ZnT5 transports zinc into secretory granules in pancreatic beta cells

Stable Identifier
R-HSA-437085
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The human gene SLC30A5 encodes the zinc transporter ZnT5. This protein is widely expressed but is most abundant in pancreatic beta cells (Kambe T et al, 2002). In these cells, ZnT5 mediates the transport of zinc into secretory granules that contain insulin.
Literature References
PubMed ID Title Journal Year
11904301 Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells

Nagao, M, Mori, K, Sasaki, R, Yamaguchi-Iwai, Y, Kambe, T, Amano, T, Hirose, J, Sugiura, N, Iwanaga, T, Narita, H

J Biol Chem 2002
Participants
Participates
Catalyst Activity

zinc ion transmembrane transporter activity of SLC30A5 [secretory granule membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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