Aquaporin-6 passively transports anions out of vesicles

Stable Identifier
R-HSA-432036
Type
Reaction [transition]
Species
Homo sapiens
Compartment
transport vesicle membrane, cytosol, transport vesicle
ReviewStatus
5/5
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Aquaporin-6 passively transports anions out of vesicles
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Aquaporin-6 (AQP6) passively transports anions across membranes. Rat AQP6 has been shown to transport anions, with the highest permeability for nitrate, the lowest permeability for fluoride, and low permeability for water. In rat AQP6 is expressed in the acid-secreting type-A intercalated cells of renal ducts where it co-localizes with the proton-ATPase in the membranes of intracellular vesicles. AQP6 is gated by low pH.
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

anion channel activity of AQP6 tetramer [transport vesicle membrane]

Physical Entity
AQP6 tetramer [transport vesicle membrane] (Homo sapiens)
Activity
anion channel activity (GO:0005253)
Inferred From
Passive Transport of Anions out of Vesicles by Aquaporin-6 (rat) (Rattus norvegicus)
Cross References
Rhea
Authored
May, B  (2009-08-07)
Reviewed
Beitz, E  (2010-06-24)
Mathai, JC  (2010-07-31)
MacIver, B  (2010-07-31)
Calamita, G  (2010-07-15)
Created
May, B  (2009-08-09)
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