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ILK [cytosol]
Stable Identifier
R-HSA-432864
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Integrin-linked protein kinase, ILK_HUMAN
Locations in the PathwayBrowser for interactor UniProt:O00165 HAX1
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-extracellular matrix interactions (Homo sapiens)
Formation of the PINCH-ILK-parvin complex (Homo sapiens)
ILK [cytosol] (Homo sapiens)
Localization of the PINCH-ILK-PARVIN complex to focal adhesions (Homo sapiens)
ILK interacts with beta-1 integrin (Homo sapiens)
ILK [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13418 ILK
Gene Names
ILK, ILK1, ILK2
Chain
chain:1-452
Reference Genes
BioGPS Gene:3611 ILK
COSMIC (genes):ILK ILK
CTD Gene:3611 ILK
dbSNP Gene:3611 ILK
ENSEMBL:ENSG00000166333 ILK
HGNC:6040 ILK
KEGG:hsa:3611 ILK
Monarch:3611 ILK
NCBI Gene:3611 ILK
OMIM:602366 ILK
UCSC:Q13418 ILK
Reference Transcript
RefSeq:NM_001014795.2 ILK
RefSeq:NM_001014794.2 ILK
RefSeq:XM_005252905.2 ILK
RefSeq:NM_004517.3 ILK
RefSeq:XM_005252904.4 ILK
RefSeq:NM_001278441.1 ILK
RefSeq:XM_011520065.1 ILK
RefSeq:NM_001278442.1 ILK
Other Identifiers
11724913_s_at
16721479
201234_PM_at
201234_at
3318891
3318892
3318893
3318894
3318895
3318896
3318897
3318898
3318900
3318901
3318902
3318903
3318904
3318905
3318906
3318907
3318908
3318909
3318910
3318911
3318912
3318913
3318914
3318915
3318916
35365_at
3611
7938154
A_14_P102901
A_14_P107440
A_14_P124609
A_23_P105066
A_24_P406870
GE59135
GE615707
GE86727
GE88667
GO:0000902
GO:0001658
GO:0001725
GO:0001934
GO:0003151
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0005925
GO:0006355
GO:0006468
GO:0007155
GO:0007160
GO:0007163
GO:0007165
GO:0007229
GO:0008283
GO:0008284
GO:0009967
GO:0010761
GO:0014044
GO:0016020
GO:0016740
GO:0019901
GO:0021675
GO:0022011
GO:0030017
GO:0030027
GO:0030030
GO:0030513
GO:0033209
GO:0034446
GO:0042327
GO:0042995
GO:0043123
GO:0043491
GO:0045197
GO:0045669
GO:0045893
GO:0048856
GO:0048870
GO:0061351
GO:0070161
GO:0070527
GO:0090263
GO:0106310
GO:0140096
GO:1900026
GO:2000178
HMNXSV003056947
ILMN_1732827
ILMN_2358980
ILMN_2364376
TC11000133.hg
U40282_at
g4758605_3p_s_at
Participates
as a component of
ILK:Integrin beta-1 [plasma membrane] (Homo sapiens)
PINCH-ILK-parvin complex [cytosol] (Homo sapiens)
as an input of
ILK interacts with beta-1 integrin (Homo sapiens)
Formation of the PINCH-ILK-parvin complex (Homo sapiens)
Inferred To
Ilk [cytosol]
(Drosophila melanogaster)
pat-4 [cytosol]
(Caenorhabditis elegans)
ilk [cytosol]
(Danio rerio)
ilk [cytosol]
(Xenopus tropicalis)
ILK [cytosol]
(Bos taurus)
ILK [cytosol]
(Canis familiaris)
ILK [cytosol]
(Dictyostelium discoideum)
ILK [cytosol]
(Mus musculus)
ILK [cytosol]
(Rattus norvegicus)
ILK [cytosol]
(Sus scrofa)
Homologues of ILK [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001014795.1
,
NP_001014794.1
,
NP_004508.1
,
XP_011518367.1
,
NP_001265370.1
,
XP_005252961.1
,
XP_005252962.1
,
NP_001265371.1
Guide to Pharmacology - Targets
2041
OpenTargets
ENSG00000166333
ENSEMBL
ENST00000420936
