Reactome | SLC30A2 [endosome membrane]

SLC30A2 [endosome membrane]

Stable Identifier

R-HSA-435363

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

ZnT2, Zinc transporter 2, ZNT2_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P16278 GLB1

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Transport of small molecules (Homo sapiens)

- SLC-mediated transmembrane transport (Homo sapiens)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
    - Metal ion SLC transporters (Homo sapiens)
      - Zinc transporters (Homo sapiens)
        
        Zinc efflux and compartmentalization by the SLC30 family (Homo sapiens)
        
        ZnT2 facilitates zinc vesicular sequestration (Homo sapiens)
        
        SLC30A2 [endosome membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BRI3 SLC30A2

Gene Names

SLC30A2, ZNT2

Chain

chain:1-372

Reference Genes

BioGPS Gene:7780 SLC30A2

COSMIC (genes):SLC30A2 SLC30A2

CTD Gene:7780 SLC30A2

dbSNP Gene:7780 SLC30A2

ENSEMBL:ENSG00000158014 SLC30A2

ENSEMBL_homo_sapiens_GENE:ENSG00000158014.15 SLC30A2

HGNC:11013 SLC30A2

KEGG Gene (Homo sapiens):7780 SLC30A2

Monarch:7780 SLC30A2

NCBI Gene:7780 SLC30A2

OMIM:609617 SLC30A2

UCSC:Q9BRI3 SLC30A2

Reference Transcript

Other Identifiers

11741578_a_at

11741579_a_at

16683758

224485_PM_s_at

224485_s_at

230084_PM_at

230084_at

2402518

2402519

2402520

2402521

2402522

2402523

2402524

2402525

2402526

2402527

2402528

2402529

2402530

2402531

2402533

7780

7913896

90456_at

A_23_P319083

A_24_P156748

GE62950

GO:0005215

GO:0005385

GO:0005515

GO:0005737

GO:0005739

GO:0005743

GO:0005764

GO:0005765

GO:0005768

GO:0005770

GO:0005773

GO:0005886

GO:0006811

GO:0006812

GO:0006829

GO:0006882

GO:0008324

GO:0010008

GO:0010043

GO:0015297

GO:0016020

GO:0030658

GO:0031410

GO:0042589

GO:0042802

GO:0043226

GO:0043231

GO:0046872

GO:0055065

GO:0055085

GO:0062111

GO:0071577

GO:0099503

GO:0140826

GO:0140882

GO:0140914

GO:0140915

GO:0140916

GO:0140917

HMNXSV003045001

Hs.143545.0.S1_3p_at

ILMN_1785549

ILMN_2415421

PH_hs_0031798

TC01002385.hg

g13623300_3p_s_at

Other forms of this molecule

SLC30A2 [synaptic vesicle membrane]

