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NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3
Stable Identifier
R-HSA-433672
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Deacetylation of Histone H4 and Dimethylation of Lysine-9 of Histone H3 in Promoter of rRNA Gene
ReviewStatus
5/5
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Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Negative epigenetic regulation of rRNA expression (Homo sapiens)
NoRC negatively regulates rRNA expression (Homo sapiens)
NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 (Homo sapiens)
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As inferred from mouse cell models, histones in silenced rRNA gene copies are deacetylated by HDAC1 (and possibly HDAC2), which is part of the SIN3-HDAC complex bound to NoRC. The PHD domain of the TIP5 (BAZ2A) component of NoRC binds acetylated lysine-16 of histone H4. The residues of histone H4 that are deacetylatd are lysine-5, lysine-8, and lysine-12.
In the main promoters of silenced rRNA gene copies, histone H3 is methylated on lysine-9 (H3K9) by an unknown histone methyltransferase. H3K9 methylation is still observed when deacetylation is inhibited, therefore histone methylation does not depend on deacetylation. However histone deacetylation is required for DNA methylation. Significantly more dimethylation than trimethylation is observed.
Participants
Input
AdoMet [nucleoplasm]
Chromatin (H4K5ac, H4K8ac, H4K16ac) [nucleoplasm]
(Homo sapiens)
Output
AdoHcy [nucleoplasm]
CH3COO- [nucleoplasm]
Chromatin (H3K9me2) [nucleoplasm]
(Homo sapiens)
Participates
as an event of
NoRC negatively regulates rRNA expression (Homo sapiens)
Catalyst Activity
histone deacetylase activity of NoRC:pRNA:HDAC:DNMT [nucleoplasm]
Physical Entity
NoRC:pRNA:HDAC:DNMT [nucleoplasm]
(Homo sapiens)
Activity
histone deacetylase activity (GO:0004407)
Inferred From
NoRC:intergenic spacer:Hdac:Dnmt complex deacetylates histone H4 and dimethylates lysine-9 of histone H3 in main promoter of the rRNA gene (Mus musculus)
Authored
May, B (2009-06-19)
Reviewed
Shiao, YH (2014-02-18)
Created
May, B (2009-08-25)
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