Reactome | trans-Golgi Network Lysosomal Vesicle Scission

trans-Golgi Network Lysosomal Vesicle Scission

Stable Identifier

R-HSA-432707

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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trans-Golgi Network Lysosomal Vesicle Scission

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Dynamin is recruited to the growing lysosome destined vesicle and, under conditions that interfere with its GTPase activity, dynamin forms a collar or ring around the neck of the budding vesicle. It is unclear whether dynamin acts as a mechanochemical transducer to generate fission or as a recruiter to attach other proteins that are directly responsible for the fission step. Lipid-modifying enzymes such as endophilin are also involved in vesicle formation. Endophilin is an acyltransferase that interacts with dynamin and that generates lysophosphatidic acid. The current view is that this reaction produces a negative curvature at the neck of the vesicle.

Literature References

PubMed ID	Title	Journal	Year
11994746	Regulated transport of the glucose transporter GLUT4. James, DE, Bryant, NJ, Govers, R	Nat Rev Mol Cell Biol	2002
11604418	Generation of high curvature membranes mediated by direct endophilin bilayer interactions Rose, K, Floyd, SR, Ringstad, N, Farsad, K, Takei, K, De Camilli, P	J Cell Biol	2001
8670264	Dynamin II binds to the trans-Golgi network Knoblich, M, Maier, O, Westermann, P	Biochem Biophys Res Commun	1996