Membrane depolarization upon activation of Ca impermeable AMPA receptors

Stable Identifier
R-HSA-438037
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Membrane depolarization upon activation of Ca impermeable AMPA receptors
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Membrane depolarization occurs due to glutamate dependent activation of Ca-impermeable AMPA receptors, which permits the influx of Na+ ions. The depolarization triggers the removal of Mg2+ from the NMDA receptor pore to facilitate its activation. Therefore, activation of AMPA receptors by glutamate precedes activation of NMDA receptors.

Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

excitatory extracellular ligand-gated ion channel activity of Ca impermeable AMPA receptor ligand complex [plasma membrane]

Physical Entity
Ca impermeable AMPA receptor ligand complex [plasma membrane] (Homo sapiens)
Activity
excitatory extracellular ligand-gated ion channel activity (GO:0005231)
This event is regulated
Positively by
Regulator
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
Orthologous Events
Membrane depolarization upon activation of Ca impermeable AMPA receptors (Bos taurus)
Membrane depolarization upon activation of Ca impermeable AMPA receptors (Caenorhabditis elegans)
Membrane depolarization upon activation of Ca impermeable AMPA receptors (Canis familiaris)
Membrane depolarization upon activation of Ca impermeable AMPA receptors (Danio rerio)
Membrane depolarization upon activation of Ca impermeable AMPA receptors (Drosophila melanogaster)
Membrane depolarization upon activation of Ca impermeable AMPA receptors (Gallus gallus)
Membrane depolarization upon activation of Ca impermeable AMPA receptors (Mus musculus)
Membrane depolarization upon activation of Ca impermeable AMPA receptors (Rattus norvegicus)
Membrane depolarization upon activation of Ca impermeable AMPA receptors (Sus scrofa)
Membrane depolarization upon activation of Ca impermeable AMPA receptors (Xenopus tropicalis)
Cross References
Rhea
Authored
Mahajan, SS  (2009-09-29)
Reviewed
Tukey, D  (2009-11-18)
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Created
Mahajan, SS  (2009-09-23)
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