,
ENSP00000299421
,
ENSP00000403487
,
ENSP00000435323
,
ENST00000528995
,
ENST00000396751
,
ENSP00000434492
,
ENST00000299421
,
ENST00000532063
,
ENSP00000379975
ZINC - Substances
ILK_HUMAN
ZINC target
Q13418
PRO
Q13418
GlyGen
Q13418
PDB
3KMW
,
3IXE
,
6MIB
,
3KMU
,
3F6Q
,
2KBX
,
3REP
,
4HI8
,
4HI9
IntEnz
2.7.11.1
HPA
ENSG00000166333-ILK
Pharos - Targets
Q13418
ZINC - Predictions - Purchasable
ILK_HUMAN
HMDB Protein
HMDBP01460
Interactors (56)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NVD7 PARVA
1
PARVA [cytosol]
(R-HSA-432848)
0.97
27
UniProt:P48059 LIMS1
1
LIMS1 [cytosol]
(R-HSA-432859)
0.961
18
UniProt:Q15404 RSU1
1
RSU1 [cytosol]
(R-HSA-446297)
0.899
9
UniProt:Q9HBI1 PARVB
1
PARVB [cytosol]
(R-HSA-446016)
0.886
8
UniProt:Q9HBI0 PARVG
0.871
14
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.725
4
UniProt:P27708 CAD
1
CAD [cytosol]
(R-HSA-73452)
0.725
4
UniProt:P40227 CCT6A
1
CCT6A [cytosol]
(R-HSA-390454)
0.725
4
UniProt:P48643 CCT5
1
CCT5 [cytosol]
(R-HSA-390447)
0.725
4
UniProt:P50991 CCT4
1
CCT4 [cytosol]
(R-HSA-390458)
0.725
4
UniProt:P50990 CCT8
5
CCT8 [secretory granule lumen]
(R-HSA-6801035)
CCT8 [extracellular region]
(R-HSA-6806238)
CCT8 [azurophil granule lumen]
(R-HSA-6799369)
CCT8 [ficolin-1-rich granule lumen]
(R-HSA-6800894)
CCT8 [cytosol]
(R-HSA-390449)
0.725
4
UniProt:P49368 CCT3
1
CCT3 [cytosol]
(R-HSA-390463)
0.725
4
UniProt:Q99832 CCT7
1
CCT7 [cytosol]
(R-HSA-390451)
0.725
4
UniProt:P49023 PXN
4
p-Y-PXN [plasma membrane]
(R-HSA-9031680)
PXN [plasma membrane]
(R-HSA-180493)
PXN [cytosol]
(R-HSA-210014)
p-Y31,Y118-PXN [cytosol]
(R-HSA-5218693)
0.669
4
UniProt:Q9NVI1 FANCI
3
FANCI [nucleoplasm]
(R-HSA-419529)
p-4S-FANCI [nucleoplasm]
(R-HSA-6788480)
MonoUb-K523,p-4S-FANCI [nucleoplasm]
(R-HSA-6785321)
0.669
3
UniProt:O60762 DPM1
4
DPM1 R92G [endoplasmic reticulum membrane]
(R-HSA-4717370)
DPM1 Q210Rfs*4 [endoplasmic reticulum membrane]
(R-HSA-4717361)
DPM1 G111Lfs*45 [endoplasmic reticulum membrane]
(R-HSA-4717383)
DPM1 [endoplasmic reticulum membrane]
(R-HSA-162865)
0.669
3
UniProt:P14373 TRIM27
2
TRIM27 [cytosol]
(R-HSA-8851002)
TRIM27 [nucleoplasm]
(R-HSA-2997690)
0.666
4
UniProt:Q6R327 RICTOR
1
RICTOR [cytosol]
(R-HSA-198632)
0.659
8
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.643
3
UniProt:P78527 PRKDC
4
PRKDC [nucleoplasm]
(R-HSA-62161)
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
(R-HSA-76302)
PRKDC [cytosol]
(R-HSA-3134816)
K48polyUb-PRKDC [cytosol]
(R-HSA-8938766)
0.643
3
UniProt:Q9BRK5 CAB45
0.643
3
UniProt:P16615 ATP2A2
2
ATP2A2 [platelet dense tubular network membrane]
(R-HSA-427903)
ATP2A2 [endoplasmic reticulum membrane]
(R-HSA-391962)
0.643
3
UniProt:Q92616 GCN1
1
GCN1 [cytosol]
(R-HSA-9633010)
0.643
3
UniProt:P78371 CCT2
3
CCT2 [azurophil granule lumen]
(R-HSA-6799356)
CCT2 [extracellular region]
(R-HSA-6806220)
CCT2 [cytosol]
(R-HSA-390464)
0.643
3
UniProt:Q9UMS6 SYNP2
0.611
6
UniProt:Q9BWU0 NADAP
0.602
7
UniProt:Q9NWT6 HIF1AN
1
HIF1AN [cytosol]
(R-HSA-1234154)
0.59
2
UniProt:Q13085 ACACA
2
ACACA [cytosol]
(R-HSA-1660609)
Btn-ACACA [cytosol]
