MigFilin associates with Filamin and F-actin

Stable Identifier
R-HSA-430347
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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MigFilin associates with Filamin and F-actin
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Migfilin associates with actin filaments as a result of its interaction with filamin (Tu et al., 2003). Migfilin associates with actin filaments and loss of migfilin decreases the level of F-actin suggesting that, in addition to providing an anchoring site for actin filaments at cell-ECM adhesions, migfilin also functions in the regulation of filamin-mediated cross-linking and stabilization of actin filaments (Tu et al., 2003).
Literature References
PubMed ID Title Journal Year
12679033 Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation

Shi, X, Tu, Y, Chen, K, Wu, C, Wu, S

Cell 2003
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Orthologous Events
MigFilin associates with Filamin and F-actin (Bos taurus)
MigFilin associates with Filamin and F-actin (Caenorhabditis elegans)
MigFilin associates with Filamin and F-actin (Canis familiaris)
MigFilin associates with Filamin and F-actin (Dictyostelium discoideum)
MigFilin associates with Filamin and F-actin (Drosophila melanogaster)
MigFilin associates with Filamin and F-actin (Mus musculus)
MigFilin associates with Filamin and F-actin (Rattus norvegicus)
MigFilin associates with Filamin and F-actin (Sus scrofa)
MigFilin associates with Filamin and F-actin (Xenopus tropicalis)
Authored
Matthews, L  (2009-10-12)
Reviewed
Wu, C  (2009-11-12)
Created
Matthews, L  (2009-08-06)
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