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Proton-coupled monocarboxylate transport
Stable Identifier
R-HSA-433692
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Proton-coupled monocarboxylate transport (Homo sapiens)
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The SLC16A gene family encode proton-linked monocarboxylate transporters (MCT) which mediate the transport of monocarboxylates such as lactate and pyruvate. Monocarboxylates are a major energy source for all cells in the body so their transport in and out of cells is crucial for cellular function. To date, 14 SLC16A members have been identified through sequence homology. Of these 14 members, only seven isoforms have been functionally characterized and not all of these function as proton-coupled transporters. A number can transport diuretics, thyroid hormones and aromatic amino acids. The seven remaining SLC16A members are classed as orphan MCTs (Morris & Felmlee 2008, Merezhinskaya & Fishbein 2009).
In mammalian cells, MCTs (monocarboxylate transporters) require association with an ancillary protein to enable plasma membrane expression of the active transporter. Basigin (BSG, CD147) is the preferred binding partner for MCT1, MCT3 and MCT4, while MCT2 requires Embigin (EMB) (Wilson et al. 2005).
Literature References
PubMed ID
Title
Journal
Year
18523892
Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid
Morris, ME
,
Felmlee, MA
AAPS J
2008
19085840
Monocarboxylate transporters: past, present, and future
Fishbein, WN
,
Merezhinskaya, N
Histol Histopathol
2009
Participants
Events
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol
(Homo sapiens)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol
(Homo sapiens)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region
(Homo sapiens)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol
(Homo sapiens)
Participates
as an event of
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Orthologous Events
Proton-coupled monocarboxylate transport (Bos taurus)
Proton-coupled monocarboxylate transport (Caenorhabditis elegans)
Proton-coupled monocarboxylate transport (Canis familiaris)
Proton-coupled monocarboxylate transport (Danio rerio)
Proton-coupled monocarboxylate transport (Drosophila melanogaster)
Proton-coupled monocarboxylate transport (Gallus gallus)
Proton-coupled monocarboxylate transport (Mus musculus)
Proton-coupled monocarboxylate transport (Rattus norvegicus)
Proton-coupled monocarboxylate transport (Sus scrofa)
Proton-coupled monocarboxylate transport (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000570
Authored
Jassal, B (2009-08-25)
Reviewed
He, L (2009-11-12)
Matthews, L (2024-02-28)
Created
Jassal, B (2009-08-25)
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