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SORT1 [Golgi membrane]
Stable Identifier
R-HSA-434332
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
Sortilin, SORT_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
trans-Golgi Network Vesicle Budding (Homo sapiens)
Golgi Associated Vesicle Biogenesis (Homo sapiens)
Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Homo sapiens)
Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
SORT1 [Golgi membrane] (Homo sapiens)
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
SORT1 [Golgi membrane] (Homo sapiens)
trans-Golgi Network Coat Assembly (Homo sapiens)
Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
SORT1 [Golgi membrane] (Homo sapiens)
Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Homo sapiens)
Cargo:AP-1:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
SORT1 [Golgi membrane] (Homo sapiens)
trans-Golgi Network Vesicle Scission (Homo sapiens)
Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Homo sapiens)
Cargo:AP-1:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
SORT1 [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99523 SORT1
Gene Names
SORT1
Chain
signal peptide:1-33, propeptide:34-77, chain:78-831
Reference Genes
COSMIC (genes):SORT1 SORT1
dbSNP Gene:6272 SORT1
ENSEMBL:ENSG00000134243 SORT1
Participates
as a candidate of
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
Other forms of this molecule
SORT1 [cytoplasmic vesicle membrane]
Inferred To
VTH2 [Golgi membrane]
(Saccharomyces cerevisiae)
SORT1 [Golgi membrane]
(Bos taurus)
SORT1 [Golgi membrane]
(Canis familiaris)
SORT1 [Golgi membrane]
(Gallus gallus)
SORT1 [Golgi membrane]
(Saccharomyces cerevisiae)
SORT1 [Golgi membrane]
(Sus scrofa)
PEP1 [Golgi membrane]
(Saccharomyces cerevisiae)
Sort1 [Golgi membrane]
(Mus musculus)
Sort1 [Golgi membrane]
(Rattus norvegicus)
VTH1 [Golgi membrane]
(Saccharomyces cerevisiae)
Homologues of SORT1 [Golgi membrane]
(Saccharomyces cerevisiae)
sort1 [Golgi membrane]
(Dictyostelium discoideum)
sort1 [Golgi membrane]
(Xenopus tropicalis)
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01138 NGF
7
NGF [Golgi lumen]
(R-HSA-166515)
NGF(19-241) [extracellular region]
(R-HSA-187033)
NGF [cytosol]
(R-HSA-190059)
NGF(1-241) [endoplasmic reticulum lumen]
(R-HSA-187026)
NGF(19-241) [Golgi lumen]
(R-HSA-187036)
NGF(19-241) [endoplasmic reticulum lumen]
(R-HSA-187047)
NGF [extracellular region]
(R-HSA-167034)
0.676
5
UniProt:P11151
1
LPL [extracellular region]
(R-BTA-174605)
0.659
6
UniProt:P30990 NTS
3
NTS(151-160) [extracellular region]
(R-HSA-8940947)
NTS(161-163) [extracellular region]
(R-HSA-8940954)
NTS(151-163) [extracellular region]
(R-HSA-388915)
0.609
2
UniProt:P05231 IL6
3
IL6 [extracellular region]
(R-HSA-447100)
IL6 [endoplasmic reticulum lumen]
(R-HSA-8956764)
p-IL6 [endoplasmic reticulum lumen]
(R-HSA-8957044)
0.571
4
UniProt:P26441 CNTF
1
CNTF [extracellular region]
(R-HSA-5696441)
0.571
6
UniProt:P24941 CDK2
5
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
CDK2 [nucleoplasm]
(R-HSA-68365)
CDK2 [cytosol]
(R-HSA-157440)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
0.564
2
UniProt:P02787 TF
6
TF [endoplasmic reticulum lumen]
(R-HSA-8956763)
p-TF [endoplasmic reticulum lumen]
(R-HSA-8957001)
apoTF [endosome membrane]
(R-HSA-917974)
apoTF [extracellular region]
(R-HSA-350754)
TF [secretory granule lumen]
(R-HSA-350704)
apoTF [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869140)
0.556
3
UniProt:Q16288 NTRK3
6
p-5Y-NTRK3 [plasma membrane]
(R-HSA-9034718)
NTRK3 [plasma membrane]
(R-HSA-6798240)
NTRK3(496-641) [cytosol]
(R-HSA-9603542)
NTRK3(496-641) [mitochondrial outer membrane]
(R-HSA-9603557)
NTRK3(642-839) [cytosol]
(R-HSA-9603540)
NTRK3(32-495) [plasma membrane]
(R-HSA-9603541)
0.544
2
UniProt:Q9JLC4 Sorcs1
1
Sorcs1 [Golgi membrane]
(R-MMU-8931817)
0.544
2
UniProt:P42702 LIFR
1
LIFR [plasma membrane]
(R-HSA-5693181)
0.506
3
UniProt:P04629 NTRK1
4
p-5Y-NTRK1 [Golgi membrane]
(R-HSA-3008810)
NTRK1 [Golgi membrane]
(R-HSA-3008805)
NTRK1 [plasma membrane]
(R-HSA-3008784)
p-5Y-NTRK1 [plasma membrane]
(R-HSA-3009413)
0.463
3
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