SUMOylation of NR3C1 (GR) with SUMO1

Stable Identifier
R-HSA-4341025
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
SUMOylation of Glucocorticoid receptor with SUMO1
ReviewStatus
5/5
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NR3C1 (Glucocorticoid receptor, GR) is SUMOylated at lysine-277 and lysine-293 with SUMO1 (Tian et al. 2002, Impens et al. 2014). SUMOylation is enhanced when NR3C1 binds ligand (dexamethasone). SUMOylation reduces transcription activation by NR3C1.
Literature References
PubMed ID Title Journal Year
12144530 Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor

Palvimo, JJ, Jänne, OA, Tian, S, Poukka, H

Biochem. J. 2002
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Cossart, P, Radoshevich, L, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
Participants
Participates
Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [cytoplasm]

Orthologous Events
Authored
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