Reactome | NEFL [cytosol]

NEFL [cytosol]

Stable Identifier

R-HSA-432284

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Neurofilament light polypeptide, NFL_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P13646 KRT13

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Assembly and cell surface presentation of NMDA receptors (Homo sapiens)
        
        GluN1 (GRIN1) binds to NEFL at postsynaptic density (Homo sapiens)
        
        NEFL [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P07196 NEFL

Gene Names

NEFL, NF68, NFL

Chain

initiator methionine:, chain:2-543

Reference Genes

BioGPS Gene:4747 NEFL

COSMIC (genes):NEFL NEFL

CTD Gene:4747 NEFL

dbSNP Gene:4747 NEFL

ENSEMBL:ENSG00000277586 NEFL

HGNC:7739 NEFL

KEGG:hsa:4747 NEFL

Monarch:4747 NEFL

NCBI Gene:4747 NEFL

OMIM:162280 NEFL

UCSC:P07196 NEFL

Reference Transcript

RefSeq:NM_006158.4 NEFL

Other Identifiers

11725928_s_at

11725929_a_at

11756778_x_at

17075589

221801_3p_x_at

221801_PM_x_at

221801_x_at

221805_PM_at

221805_at

221916_PM_at

221916_at

3128272

3128273

3128274

3128275

3128276

3128277

3128278

3128279

3128280

3128281

3128282

3128283

3128284

3128285

3128286

3128287

3128288

3128289

3128290

3128291

3128292

3128293

40995_at

4747

51706_at

8149835

82720_at

A_23_P71492

A_24_P18137

A_33_P3287785

GE81601

GE87715

GO:0000226

GO:0005198

GO:0005200

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0005882

GO:0005883

GO:0007010

GO:0007018

GO:0007409

GO:0008089

GO:0008090

GO:0009636

GO:0012501

GO:0014012

GO:0019896

GO:0019904

GO:0021510

GO:0021766

GO:0021987

GO:0030424

GO:0030426

GO:0030674

GO:0031133

GO:0031594

GO:0033693

GO:0040011

GO:0042802

GO:0042995

GO:0043005

GO:0043226

GO:0043274

GO:0043434

GO:0044877

GO:0045105

GO:0045109

GO:0045110

GO:0045111

GO:0048812

GO:0048856

GO:0050772

GO:0050877

GO:0050885

GO:0051258

GO:0051412

GO:0060052

GO:0060090

GO:0065003

GO:0090128

GO:0097049

GO:0098685

GO:0098981

GO:0099160

GO:0099170

GO:0099182

GO:0099184

GO:0099185

GO:1903935

GO:1903937

GO:1904115

GO:2000672

HMNXSV003010205

Hs.211584.0.A2_3p_at

Hs.211584.0.A3_3p_x_at

Hs.302689.1.S1_3p_at

ILMN_1659086

TC08001068.hg

X05608_at

Participates

as a component of

as an input of

GluN1 (GRIN1) binds to NEFL at postsynaptic density (Homo sapiens)

Inferred To

Homologues of NEFL [cytosol] (Danio rerio)

Nefl [cytosol] (Mus musculus)

Nefl [cytosol] (Rattus norvegicus)

neflb [cytosol] (Danio rerio)

nefl [cytosol] (Xenopus tropicalis)

Ghost homologue of NEFL [cytosol] (Caenorhabditis elegans)

Ghost homologue of NEFL [cytosol] (Drosophila melanogaster)

NEFL [cytosol] (Bos taurus)

NEFL [cytosol] (Canis familiaris)

NEFL [cytosol] (Gallus gallus)

NEFL [cytosol] (Sus scrofa)

neff2 [cytosol] (Danio rerio)

