Membrane depolarization upon activation of Ca impermeable AMPA receptors

Stable Identifier
R-HSA-438037
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Membrane depolarization occurs due to glutamate dependent activation of Ca-impermeable AMPA receptors, which permits the influx of Na+ ions. The depolarization triggers the removal of Mg2+ from the NMDA receptor pore to facilitate its activation. Therefore, activation of AMPA receptors by glutamate precedes activation of NMDA receptors.
Literature References
Participants
Output
Participates
Catalyst Activity

excitatory extracellular ligand-gated ion channel activity of Ca impermeable AMPA receptor ligand complex [plasma membrane]

This event is regulated
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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