CBL neddylates TGFBR2

Stable Identifier
R-HSA-4332236
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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CBL neddylates TGFBR2
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CBL neddylates TGFBR2 on lysine residues K556 and K567. The E3 ubiquitin ligase activity of CBL is necessary for this modification, and the kinase activity of TGFBR2 is also required. CBL-mediated neddylation prolongs the half-life of TGFBR2, thereby enhancing signaling by the TGF-beta receptor complex. CBLB, a CBL-related protein, may cooperate with CBL in TGFBR2 neddylation (Zuo et al. 2013).
Literature References
PubMed ID Title Journal Year
23290524 c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-? type II receptor

Chen, Y, Deng, H, Zuo, W, Zhang, T, Luo, S, Ding, Y, Gao, C, Feng, XH, Huang, F, Chen, YG, Du, J, Chiang, YJ, Jeong, LS, Lee, HW, Li, M

Mol. Cell 2013
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as an event of
Catalyst Activity

ubiquitin-protein transferase activity of TGFBR2:CBL [plasma membrane]

Physical Entity
TGFBR2:CBL [plasma membrane] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
CBL neddylates TGFBR2 (Bos taurus)
CBL neddylates TGFBR2 (Canis familiaris)
CBL neddylates TGFBR2 (Drosophila melanogaster)
CBL neddylates TGFBR2 (Gallus gallus)
CBL neddylates TGFBR2 (Mus musculus)
CBL neddylates TGFBR2 (Rattus norvegicus)
CBL neddylates TGFBR2 (Sus scrofa)
Authored
Orlic-Milacic, M  (2013-08-17)
Reviewed
Chen, YG  (2013-08-28)
Created
Orlic-Milacic, M  (2013-08-17)
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