Reactome | SORT1 [Golgi membrane]

SORT1 [Golgi membrane]

Stable Identifier

R-HSA-434332

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Sortilin, SORT_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q99523 SORT1

Gene Names

SORT1

Chain

signal peptide:1-33, propeptide:34-77, chain:78-831

Reference Genes

BioGPS Gene:6272 SORT1

COSMIC (genes):SORT1 SORT1

CTD Gene:6272 SORT1

dbSNP Gene:6272 SORT1

ENSEMBL:ENSG00000134243 SORT1

HGNC:11186 SORT1

KEGG:hsa:6272 SORT1

Monarch:6272 SORT1

NCBI Gene:6272 SORT1

OMIM:602458 SORT1

UCSC:Q99523 SORT1

Reference Transcript

Participates

as a candidate of

Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)

Other forms of this molecule

SORT1 [cytoplasmic vesicle membrane]

Inferred To

VTH2 [Golgi membrane] (Saccharomyces cerevisiae)

SORT1 [Golgi membrane] (Bos taurus)

SORT1 [Golgi membrane] (Canis familiaris)

SORT1 [Golgi membrane] (Gallus gallus)

SORT1 [Golgi membrane] (Saccharomyces cerevisiae)

SORT1 [Golgi membrane] (Sus scrofa)

PEP1 [Golgi membrane] (Saccharomyces cerevisiae)

Sort1 [Golgi membrane] (Mus musculus)

Sort1 [Golgi membrane] (Rattus norvegicus)

VTH1 [Golgi membrane] (Saccharomyces cerevisiae)

Homologues of SORT1 [Golgi membrane] (Saccharomyces cerevisiae)

sort1 [Golgi membrane] (Dictyostelium discoideum)

sort1 [Golgi membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_002950.3, NP_001192157.1

Guide to Pharmacology - Targets

3300

OpenTargets

ENSG00000134243

ENSEMBL

ENST00000256637, ENSG00000134243, ENSP00000438597, ENST00000538502, ENSP00000256637

ZINC - Substances

SORT_HUMAN

ZINC target

Q99523

PRO

Q99523

GlyGen

Q99523

PDB

5MRI, 5MRH, 6EHO, 6X3L, 3G2V, 6X4H, 4N7E, 6X48, 8T8R, 4MSL, 3F6K, 8T8S, 4PO7, 3G2U

ZINC - Investigational

SORT_HUMAN

HPA

ENSG00000134243-SORT1

GeneCards

SORT1

Pharos - Targets

Q99523

ZINC - Predictions - Purchasable

SORT_HUMAN

HMDB Protein

HMDBP10753

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01138 NGF	7	NGF [extracellular region] (R-HSA-167034) NGF(19-241) [endoplasmic reticulum lumen] (R-HSA-187047) NGF(19-241) [Golgi lumen] (R-HSA-187036) NGF(1-241) [endoplasmic reticulum lumen] (R-HSA-187026) NGF [cytosol] (R-HSA-190059) NGF(19-241) [extracellular region] (R-HSA-187033) NGF [Golgi lumen] (R-HSA-166515)	0.676	5
UniProt:P11151	1	LPL [extracellular region] (R-BTA-174605)	0.659	6
UniProt:P30990 NTS	3	NTS(151-160) [extracellular region] (R-HSA-8940947) NTS(161-163) [extracellular region] (R-HSA-8940954) NTS(151-163) [extracellular region] (R-HSA-388915)	0.609	2
UniProt:P26441 CNTF	1	CNTF [extracellular region] (R-HSA-5696441)	0.571	6
UniProt:P05231 IL6	3	IL6 [extracellular region] (R-HSA-447100) IL6 [endoplasmic reticulum lumen] (R-HSA-8956764) p-IL6 [endoplasmic reticulum lumen] (R-HSA-8957044)	0.571	4
UniProt:P24941 CDK2	5	p-T160-CDK2 [nucleoplasm] (R-HSA-187967) CDK2 [nucleoplasm] (R-HSA-68365) CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905)	0.564	2
UniProt:P02787 TF	6	apoTF [extracellular region] (R-HSA-350754) apoTF [endosome membrane] (R-HSA-917974) TF [endoplasmic reticulum lumen] (R-HSA-8956763) p-TF [endoplasmic reticulum lumen] (R-HSA-8957001) apoTF [clathrin-coated endocytic vesicle membrane] (R-HSA-8869140) TF [secretory granule lumen] (R-HSA-350704)	0.556	3
UniProt:Q9JLC4 Sorcs1	1	Sorcs1 [Golgi membrane] (R-MMU-8931817)	0.544	2
UniProt:Q16288 NTRK3	6	p-5Y-NTRK3 [plasma membrane] (R-HSA-9034718) NTRK3 [plasma membrane] (R-HSA-6798240) NTRK3(496-641) [cytosol] (R-HSA-9603542) NTRK3(496-641) [mitochondrial outer membrane] (R-HSA-9603557) NTRK3(642-839) [cytosol] (R-HSA-9603540) NTRK3(32-495) [plasma membrane] (R-HSA-9603541)	0.544	2
UniProt:P21453 S1PR1	1	S1PR1 [plasma membrane] (R-HSA-419340)	0.527	2
UniProt:P42702 LIFR	1	LIFR [plasma membrane] (R-HSA-5693181)	0.506	3
UniProt:P04629 NTRK1	4	p-5Y-NTRK1 [plasma membrane] (R-HSA-3009413) NTRK1 [plasma membrane] (R-HSA-3008784) NTRK1 [Golgi membrane] (R-HSA-3008805) p-5Y-NTRK1 [Golgi membrane] (R-HSA-3008810)	0.463	3

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