(R-HSA-2976730)
0.564
2
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
0.564
2
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.564
2
UniProt:Q16531 DDB1
1
DDB1 [nucleoplasm]
(R-HSA-53489)
0.564
2
UniProt:P48059-3 LIMS1
0.556
3
UniProt:Q9NZ01 TECR
1
TECR [endoplasmic reticulum membrane]
(R-HSA-548663)
0.527
2
UniProt:P61619 SEC61A1
2
SEC61A1 [endoplasmic reticulum membrane]
(R-HSA-444591)
SEC61A1 [phagocytic vesicle membrane]
(R-HSA-1236813)
0.527
2
UniProt:O00165 HAX1
0.527
2
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.527
2
UniProt:P27361 MAPK3
6
p-T202,Y204-MAPK3 [nucleoplasm]
(R-HSA-112359)
p-T202,Y204-MAPK3 [cytosol]
(R-HSA-109842)
MAPK3 [cytosol]
(R-HSA-59284)
MAPK3 [nucleoplasm]
(R-HSA-73724)
p-T202-MAPK3 [cytosol]
(R-HSA-9635775)
MAPK3 [endoplasmic reticulum lumen]
(R-HSA-9636295)
0.527
3
UniProt:A1L0T0 HACL2
0.527
2
UniProt:Q8NE01 CNNM3
0.527
2
UniProt:P04439 HLA-A
9
HLA class I histocompatibility antigen, A-3 alpha chain precursor [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983100)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [Golgi membrane]
(R-HSA-983376)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [plasma membrane]
(R-HSA-197642)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [ER to Golgi transport vesicle membrane]
(R-HSA-983347)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [early endosome membrane]
(R-HSA-1236826)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [recycling endosome membrane]
(R-HSA-8863889)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [phagocytic vesicle membrane]
(R-HSA-1236740)
HLA-A A-3 [endoplasmic reticulum membrane]
(R-HSA-8943090)
K48polyUb-HLA-A A-2 [endoplasmic reticulum membrane]
(R-HSA-8943073)
0.527
2
UniProt:Q96EY1 DNJA3
0.527
2
UniProt:P05023 ATP1A1
1
ATP1A1 [plasma membrane]
(R-HSA-936850)
0.527
2
UniProt:Q8NF37 LPCAT1
3
LPCAT1 [plasma membrane]
(R-HSA-6806273)
LPCAT1 [azurophil granule membrane]
(R-HSA-6798758)
LPCAT1 [endoplasmic reticulum membrane]
(R-HSA-1498772)
0.527
2
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.527
2
UniProt:P36776 LONP1
1
LONP1 [mitochondrial matrix]
(R-HSA-9838000)
0.527
2
UniProt:P54652 HSPA2
2
HSPA2 [cytosol]
(R-HSA-3371408)
HSPA2 [nucleoplasm]
(R-HSA-912480)
0.527
2
UniProt:P49327 FASN
3
FASN [cytosol]
(R-HSA-54659)
decanoyl-FASN [cytosol]
(R-HSA-5655935)
FASN [cytosol]
(R-HSA-199233)
0.527
2
UniProt:Q9ULX6 AKAP8L
1
AKAP8L [nucleoplasm]
(R-HSA-9821364)
0.527
2
UniProt:Q13451 FKBP5
2
FKBP5 [nucleoplasm]
(R-HSA-8939165)
FKBP5 [cytosol]
(R-HSA-5618096)
0.527
2
UniProt:Q3ZCQ8 TIMM50
1
TIMM50 [mitochondrial inner membrane]
(R-HSA-1252070)
0.527
2
UniProt:Q14257 RCN2
0.527
2
UniProt:P00367 GLUD1
3
GLUD1 [mitochondrial matrix]
(R-HSA-70582)
RibC-GLUD1 [mitochondrial matrix]
(R-HSA-5688244)
Ack-GLUD1 [mitochondrial matrix]
(R-HSA-5688293)
0.527
2
UniProt:Q7Z4I7 LIMS2
1
LIMS2 [cytosol]
(R-HSA-446078)
0.527
2
UniProt:O95831 AIFM1
0.527
2
UniProt:Q9H0C8 ILKAP
0.508
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
2
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