PIAS3 SUMOylates PGR with SUMO1

Stable Identifier
R-HSA-4341073
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PIAS3 SUMOylates PGR (Progesterone receptor, PR) at lysine-7, lysine-388, and lysine-531 with SUMO1 (Man et al. 2006, Daniel et al. 2007, Abdel-Hafiz et al. 2009). SUMOylation inhibits hormone-dependent transcription activation by PGR.
Literature References
PubMed ID Title Journal Year
17020914 PIAS3 induction of PRB sumoylation represses PRB transactivation by destabilizing its retention in the nucleus

Shen, BF, Li, HY, Zhang, PJ, He, K, Pan, X, Zhou, T, Liang, B, Li, AL, Yu, M, Man, JH, Zhao, J, Jin, BF, Gong, WL, Zhang, XM, Xia, Q

Nucleic Acids Res. 2006
19211567 Mechanisms underlying the control of progesterone receptor transcriptional activity by SUMOylation

Dudevoir, ML, Abdel-Hafiz, H, Horwitz, KB

J. Biol. Chem. 2009
17717077 Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells

Lange, CA, Faivre, EJ, Daniel, AR

Mol. Endocrinol. 2007
Participants
Participates
Catalyst Activity

SUMO transferase activity of PIAS3 [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
Cite Us!