Reactome | ARHGEF7 [cytosol]

ARHGEF7 [cytosol]

Stable Identifier

R-HSA-430346

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Beta-Pix, PIX, COOL1

Locations in the PathwayBrowser for interactor UniProt:Q14161 GIT2

Expand all

External Reference Information

External Reference

UniProt:Q14155 ARHGEF7

Gene Names

ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB, Nbla10314

Chain

initiator methionine:, initiator methionine:, chain:1-803

Reference Genes

BioGPS Gene:8874 ARHGEF7

COSMIC (genes):ARHGEF7 ARHGEF7

CTD Gene:8874 ARHGEF7

dbSNP Gene:8874 ARHGEF7

ENSEMBL:ENSG00000102606 ARHGEF7

ENSEMBL_homo_sapiens_GENE:ENSG00000102606.20 ARHGEF7

HGNC:15607 ARHGEF7

KEGG Gene (Homo sapiens):8874 ARHGEF7

Monarch:8874 ARHGEF7

NCBI Gene:8874 ARHGEF7

OMIM:605477 ARHGEF7

UCSC:Q14155 ARHGEF7

Reference Transcript

Other Identifiers

11723129_a_at

11723130_a_at

11726073_a_at

11726074_a_at

11752571_a_at

11752845_a_at

11752846_x_at

16776537

202547_PM_s_at

202547_s_at

202548_PM_s_at

202548_s_at

229642_PM_at

229642_at

242999_PM_at

242999_at

3501660

3501662

3501663

3501672

3501673

3501674

3501675

3501678

3501685

3501690

3501695

3501698

3501704

3501707

3501708

3501709

3501714

3501721

3501722

3501723

3501724

3501727

3501728

3501731

3501732

3501736

3501737

3501739

3501740

3501741

3501742

3501743

3501744

3501745

3501746

3501747

3501748

3501749

3501750

40828_at

69169_at

7970111

81222_at

8874

A_14_P109119

A_23_P321855

A_23_P417891

A_33_P3288904

D63476_at

GE57273

GE647512

GE809705

GO:0001726

GO:0005085

GO:0005515

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005925

GO:0005938

GO:0007010

GO:0007030

GO:0007155

GO:0007165

GO:0007266

GO:0007399

GO:0008092

GO:0010763

GO:0012501

GO:0019901

GO:0023052

GO:0030027

GO:0030032

GO:0032991

GO:0034330

GO:0035556

GO:0042995

GO:0043005

GO:0043015

GO:0043025

GO:0043065

GO:0043226

GO:0043547

GO:0048013

GO:0048041

GO:0048856

GO:0048870

GO:0065003

GO:0070161

GO:0097431

GO:0098772

GO:0098794

GO:1900026

GO:1905833

GO:2000394

HMNXSV003022798

HMNXSV003023162

Hs.117494.0.S1_3p_at

Hs.172813.0.A1_3p_a_at

Hs.201919.0.A1_3p_at

ILMN_1675984

ILMN_1796912

ILMN_1798587

ILMN_2235679

PH_hs_0010346

TC13000398.hg

TC13001303.hg

g4505572_3p_a_at

Participates

as a candidate of

as an input of

GIT1 binds bPIX (Homo sapiens)

as a component of

as a member of

GEFs [cytosol] (Homo sapiens)

Inferred To

pix-1 [cytosol] (Caenorhabditis elegans)

Arhgef7 [cytosol] (Mus musculus)

Arhgef7 [cytosol] (Rattus norvegicus)

Ghost homologue of ARHGEF7 [cytosol] (Danio rerio)

arhgef7 [cytosol] (Xenopus tropicalis)

ARHGEF7 [cytosol] (Bos taurus)

ARHGEF7 [cytosol] (Canis familiaris)

ARHGEF7 [cytosol] (Gallus gallus)

ARHGEF7 [cytosol] (Sus scrofa)

RtGEF [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001317527.1, NP_003890.1, NP_001307782.1, NP_001317526.1, NP_001307780.1, NP_001106985.1, NP_001106984.1, NP_001106983.1, NP_663788.1, NP_001307783.1, XP_016876314.1, XP_016876313.1

OpenTargets

ENSG00000102606

HPA

ENSG00000102606-ARHGEF7

GeneCards

Q14155

Ensembl

ENSP00000397068, ENST00000375739, ENSP00000325994, ENSP00000364888, ENST00000375741, ENST00000426073, ENSP00000364875, ENSP00000364893, ENSG00000102606, ENST00000317133, ENSP00000364891, ENST00000375723, ENST00000375736

PRO

Q14155

Pharos - Targets

Q14155

HMDB Protein

HMDBP11481

PDB

1ZSG, 1BY1, 2L3G, 5SXP

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13153 PAK1	5	PAK1 [plasma membrane] (R-HSA-3928409) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) Active PAK1 [cytosol] (R-HSA-8964622) PAK1 [cytosol] (R-HSA-162629) p-S144,T423-PAK1 [cytosol] (R-HSA-399819)	0.953	16
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.936	21
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.822	8
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.813	5
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653)	0.81	8
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.715	7
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.676	8
UniProt:Q14161 GIT2	1	GIT2 [cytosol] (R-HSA-446034)	0.669	5
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.643	3
UniProt:P60953-2 CDC42			0.623	3
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.591	9
UniProt:O60880-1 SH2D1A			0.581	5
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.569	4
UniProt:P50222 MEOX2			0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
GTP [ChEBI:15996]	7	GTP [cilium] (R-ALL-5617813) GTP [early endosome membrane] (R-ALL-2130170) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [Golgi membrane] (R-ALL-1806221)	0.544	2
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.527	3
UniProt:P16333 NCK1	2	NCK1 [cytosol] (R-HSA-197954) NCK1 [plasma membrane] (R-HSA-202992)	0.527	4
UniProt:P49023 PXN	4	p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.527	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.527	3
UniProt:Q15052 ARHGEF6	1	ARHGEF6 [cytosol] (R-HSA-195017)	0.527	4
UniProt:P41227 NAA10			0.524	3
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.508	2
UniProt:Q13191 CBLB	1	CBLB [cytosol] (R-HSA-976009)	0.508	2
UniProt:P30153 PPP2R1A	2	PPP2R1A [nucleoplasm] (R-HSA-165968) PPP2R1A [cytosol] (R-HSA-165982)	0.499	3
UniProt:Q7Z6B7 SRGAP1	1	SRGAP1 [cytosol] (R-HSA-428453)	0.499	4
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.483	3

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