Reactome | Activation of NLK

Activation of NLK

Stable Identifier

R-HSA-4411402

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NLK is activated in response to WNT5A in a CAMK2- and MAP3K7- dependent manner (Ishitani et al, 1999; Ishitani et al, 2003a,b). Homodimerization is required for NLK autophosphorylation at T298 and subsequent nuclear localization; mutation of C437 abolishes dimerization, kinase activity and nuclear translocation (Ishitani et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
12556497	Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling Ishitani, T, Matsumoto, K, Ninomiya-Tsuji, J	Mol. Cell. Biol.	2003
21118996	Homodimerization of Nemo-like kinase is essential for activation and nuclear localization Ishitani, T, Inaba, K, Matsumoto, K, Ishitani, S	Mol. Biol. Cell	2011
10391247	The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF Shibuya, H, Barker, N, Clevers, HC, Bowerman, B, Ishitani, T, Waterman, M, Matsumoto, K, Meneghini, M, Ninomiya-Tsuji, J, Nagai, S, Nishita, M	Nature	1999
12482967	The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling Shibuya, H, Ishitani, T, Hyodo-Miura, J, Waterman, M, Matsumoto, K, Yasuda, J, Ninomiya-Tsuji, J, Ueno, N, Moon, RT, Kishida, S	Mol. Cell. Biol.	2003