Reactome | BCHE [extracellular region]

BCHE [extracellular region]

Stable Identifier

R-HSA-434469

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Butyrylcholinesterase, Cholinesterase, CHLE_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O60832 DKC1

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External Reference Information

External Reference

UniProt:P06276 BCHE

Gene Names

BCHE, CHE1

Chain

signal peptide:1-28, chain:29-602

Reference Genes

BioGPS Gene:590 BCHE

COSMIC (genes):BCHE BCHE

CTD Gene:590 BCHE

dbSNP Gene:590 BCHE

ENSEMBL:ENSG00000114200 BCHE

ENSEMBL_homo_sapiens_GENE:ENSG00000114200.10 BCHE

HGNC:983 BCHE

KEGG Gene (Homo sapiens):590 BCHE

Monarch:590 BCHE

NCBI Gene:590 BCHE

OMIM:177400 BCHE

UCSC:P06276 BCHE

Reference Transcript

RefSeq:NM_000055.3 BCHE

Other Identifiers

11746149_x_at

11751833_a_at

16961172

205433_PM_at

205433_at

2703904

2703905

2703906

2703907

2703912

2703913

2703919

2703920

2703922

37841_at

590

8091867

A_23_P212050

GE58204

GO:0001540

GO:0003824

GO:0003990

GO:0004104

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005635

GO:0005641

GO:0005783

GO:0005788

GO:0005886

GO:0006581

GO:0006805

GO:0007584

GO:0007612

GO:0008285

GO:0009410

GO:0014016

GO:0016486

GO:0016787

GO:0016788

GO:0019695

GO:0019899

GO:0023052

GO:0030154

GO:0033265

GO:0042802

GO:0043226

GO:0043279

GO:0048856

GO:0050783

GO:0050805

GO:0050877

GO:0051384

GO:0051593

GO:0051604

GO:0052689

GO:0072562

HMNXSV003008228

ILMN_1685641

ILMN_2176592

M16474_s_at

PH_hs_0025160

TC03001970.hg

g4557350_3p_at

Participates

as a member of

Butyrylcholinesterase [extracellular region] (Homo sapiens)

Other forms of this molecule

BCHE [plasma membrane]

Inferred To

Ace [extracellular region] (Drosophila melanogaster)

BCHE [extracellular region] (Bos taurus)

BCHE [extracellular region] (Canis familiaris)

BCHE [extracellular region] (Gallus gallus)

BCHE [extracellular region] (Mus musculus)

ace-1 [extracellular region] (Caenorhabditis elegans)

Bche [extracellular region] (Rattus norvegicus)

bchel [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_000046.1

ZINC - World Drugs

CHLE_HUMAN

Guide to Pharmacology - Targets

2471

OpenTargets

ENSG00000114200

ZINC - FDA approved

CHLE_HUMAN

ZINC - Substances

CHLE_HUMAN

ZINC - Biogenic

CHLE_HUMAN

ZINC target

P06276

PRO

P06276

PDB

1XLW, 8AI7, 3DKK, 8AM2, 6EQP, 6EQQ, 6ESJ, 5DYY, 1XLV, 6XTA, 2WIG, 6I0B, 7Q1M, 5LKR, 6T9P, 6ESY, 7Q1N, 8AM1, 7Q1O, 6ZWI, 2PM8, 3DJY, 2XQK, 6T9S, 8CGO, 6QAD, 2J4C, 4AQD, 5DYW, 7AWG, 4TPK, 4BDS, 4B0P, 6I2T, 7QBQ, 4B0O, 6EMI, 7QHE, 7AIY, 6R6W, 5DYT, 7AWH, 7AWI, 6QAB, 2XMG, 6SAM, 2WID, 6EYF, 7Q1P, 6QAA, 1P0P, 2WIF, 2Y1K, 2XQF, 1P0Q, 6F7Q, 7QHD, 5NN0, 6QAC, 5K5E, 7BGC, 2XQJ, 2WIJ, 2XQG, 6EZ2, 2XQI, 7QBR, 3O9M, 2WIK, 2WIL, 6QAE, 2XMB, 6I0C, 4XII, 6R6V, 2WSL, 7BO4, 7AMZ, 6RUA, 2XMC, 2XMD, 6EP4, 4BBZ, 1XLU, 1P0I, 4AXB, 7ZPB, 1P0M, 7BO3