Cross References

RefSeq

NP_006149.2

OpenTargets

ENSG00000277586

ENSEMBL

ENSP00000482169, ENST00000610854

HPA

ENSG00000277586-NEFL

PRO

P07196

Pharos - Targets

P07196

GlyGen

P07196

Orphanet

NEFL

Interactors (110)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.85	11
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.844	6
UniProt:P17661 DES	1	DES [cytosol] (R-HSA-390570)	0.831	8
UniProt:P07197 NFM			0.742	6
UniProt:P12757 SKIL	1	SKIL [nucleoplasm] (R-HSA-2186596)	0.718	6
UniProt:Q9H7C4 SYNCI			0.666	5
UniProt:P25815 S100P	2	S100P [extracellular region] (R-HSA-6804809) S100P [secretory granule lumen] (R-HSA-6804782)	0.666	4
UniProt:Q99608 NDN	1	NDN [nucleoplasm] (R-HSA-6789966)	0.666	4
UniProt:Q8IUI8 CRLF3			0.556	3
UniProt:Q96LL4 CH048			0.556	3
UniProt:Q96MN9-2 Q96MN92			0.556	3
UniProt:Q86TJ2-3 Q86TJ23			0.556	3
UniProt:Q7Z417 NUFP2			0.556	3
UniProt:Q96JP2 MY15B			0.556	3
UniProt:P21281 ATP6V1B2	1	ATP6V1B2 [cytosol] (R-HSA-912598)	0.556	3
UniProt:Q9P2K3-2 RCOR3			0.556	3
UniProt:Q86V28 Q86V28			0.556	3
UniProt:P45880 VDAC2	6	p-S65-Ub:VDAC2 [mitochondrial outer membrane] (R-HSA-9834982) K63polyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-9843314) K48polyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-9843321) Ub-VDAC2 [mitochondrial outer membrane] (R-HSA-9835025) VDAC2 [mitochondrial outer membrane] (R-HSA-5696880) PolyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-6783185)	0.556	3
UniProt:Q6ZU52 K0408			0.556	3
UniProt:Q9C0F3 ZNF436	1	ZNF436 [nucleoplasm] (R-HSA-1247538)	0.556	3
UniProt:Q8NI37 PPTC7			0.556	3
UniProt:P13646 KRT13	1	KRT13 [cytosol] (R-HSA-6809591)	0.556	3
UniProt:Q9UGJ1-2 TUBGCP4			0.556	3
UniProt:Q7Z3I7 ZN572			0.556	3
UniProt:Q8IZU1 FAM9A			0.556	3
UniProt:P13928 ANXA8			0.556	3
UniProt:O15535 ZSC9			0.556	3
UniProt:Q9Y5P3 RAI2			0.556	3
UniProt:Q15049 MLC1			0.556	3
UniProt:Q6NYC8 PPR18			0.556	3
UniProt:P58304 VSX2			0.556	3
UniProt:Q14847-2 LASP1			0.556	3
UniProt:Q9BQQ3 GORASP1	4	GORASP1 [Golgi membrane] (R-HSA-6808767) p-S189,T216,S274,S373-GORASP1 [Golgi membrane] (R-HSA-2314415) GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-162984) p-T216,S274,S373-GORASP1 [Golgi membrane] (R-HSA-2172182)	0.556	3
UniProt:P63172 DYNLT1	3	DYNLT1 [ficolin-1-rich granule lumen] (R-HSA-6801487) DYNLT1 [extracellular region] (R-HSA-6806509) DYNLT1 [secretory granule lumen] (R-HSA-6801497)	0.556	3
UniProt:Q53FD0-2 ZC2HC1C			0.556	3
UniProt:Q96LB9 PGLYRP3	1	PGLYRP3 [extracellular region] (R-HSA-6799958)	0.556	3
UniProt:Q6P587-2 FAHD1			0.556	3
UniProt:Q6UXG2-3 ELAPOR1			0.556	3
UniProt:Q15776 ZKSCAN8	1	ZKSCAN8 [nucleoplasm] (R-HSA-974985)	0.556	3
UniProt:Q8IXL7-2 MSRB3			0.556	3
UniProt:Q9NS73-5 MBIP			0.556	3
UniProt:Q3KNS6-3 Q3KNS63			0.556	3
UniProt:P0C7W6 CC172			0.556	3
UniProt:Q8N5S9-2 Q8N5S92			0.556	3
UniProt:Q6X4W1-6 NSMF			0.556	3
UniProt:Q9H6S3 EPS8L2	1	EPS8L2 [cytosol] (R-HSA-9663247)	0.556	3
UniProt:P19012 KRT15	1	KRT15 [cytosol] (R-HSA-6809589)	0.556	3
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.556	3
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.556	3
UniProt:Q9NXC2 GFOD1	1	GFOD1 [plasma membrane] (R-HSA-9714882)	0.556	3
