Reactome | SNX2 [Golgi membrane]

SNX2 [Golgi membrane]

Stable Identifier

R-HSA-434333

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Sorting nexin-2, SNX2_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - trans-Golgi Network Vesicle Budding (Homo sapiens)
    - Golgi Associated Vesicle Biogenesis (Homo sapiens)
      - Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Homo sapiens)
        
        Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
        
        Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
        
        SNX2 [Golgi membrane] (Homo sapiens)
        
        Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
        
        SNX2 [Golgi membrane] (Homo sapiens)
      - trans-Golgi Network Coat Assembly (Homo sapiens)
        
        Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
        
        Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
        
        SNX2 [Golgi membrane] (Homo sapiens)
        
        Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Homo sapiens)
        
        Cargo:AP-1:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
        
        Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
        
        SNX2 [Golgi membrane] (Homo sapiens)
      - trans-Golgi Network Vesicle Scission (Homo sapiens)
        
        Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Homo sapiens)
        
        Cargo:AP-1:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
        
        Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
        
        SNX2 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60749 SNX2

Gene Names

SNX2, TRG9

Chain

chain:1-519

Reference Genes

BioGPS Gene:6643 SNX2

COSMIC (genes):SNX2 SNX2

CTD Gene:6643 SNX2

dbSNP Gene:6643 SNX2

ENSEMBL:ENSG00000205302 SNX2

ENSEMBL:ENSG00000205302.7 SNX2

HGNC:11173 SNX2

KEGG Gene (Homo sapiens):6643 SNX2

Monarch:6643 SNX2

NCBI Gene:6643 SNX2

OMIM:605929 SNX2

UCSC:O60749 SNX2

Reference Transcript

Other Identifiers

11742742_a_at

16988510

202113_PM_s_at

202113_s_at

202114_PM_at

202114_at

232049_PM_at

232049_at

2826296

2826297

2826298

2826299

2826300

2826301

2826304

2826305

2826306

2826307

2826310

2826314

2826315

2826316

2826317

2826319

2826321

2826323

2826328

2826329

2826330

2826331

2826332

2826333

2826334

2826335

2826336

2826338

2826340

41462_at

64317_f_at

64318_f_at

6643

73892_at

8107613

81904_at

91915_at

A_14_P135596

A_23_P7697

A_32_P542318

GE522840

GE81235

GO:0005154

GO:0005158

GO:0005515

GO:0005737

GO:0005764

GO:0005768

GO:0005773

GO:0005829

GO:0006886

GO:0008289

GO:0010008

GO:0015031

GO:0016020

GO:0016192

GO:0030027

GO:0030904

GO:0030905

GO:0031410

GO:0031901

GO:0032991

GO:0034498

GO:0035091

GO:0042147

GO:0042802

GO:0042803

GO:0042995

GO:0043226

GO:0045296

GO:0046982

GO:0048856

GO:0051641

GO:0072673

GO:1990459

GO:1990460

HMNXSV003039214

Hs.125352.0.S1_3p_at

ILMN_1691575

PH_hs_0001091

PH_hs_0007081

TC05000576.hg

TC05002596.hg

g2827433_3p_a_at

g4507140_3p_at

Participates

as a candidate of

Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)

Other forms of this molecule

SNX2 [cytoplasmic vesicle membrane]

Inferred To

Snx1 [Golgi membrane] (Drosophila melanogaster)

Snx2 [Golgi membrane] (Rattus norvegicus)

snx-1 [Golgi membrane] (Caenorhabditis elegans)

vps5 [Golgi membrane] (Dictyostelium discoideum)

SNX2 [Golgi membrane] (Bos taurus)

SNX2 [Golgi membrane] (Canis familiaris)

SNX2 [Golgi membrane] (Danio rerio)

SNX2 [Golgi membrane] (Gallus gallus)

SNX2 [Golgi membrane] (Mus musculus)

SNX2 [Golgi membrane] (Saccharomyces cerevisiae)

SNX2 [Golgi membrane] (Sus scrofa)

Cross References

RefSeq

NP_001265128.1, NP_003091.2

OpenTargets

ENSG00000205302

GeneCards

O60749

HPA

ENSG00000205302-SNX2

Ensembl

ENSG00000205302, ENSP00000368831, ENST00000379516, ENSP00000421663, ENST00000514949

PRO

O60749

Pharos - Targets

O60749

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:O60664 PLIN3	7	p-PLIN3 [lysosomal lumen] (R-HSA-9639396) p-PLIN3 [cytosol] (R-HSA-9613664) p-PLIN3 [lipid droplet] (R-HSA-9613539) PLIN3 [lipid droplet] (R-HSA-9613337) p-PLIN3 [late endosome lumen] (R-HSA-9639393) PLIN3 [cytosol] (R-HSA-6814628) PLIN3 [transport vesicle] (R-HSA-6813900)	0.556	3
UniProt:Q9H2K0 MTIF3	1	MTIF3 [mitochondrial matrix] (R-HSA-5368284)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6