ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A

Stable Identifier
R-HSA-434382
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
a long-chain fatty acid + ATP + CoA => a long-chain fatty acyl-CoA + AMP + diphosphate
ReviewStatus
5/5
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ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A
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ACSL3 and ACSL4 found on the mitochondria of pancreatic beta cells ligate coenzyme A (Co-A) to fatty acids such as palmitate (Ansari et al. 2017) prior to transport into mitochondria by the carnitine system and beta oxidation in the mitochondrial matrix yielding ATP.
Literature References
PubMed ID Title Journal Year
28193492 Characterization of Acyl-CoA synthetase isoforms in pancreatic beta cells: Gene silencing shows participation of ACSL3 and ACSL4 in insulin secretion

Ansari, IH, Longacre, MJ, Stoker, SW, Kendrick, MA, O'Neill, LM, Zitur, LJ, Fernandez, LA, Ntambi, JM, MacDonald, MJ

Arch. Biochem. Biophys. 2017
Participants
Input
Output
Participates
as an event of
Catalyst Activity

palmitoyl-CoA ligase activity of ACSL3,4 [mitochondrial outer membrane]

Physical Entity
ACSL3,4 [mitochondrial outer membrane] (Homo sapiens)
Activity
palmitoyl-CoA ligase activity (GO:0090433)
Orthologous Events
ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A (Bos taurus)
ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A (Caenorhabditis elegans)
ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A (Canis familiaris)
ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A (Danio rerio)
ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A (Drosophila melanogaster)
ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A (Gallus gallus)
ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A (Mus musculus)
ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A (Rattus norvegicus)
ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A (Saccharomyces cerevisiae)
ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A (Schizosaccharomyces pombe)
ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A (Sus scrofa)
ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A (Xenopus tropicalis)
Cross References
RHEA
Authored
May, B  (2009-08-28)
Reviewed
D'Eustachio, P  (2018-12-22)
Hill, DP  (2025-06-02)
Created
May, B  (2009-08-28)
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