Autophosphorylation and activation of CAMK2

Stable Identifier
R-HSA-4332363
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Autophosphorylation and activation of CAMK2
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Binding of CaM to CAMK2 displaces the autoinhibitory loop from the active site and allows CAMK2 to autophosphorylate T286, resulting in CAMK2 activation (reveiwed in Stratton et al, 2013).

Literature References
PubMed ID Title Journal Year
23632248 Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II

Schulman, H, Stratton, MM, Kuriyan, J, Chao, LH

Curr. Opin. Struct. Biol. 2013
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Output
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Catalyst Activity

protein serine/threonine kinase activity of CAMK2:CaM [cytosol]

Physical Entity
CAMK2:CaM [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Autophosphorylation and activation of CAMK2 (Bos taurus)
Autophosphorylation and activation of CAMK2 (Caenorhabditis elegans)
Autophosphorylation and activation of CAMK2 (Canis familiaris)
Autophosphorylation and activation of CAMK2 (Danio rerio)
Autophosphorylation and activation of CAMK2 (Drosophila melanogaster)
Autophosphorylation and activation of CAMK2 (Mus musculus)
Autophosphorylation and activation of CAMK2 (Rattus norvegicus)
Authored
Rothfels, K  (2013-08-17)
Reviewed
Kikuchi, A  (2013-11-13)
Created
Rothfels, K  (2013-08-17)
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