Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding

Stable Identifier
R-HSA-432110
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
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The binding of SHC to integrin alpha IIb beta 3 is blocked by phosphorylation of beta 3 at Thr-779, or by substitution of this residue for Asp. PDK1 and Akt1/PKB-alpha both specifically target Thr-779 in in vitro assays.

Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of AKT1/PDK1 [plasma membrane]

Physical Entity
AKT1/PDK1 [plasma membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Bos taurus)
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Caenorhabditis elegans)
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Canis familiaris)
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Danio rerio)
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Drosophila melanogaster)
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Gallus gallus)
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Mus musculus)
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Rattus norvegicus)
Authored
Akkerman, JW  (2009-09-04)
Reviewed
Heemskerk, JW  (2010-09-01)
Created
Jupe, S  (2009-08-10)
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