0.802	5
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.744	7
UniProt:Q13153 PAK1	5	p-S144,T423-PAK1 [cytosol] (R-HSA-399819) PAK1 [cytosol] (R-HSA-162629) Active PAK1 [cytosol] (R-HSA-8964622) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) PAK1 [plasma membrane] (R-HSA-3928409)	0.744	5
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.68	5
UniProt:O60925 PFDN1	1	PFDN1 [cytosol] (R-HSA-379541)	0.667	4
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.659	4
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.615	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.602	10
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.569	4
UniProt:P49023 PXN	4	p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.564	3
UniProt:Q14161 GIT2	1	GIT2 [cytosol] (R-HSA-446034)	0.564	2
UniProt:O43504 LAMTOR5	1	LAMTOR5 [lysosomal membrane] (R-HSA-5655441)	0.553	2
UniProt:Q9H7E9 CH033			0.553	2
UniProt:P30519 HMOX2	3	HMOX2 [endoplasmic reticulum membrane] (R-HSA-189391) HMOX2 [specific granule membrane] (R-HSA-6799628) HMOX2 [plasma membrane] (R-HSA-6799676)	0.553	2
UniProt:P41220 RGS2	1	RGS2 [plasma membrane] (R-HSA-939787)	0.553	2
UniProt:Q15052 ARHGEF6	1	ARHGEF6 [cytosol] (R-HSA-195017)	0.547	3
UniProt:P16333 NCK1	2	NCK1 [plasma membrane] (R-HSA-202992) NCK1 [cytosol] (R-HSA-197954)	0.527	4
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.527	3
UniProt:Q16566 CAMK4	4	CAMK4 [cytosol] (R-HSA-57900) CAMK4 [nucleoplasm] (R-HSA-112280) p-T200-CAMK4 [nucleoplasm] (R-HSA-9619155) p-S12,S13,T200-CAMK4 [nucleoplasm] (R-HSA-111902)	0.527	2
UniProt:Q12873 CHD3	2	CHD3 [nucleoplasm] (R-HSA-4657012) monoSUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372)	0.508	2
UniProt:Q5T3J3 LRIF1			0.508	2
UniProt:Q99728 BARD1	13	K6PolyUb,p-T714,T734-BARD1 [nucleoplasm] (R-HSA-9707286) p-T714,T734-BARD1 [nucleoplasm] (R-HSA-5659846) BARD1 [nucleoplasm] (R-HSA-5659775) K6PolyUb-BARD1 [nucleoplasm] (R-HSA-9701024) BARD1 C83G [nucleoplasm] (R-HSA-9699139) BARD1 C50G [nucleoplasm] (R-HSA-9699137) BARD1 L44R [nucleoplasm] (R-HSA-9699126) BARD1 H68Y [nucleoplasm] (R-HSA-9699151) BARD1 W34R [nucleoplasm] (R-HSA-9699166) BARD1 G623W [nucleoplasm] (R-HSA-9699148) BARD1 C53W [nucleoplasm] (R-HSA-9700807) BARD1 C71Y [nucleoplasm] (R-HSA-9700808) BARD1 G623E [nucleoplasm] (R-HSA-9699135)	0.508	2
UniProt:Q9P2H0 CE126			0.508	2
UniProt:P49024 PAXI			0.499	3
UniProt:P25098 GRK2	4	GRK2 [plasma membrane] (R-HSA-50270) p-S29-ADRBK1 [plasma membrane] (R-HSA-111969) ADRBK1 [cilium] (R-HSA-5632504) p-S29-ADRBK1 [cytosol] (R-HSA-9645318)	0.463	5

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