SUMOylation of RXRA with SUMO1

Stable Identifier
R-HSA-4341048
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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RXRA (Retinoid X receptor alpha) is SUMOylated at lysine-108 with SUMO1 (Choi et al. 2006). SUMOylation represses transcription activation by RXRA.
Literature References
PubMed ID Title Journal Year
16912044 Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1

Lee, MH, Chung, SS, Seol, JH, Lee, HW, Baek, SH, Choi, SJ, Bang, OS, Choi, HS, Chung, CH, Rho, EJ

J. Biol. Chem. 2006
Participants
Participates
Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [cytoplasm]

Orthologous Events
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