NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages

Stable Identifier
R-HSA-435171
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Natural resistance-associated macrophage proteins (NRAMPs) regulate macrophage activation for antimicrobial activity against intracellular pathogens. They do this by mediating bivalent metal ion transport across macrophage membranes and the subsequent use of these ions in the Fenton/and or Haber–Weiss reactions of free radical formation.
The human gene SLC11A1 encodes NRAMP1 (Kishi F, 2004; Kishi F and Nobumoto M, 1995) which can utilize the protonmotive force to mediate divalent iron (Fe2+), zinc (Zn2+) and manganese (Mn2+) influx to or efflux from phagosomes.

Literature References
PubMed ID Title Journal Year
7980580 Isolation and characterization of human Nramp cDNA

Kishi, F

Biochem Biophys Res Commun 1994
8537108 Identification of natural resistance-associated macrophage protein in peripheral blood lymphocytes

Kishi, F, Nobumoto, M

Immunol Lett 1995
Participants
Participates
Catalyst Activity

metal ion:proton antiporter activity of SLC11A1 [late endosome membrane]

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