ZINC - Investigational

CHLE_HUMAN

ZINC - Metabolites

CHLE_HUMAN

IntEnz

3.1.1.8

HPA

ENSG00000114200-BCHE

GeneCards

P06276

Ensembl

ENST00000264381, ENSG00000114200, ENSP00000264381

Pharos - Targets

P06276

Orphanet

15359

ZINC - Predictions - Purchasable

CHLE_HUMAN

HMDB Protein

HMDBP00525

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06276 BCHE	2	BCHE [extracellular region] (R-HSA-434469) BCHE [plasma membrane] (R-HSA-3640835)	0.842	8
UniProt:P02814 SMR3B			0.564	2
UniProt:P67812 SEC11A	1	SEC11A [endoplasmic reticulum membrane] (R-HSA-265024)	0.556	3
UniProt:O75400-2 PRPF40A			0.556	3
UniProt:P62826 RAN	2	RAN [nucleoplasm] (R-HSA-165528) RAN [cytosol] (R-HSA-165540)	0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:P46379-2 BAG6			0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:O75190-2 DNAJB6			0.556	3
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	3
UniProt:P55212 CASP6	5	CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.556	3
UniProt:Q9NPE3 NOP10	1	NOP10 [nucleoplasm] (R-HSA-6790665)	0.527	2
UniProt:O75356 ENTPD5	1	ENTPD5 [extracellular region] (R-HSA-8851371)	0.527	2
UniProt:Q96HR8 NAF1			0.527	2
UniProt:O95968 SG1D1			0.527	2
UniProt:Q08397 LOXL1	3	LOXL1(26-94) [extracellular region] (R-HSA-2022105) LOXL1(26-574) [extracellular region] (R-HSA-2022093) LOXL1 [extracellular region] (R-HSA-2022107)	0.527	2
UniProt:Q14766 LTBP1	3	p-LTBP1 [endoplasmic reticulum lumen] (R-HSA-8957050) LTBP1 [endoplasmic reticulum lumen] (R-HSA-8956770) LTBP1 [extracellular region] (R-HSA-2161391)	0.527	2
UniProt:Q9NZB2 F120A			0.527	2
UniProt:Q6XE38 SG1D4			0.527	2
UniProt:Q9NSV4 DIAPH3	1	DIAPH3 [cytosol] (R-HSA-5666125)	0.527	2
UniProt:Q08043 ACTN3	1	ACTN3 [cytosol] (R-HSA-390565)	0.527	2
UniProt:Q9UK22 FBXO2	1	FBXO2 [cytosol] (R-HSA-976044)	0.527	2
UniProt:Q12797 ASPH	2	ASPH [endoplasmic reticulum lumen] (R-HSA-9631383) ASPH [endoplasmic reticulum membrane] (R-HSA-5490331)	0.527	2
UniProt:O00401 WASL	4	N-WASP [cytosol] (R-HSA-201873) p-Y256-WASL [cytosol] (R-HSA-2197672) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.527	2
UniProt:P59665 DEFA1	9	DEFA1(65-94) [azurophil granule lumen] (R-HSA-1470053) omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region] (R-HSA-1972397) DEFA1(65-94) [extracellular region] (R-HSA-1462022) DEFA1(66-94) [azurophil granule lumen] (R-HSA-1470038) DEFA1(66-94) [extracellular region] (R-HSA-1461998) DEFA1(20-65) [Golgi lumen] (R-HSA-8864970) DEFA1(66-94) [Golgi lumen] (R-HSA-975663) DEFA1(20-94) [Golgi lumen] (R-HSA-1467282) DEFA1(1-94) [Golgi lumen] (R-HSA-1467215)	0.527	2
UniProt:O60832 DKC1	1	DKC1 [nucleoplasm] (R-HSA-163102)	0.527	2

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