Aquaporin-4 passively transports water out of cell

Stable Identifier
Reaction [transition]
Homo sapiens
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Aquaporin-4 (AQP4) passively transports water across the plasma membrane according to the osmotic gradient. AQP4 is expressed in the collecting duct of the kidney and in astroglial cells at the blood-brain barrier and ependymal cells lining the ventricles of the brain.
Literature References
PubMed ID Title Journal Year
19383790 Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance

Miercke, LJ, Sandstrom, A, Robbins, RA, Stroud, RM, Ho, JD, Chorny, I, Harries, WE, Yeh, R

Proc Natl Acad Sci U S A 2009
19170255 Distribution of the AQP4 water channel in normal human tissues: protein and tissue microarrays reveal expression in several new anatomical locations, including the prostate gland and seminal vesicles

Marples, D, Moskaluk, CA, Young, IS, Floyd, RV, Frigeri, A, Mobasheri, A

Channels (Austin) 2007
17178220 Identification of arylsulfonamides as Aquaporin 4 inhibitors

Nakada, T, Sakimura, K, Huber, VJ, Tsujita, M, Yamazaki, M

Bioorg Med Chem Lett 2007
18511455 Novel variants in human Aquaporin-4 reduce cellular water permeability

Sorani, MD, Giacomini, KM, Zador, Z, Hurowitz, E, Yan, D, Manley, GT

Hum Mol Genet 2008
14514735 Aquaporin expression in normal human kidney and in renal disease

Walker, RJ, Bedford, JJ, Leader, JP

J Am Soc Nephrol 2003
8855281 The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain

Lu, M, Lee, MD, Deen, PM, Verdijk, MA, Merkx, G, Jung, JS, Rijss, JP, Agre, P, Smith, BL

Proc Natl Acad Sci U S A 1996
Catalyst Activity

water channel activity of AQP4 tetramer [plasma membrane]

Orthologous Events
Cross References
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