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Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor
Stable Identifier
R-HSA-432172
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Unblocking of NMDA receptors, glutamate binding and activation (Homo sapiens)
Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
NMDA receptors require binding of two ligands: agonist, glutamate and co-agonist, glycine or D-serine. The extracellular ligand binding domain in GluN1 (GRIN1, NR1) subunits binds co-agonist glycine or D-serine and the extracellular ligand binding domain in GluN2 (GRIN2, NR2) binds glutamate. In total, two molecules of glycine or D-serine (one for each of the two GluN1 subunits) and two molecules of glutamate (one for each of the two GluN2 subunits) are bound to activate one NMDA receptor (Kleckner and Dingledine 1988, Benveniste and Mayer 1991, Furukawa et al. 2005).
Participants
Input
x 2
Gly,D-Ser [extracellular region]
GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane]
(Homo sapiens)
x 2
L-Glu [extracellular region]
Output
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane]
(Homo sapiens)
Participates
as an event of
Unblocking of NMDA receptors, glutamate binding and activation (Homo sapiens)
Inferred From
Glycine and glutamate ligands bind Grin1:Grin2a NMDA receptor (Rattus norvegicus)
Authored
Mahajan, SS (2009-10-29)
Reviewed
Tukey, D (2009-11-18)
Hansen, KB (2018-11-02)
Yi, F (2018-11-02)
Created
Mahajan, SS (2009-08-12)
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