Reactome | Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)

Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)

Stable Identifier

R-HSA-432232

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, transport vesicle membrane

ReviewStatus

5/5

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Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)

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Activated Protein Kinase A phosphorylates Aquaporin-2 at Serine 256. The phosphorylated form of AQP2 then traffics from intracellular vesicles to the apical plasma membrane.

Literature References

PubMed ID	Title	Journal	Year
9227644	Protein kinase A phosphorylation is involved in regulated exocytosis of aquaporin-2 in transfected LLC-PK1 cells Katsura, T, Gustafson, CE, Ausiello, DA, Brown, D	Am J Physiol	1997
12194985	The role of putative phosphorylation sites in the targeting and shuttling of the aquaporin-2 water channel Hofman, E, Deen, PM, van der Sluijs, P, Savelkoul, PJ, Markovich, D, Nielsen, S, van Balkom, BW	J Biol Chem	2002