Reactome | LRP8 [plasma membrane]

LRP8 [plasma membrane]

Stable Identifier

R-HSA-432113

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

ApoER2, Low-density lipoprotein receptor-related protein 8, Apolipoprotein E receptor 2, LRP8_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q14114 LRP8

Gene Names

LRP8, APOER2

Chain

signal peptide:1-32, chain:33-963

Reference Genes

BioGPS Gene:7804 Q141143

COSMIC (genes):LRP8 LRP8

CTD Gene:7804 Q141143

dbSNP Gene:7804 Q141143

ENSEMBL:ENSG00000157193 LRP8

HGNC:6700 Q141143

KEGG:hsa:7804 Q141143

Monarch:7804 Q141143

NCBI Gene:7804 Q141143

OMIM:602600 Q141143

UCSC:Q14114 Q141143

Reference Transcript

Participates

as a member of

LRPs [plasma membrane] (Homo sapiens)

as an input of

LDL binds to LRP8 (Homo sapiens)

as a component of

LDL:LRP8 [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-Y-LRP8 [plasma membrane]

Inferred To

Lrp8 [plasma membrane] (Rattus norvegicus)

LRP8 [plasma membrane] (Bos taurus)

LRP8 [plasma membrane] (Canis familiaris)

LRP8 [plasma membrane] (Gallus gallus)

LRP8 [plasma membrane] (Mus musculus)

LRP8 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_004622.2, NP_150643.2, NP_001018064.1, NP_059992.3

ENSEMBL

ENST00000347547, ENST00000371454, ENST00000306052, ENSP00000303634, ENSP00000360509, ENSP00000346391, ENSG00000157193, ENSP00000334522, ENST00000354412

OpenTargets

ENSG00000157193

GeneCards

LRP8

HPA

ENSG00000157193-LRP8

PRO

Q14114

Pharos - Targets

Q14114

GlyGen

Q14114

PDB

3A7Q, 5B4X, 5B4Y, 7UCX

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q60841	1	RELN [extracellular region] (R-MMU-8854469)	0.769	10
UniProt:P30533 AMRP			0.564	2
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.558	2
UniProt:P35968 KDR	5	p-6Y-VEGFR2 [plasma membrane] (R-HSA-4420103) VEGFR2 [plasma membrane] (R-HSA-195382) p-Y801,Y1054,Y1175-KDR [plasma membrane] (R-HSA-9860484) VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane] (R-HSA-9673613) p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane] (R-HSA-9673636)	0.471	2

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