Cross References

RefSeq

NP_115902.1, NP_001004434.1

Guide to Pharmacology - Targets

1122

OpenTargets

ENSG00000158014

HPA

ENSG00000158014-SLC30A2

GeneCards

Q9BRI3

Ensembl

ENSP00000363396, ENSG00000158014, ENST00000374278, ENST00000374276, ENSP00000363394

PRO

Q9BRI3

Pharos - Targets

Q9BRI3

HMDB Protein

HMDBP12037

Interactors (74)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N6L0 KASH5			0.805	9
UniProt:P15151 PVR	1	PVR [plasma membrane] (R-HSA-420600)	0.781	11
UniProt:Q9NP84 TNFRSF12A	1	TNFRSF12A [plasma membrane] (R-HSA-5675666)	0.781	9
UniProt:P13236 CCL4	1	CCL4(24-92) [extracellular region] (R-HSA-443976)	0.781	8
UniProt:Q08AM2 Q08AM2			0.718	8
UniProt:Q99726 SLC30A3	1	SLC30A3 [synaptic vesicle membrane] (R-HSA-437087)	0.674	7
UniProt:Q5J8X5 M4A13			0.601	6
UniProt:Q6FG55 Q6FG55			0.556	3
UniProt:Q8N3T1 GALNT15	1	GALNT15 [Golgi membrane] (R-HSA-913705)	0.556	5
UniProt:P14151-2 P141512			0.556	3
UniProt:P11912 CD79A	2	p-Y188,Y199-CD79A [plasma membrane] (R-HSA-983539) CD79A [plasma membrane] (R-HSA-197154)	0.556	3
UniProt:Q9H2L4 TMM60			0.556	5
UniProt:Q14802-3 FXYD3			0.556	3
UniProt:Q9NYW4 TAS2R5	1	TAS2R5 [plasma membrane] (R-HSA-3299614)	0.556	3
UniProt:Q8TBP5 F174A			0.556	3
UniProt:Q96IW7 SEC22A	3	SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111) SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562) SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560)	0.556	3
UniProt:Q13651 IL10RA	3	p-Y446-IL10RA [plasma membrane] (R-HSA-6784810) p-Y496-IL10RA [plasma membrane] (R-HSA-6784793) IL10RA [plasma membrane] (R-HSA-449841)	0.556	3
UniProt:Q9NZD1 GPC5D			0.556	3
UniProt:A5PKU2 A5PKU2			0.556	3
UniProt:P36382 GJA5	1	GJA5 [endoplasmic reticulum membrane] (R-HSA-190648)	0.556	3
UniProt:Q9H0Q3 FXYD6	1	FXYD6 [plasma membrane] (R-HSA-2752104)	0.556	3
IntAct:EBI-23184686 CCSB ORF ID			0.556	3
UniProt:P16278 GLB1	8	GLB1 W509C [lysosomal lumen] (R-HSA-2262732) GLB1 Y83C [lysosomal lumen] (R-HSA-2262735) GLB1 R482C [lysosomal lumen] (R-HSA-2262739) GLB1 W273L [lysosomal lumen] (R-HSA-2262738) GLB1 [azurophil granule lumen] (R-HSA-6799124) GLB1 [lysosomal lumen] (R-HSA-1605623) GLB1 [ficolin-1-rich granule lumen] (R-HSA-6800968) GLB1 [extracellular region] (R-HSA-6806213)	0.556	3
UniProt:O95377 GJB5	1	GJB5 [endoplasmic reticulum membrane] (R-HSA-190643)	0.556	3
UniProt:Q4KMG9 TM52B			0.556	3
UniProt:P29033 GJB2	3	GJB2 [plasma membrane] (R-HSA-53211) GJB2 [endoplasmic reticulum membrane] (R-HSA-1629779) GJB2 [endoplasmic reticulum-Golgi intermediate compartment] (R-HSA-190614)	0.556	3
UniProt:Q04756 HGFAC	2	HGFAC(408-655) [cytosol] (R-HSA-6800283) HGFAC(373-407) [cytosol] (R-HSA-1641473)	0.556	3
UniProt:E9PK97 E9PK97			0.556	3
UniProt:Q9NP94 SLC39A2	1	SLC39A2 [plasma membrane] (R-HSA-442395)	0.556	3
UniProt:P34910-2 P349102			0.556	3
UniProt:Q9UHI5 SLC7A8	1	SLC7A8 [plasma membrane] (R-HSA-352156)	0.556	3
UniProt:P25942 CD40			0.556	3
UniProt:Q9BZ11-2 ADAM33			0.556	3
UniProt:A6NKB5-5 A6NKB55			0.556	3
UniProt:A0A0S2Z5R8 A0A0S2Z5R8			0.556	3
UniProt:O43889-2 CREB3			0.556	3
UniProt:O14569 C56D2			0.556	3
UniProt:Q6UWT4 CE046			0.556	5
UniProt:Q9Y375 NDUFAF1	1	NDUFAF1 [mitochondrial inner membrane] (R-HSA-5689050)	0.556	3
UniProt:Q59EV6 Q59EV6			0.556	3
UniProt:Q8IXM6 NRM			0.556	3
UniProt:Q8NHW4 CCL4L1	1	CCL4L1 [extracellular region] (R-HSA-8865389)	0.556	3
UniProt:Q9HD20-3 ATP13A1			0.556	3
UniProt:O00559 EBAG9	1	EBAG9 [Golgi membrane] (R-HSA-9018507)	0.556	3
UniProt:P41181 AQP2	3	AQP2 [transport vesicle membrane] (R-HSA-432215) p-S256-AQP2 [transport vesicle membrane] (R-HSA-432222) p-S256-AQP2 [plasma membrane] (R-HSA-432231)	0.556	3
UniProt:Q9Y624 F11R	2	F11R [cell junction] (R-HSA-2134498) F11R [plasma membrane] (R-HSA-197845)	0.556	3
UniProt:Q6UX40 TM107			0.556	3
UniProt:P54852 EMP3			0.556	3
UniProt:Q8WWF3 SSMM1			0.556	3
UniProt:P35372-10 OPRM1			0.556	3
UniProt:Q9Y5Y7 LYVE1	1	LYVE1 [plasma membrane] (R-HSA-2160921)	0.556	3
UniProt:O15529 GPR42			0.556	3
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.556	3
UniProt:Q6ZVE7 GOT1A			0.556	3
UniProt:Q96CE8 T4S18			0.556	3
UniProt:Q6IBD0 Q6IBD0			0.556	3
UniProt:O95870 ABHGA			0.556	3
UniProt:Q8TBJ4 PLPPR1	1	LPPR1 [plasma membrane] (R-HSA-6797625)	0.556	3
UniProt:Q12999 TSN31			0.556	3
UniProt:Q7Z7G2 CPLX4			0.556	3
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.556	3
UniProt:O15552 FFAR2	1	FFAR2 [plasma membrane] (R-HSA-443944)	0.556	3
UniProt:P14324 FDPS	1	FDPS [cytosol] (R-HSA-981566)	0.556	3
UniProt:Q8N6U8 GPR161	2	GPR161 [endocytic vesicle membrane] (R-HSA-5635021) GPR161 [ciliary membrane] (R-HSA-5610373)	0.556	3
UniProt:P54219-3 P542193			0.556	3
UniProt:Q8N2M4 TM86A			0.556	3
UniProt:Q9NVC3 S38A7			0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:Q9BWQ6 YIPF2			0.556	3
UniProt:O15554 KCNN4	1	KCNN4 [plasma membrane] (R-HSA-977543)	0.556	3
UniProt:P01374 LTA	1	LTA [plasma membrane] (R-HSA-5667153)	0.556	5
UniProt:Q6XR72 SLC30A10	1	SLC30A10 [plasma membrane] (R-HSA-437102)	0.537	3
UniProt:Q99376	5	Tfrc [clathrin-coated endocytic vesicle membrane] (R-RNO-8869124) Tfrc [Golgi membrane] (R-RNO-434330) Tfrc [cytoplasmic vesicle membrane] (R-RNO-434196) Tfrc [endosome membrane] (R-RNO-8961829) Tfrc [plasma membrane] (R-RNO-917983)	0.499	3
UniProt:Q8TC26 TM163			0.463	3

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