p-S256-Aquaporin-2 passively transports water into cell

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Aquaporin-2 (AQP2) passively transports water across membranes according to the osmotic gradient. AQP2 is mainly expressed in principal cells of the collecting duct and connecting tubule in the kidney. AQP2 function is acutely regulated by the antidiuretc hormone vasopressin. In the presence of vasopressin AQP is phosphorylated at Ser256, As inferred from rat and mouse Ser261, Ser264, and Thr269 may also be phosphorylated. These phosphorylations are thought to influence AQP2 trafficking and compartmentalization.
Literature References
PubMed ID Title Journal Year
11076974 The subcellular localization of an aquaporin-2 tetramer depends on the stoichiometry of phosphorylated and nonphosphorylated monomers

van Os, CH, Deen, PM, Kamsteeg, EJ, Heijnen, I

J Cell Biol 2000
7510718 Cloning, characterization, and chromosomal mapping of human aquaporin of collecting duct

Nakajima, K, Saito, H, Kuwahara, M, Ishibashi, K, Saito, F, Inui, K, Uchida, S, Ikeuchi, T, Sasaki, S, Fushimi, K

J Clin Invest 1994
19144687 Role of multiple phosphorylation sites in the COOH-terminal tail of aquaporin-2 for water transport: evidence against channel gating

Fenton, RA, MacAulay, N, Moeller, HB, Knepper, MA

Am J Physiol Renal Physiol 2009
9829975 Bidirectional water fluxes and specificity for small hydrophilic molecules in aquaporins 0-5

Meinild, AK, Zeuthen, T, Klaerke, DA

J Biol Chem 1998
8140421 Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine

van Os, CH, Deen, PM, Wieringa, B, Knoers, NV, van Oost, BA, Verdijk, MA, Monnens, LA

Science 1994
7535000 Water channel expression in human ADPKD kidneys

Perrone, RD, Bachinsky, DR, Emmanouel, DS, Jefferson, DM, Sabolic, I, Brown, D, Carone, FA

Am J Physiol 1995
15703994 Distribution of AQP2 and AQP3 water channels in human tissue microarrays

Marples, D, Wray, S, Mobasheri, A

J Mol Histol 2005
Catalyst Activity

water channel activity of p-S256-AQP2 tetramer [plasma membrane]

Orthologous Events
Cross References
Cite Us!