Aquaporin-7 passively transports glycerol out of cell

Stable Identifier
Reaction [transition]
Homo sapiens
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Aquaporin-7 (AQP7) passively transports glycerol and water across the plasma membrane according to the osmotic gradient. AQP7 is expressed in adipocytes under the direct control of the PPARG and RXRA nuclear receptors. Expression of AQP7 correlates with release of glycerol from adipocytes. AQP7 is seen to translocate from the nuclear periphery to the plasma membrane during adrenaline-stimulated lipolysis. In rat AQP7 also transports urea.
Literature References
PubMed ID Title Journal Year
9405233 Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability

Ishida, N, Matsuzawa, Y, Mita, S, Matsubara, K, Okubo, K, Ohno, I, Kuriyama, H, Kawamoto, S

Biochem Biophys Res Commun 1997
18555844 Comparison of messenger RNA distribution for 60 proteins in fat cells vs the nonfat cells of human omental adipose tissue

Tichansky, DS, Bahouth, SW, Madan, AK, Buehrer, B, Fain, JN

Metabolism 2008
11952783 Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation

Kondo, H, Nakamura, T, Kishida, K, Kuriyama, H, Kihara, S, Shimomura, I, Kurachi, Y, Maeda, N, Makino, Y, Nagaretani, H, Nishizawa, H, Matsuda, M, Matsuzawa, Y, Funahashi, T

Eur J Biochem 2002
16325777 Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers

Marrades, MP, Martinez, JA, Milagro, FI, Moreno-Aliaga, MJ

Biochem Biophys Res Commun 2006
17961083 A current view of the mammalian aquaglyceroporins

Praetorius, J, Rojek, A, Fenton, RA, Nielsen, S, Fr√łkiaer, J

Annu Rev Physiol 2008
Catalyst Activity

glycerol channel activity of AQP7 tetramer [plasma membrane]

Orthologous Events
Cross References
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