Syk/Lck phosphorylate LAT

Stable Identifier
R-HSA-434836
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Syk/Lck phosphorylate LAT
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Activated Syk (or possibly the related kinase Lck) phosphorylates two key tyrosine residues of LAT.
Literature References
PubMed ID Title Journal Year
16938345 Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes

Jiang, Y, Cheng, H

Leuk Res 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of p-Y348-SYK/LCK [cytosol]

Physical Entity
p-Y348-SYK/LCK [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Syk/Lck phosphorylate LAT (Bos taurus)
Syk/Lck phosphorylate LAT (Canis familiaris)
Syk/Lck phosphorylate LAT (Mus musculus)
Syk/Lck phosphorylate LAT (Rattus norvegicus)
Syk/Lck phosphorylate LAT (Sus scrofa)
Authored
Akkerman, JW  (2009-09-04)
Reviewed
Harper, MT  (2009-11-02)
Poole, AW  (2009-11-02)
Jones, ML  (2009-11-02)
Created
Jupe, S  (2009-09-03)
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