UniProt:Q9UJW8-4 ZNF180			0.556	3
UniProt:Q99932-2 SPAG8			0.556	3
UniProt:Q8IYE1 CCD13			0.556	3
UniProt:P51608 MECP2			0.556	3
UniProt:Q7L622 G2E3			0.556	3
UniProt:A2RU56 A2RU56			0.556	3
UniProt:Q96N77-2 ZNF641			0.556	3
UniProt:Q5VWN6 TASO2			0.556	3
UniProt:P05783 KRT18	1	KRT18 [cytosol] (R-HSA-201582)	0.556	3
UniProt:Q9HC98-4 NEK6			0.556	3
UniProt:Q494V2-2 CFAP100			0.556	3
UniProt:A0A1B0GWI1 A0A1B0GWI1			0.556	3
UniProt:Q9Y240 CLC11			0.556	3
IntAct:EBI-25843046 RZPDO834E1121D			0.556	3
UniProt:Q6P2R3 Q6P2R3			0.556	3
UniProt:Q7L576 CYFIP1	5	CYFIP1 [cytosol] (R-HSA-5672575) CYFIP1 [specific granule lumen] (R-HSA-6800167) CYFIP1 [extracellular region] (R-HSA-6800473) CYFIP1 [secretory granule lumen] (R-HSA-6800940) CYFIP1 [tertiary granule lumen] (R-HSA-6800176)	0.556	3
UniProt:Q9NR11-2 ZNF302			0.556	3
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.556	3
UniProt:Q96PK6 RBM14	1	RBM14 [nucleoplasm] (R-HSA-8938345)	0.556	3
UniProt:Q8NB12 SMYD1	1	SMYD1 [nucleoplasm] (R-HSA-5688412)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:Q16512 PKN1	3	p-T774-PKN1 [cytosol] (R-HSA-5623651) PKN1 [cytosol] (R-HSA-5623613) p-T774-PKN1 [nucleoplasm] (R-HSA-5625721)	0.556	3
UniProt:Q13569 TDG	3	TDG [nucleoplasm] (R-HSA-65812) monoSUMO1-K330-TDG [nucleoplasm] (R-HSA-4551718) polySUMO2,3-K330-TDG [nucleoplasm] (R-HSA-4551628)	0.556	3
UniProt:P08727 KRT19	1	KRT19 [cytosol] (R-HSA-6809617)	0.556	3
UniProt:Q8TC84 FANK1			0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
IntAct:EBI-25851697 CCSB			0.556	3
UniProt:Q5W5X9-3 TTC23			0.556	3
UniProt:Q9BRX2 PELO			0.556	3
UniProt:Q99504 EYA3	2	p-EYA3 [nucleoplasm] (R-HSA-5683979) EYA3 [nucleoplasm] (R-HSA-5683622)	0.556	3
UniProt:Q9Y5B8 NME7	1	NME7 [cytosol] (R-HSA-6806880)	0.556	3
UniProt:Q14525 KRT33B	1	KRT33B [cytosol] (R-HSA-6809594)	0.556	3
UniProt:Q14005-2 Q140052			0.556	3
UniProt:Q8TCX5 RHPN1	1	RHPN1 [cytosol] (R-HSA-5667017)	0.556	3
UniProt:Q9Y575-3 ASB3			0.556	3
UniProt:Q5VYS8-5 TUT7			0.556	3
UniProt:Q8TDR4 TCP1L			0.556	3
UniProt:Q53R41 FAKD1			0.556	3
UniProt:Q9NP61 ARFGAP3	1	ARFGAP3 [cytosol] (R-HSA-6807740)	0.556	3
UniProt:Q68EA5 ZNF57			0.556	3
UniProt:Q5TAQ9-2 Q5TAQ92			0.556	3
UniProt:O76041 NEBL			0.556	3
UniProt:Q8IUC2 KRTAP8-1	1	KRTAP8-1 [cytosol] (R-HSA-6810288)	0.556	3
UniProt:P20933 AGA	2	AGA [extracellular region] (R-HSA-6806212) AGA [azurophil granule lumen] (R-HSA-6798769)	0.556	3
UniProt:Q8N865 SMIP4			0.556	3
UniProt:Q8IXM2 BAP18			0.556	3
UniProt:Q9BQG1 SYT3			0.556	3
UniProt:Q6P597-2 KLC3			0.556	3
UniProt:O95817 BAG3	1	BAG3 [cytosol] (R-HSA-5255451)	0.556	3
UniProt:Q9P286 PAK5	2	PAK5 [cytosol] (R-HSA-428459) PAK7 [plasma membrane] (R-HSA-211555)	0.556	3
IntAct:EBI-16439879 CCSB ORF ID			0.556	3
UniProt:Q96DM3 RMC1			0.527	2
UniProt:Q15276 RABEP1	1	RABEP1 [early endosome membrane] (R-HSA-2029004)	0.527	2
UniProt:Q6ZRV2 FA83H			0.527	2
UniProt:Q96DX4 RSPRY			0.527	2
UniProt:P54274 TERF1	1	TERF1 [nucleoplasm] (R-HSA-164618)	0.508	2
UniProt:Q13614 MTMR2	1	MTMR2 [cytosol] (R-HSA-1604662)	0.508	2
UniProt:P14079 TAX			0.488	4
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.483	2

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