PDPK1 activates PRKCZ

Stable Identifier
R-HSA-437195
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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PDPK1 activates PRKCZ
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3-phosphoinositide dependent protein kinase-1 (Pdpk1, also known as Pdk1 and PKB kinase because of its activity at Protein kinase B) phosphorylates T410 of protein kinase C zeta type (Prkcz, also known as PKC zeta), leading to activation. The motif surrounding T410 is highly conserved in other PKC family members suggesting that Pdpk1 might activate other PKCs.
Literature References
PubMed ID Title Journal Year
9768361 Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

Lee, MH, Chen, CS, Chou, MM, Johnson, J, Toker, A, Graham, LK, Hou, W, Schaffhausen, BS, Newton, AC

Curr Biol 1998
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Catalyst Activity

3-phosphoinositide-dependent protein kinase activity of PDPK1:PIP3:PRKCZ [plasma membrane]

Physical Entity
PDPK1:PIP3:PRKCZ [plasma membrane] (Homo sapiens)
Activity
3-phosphoinositide-dependent protein kinase activity (GO:0004676)
Inferred From
PDK1 activates PKC zeta (Rattus norvegicus)
Authored
Akkerman, JW  (2009-09-04)
Reviewed
Harper, MT  (2009-11-02)
Poole, AW  (2009-11-02)
Jones, ML  (2009-11-02)
Created
Jupe, S  (2009-09-11)
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