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CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
Stable Identifier
R-HSA-4416737
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
beta-catenin:destruction complex
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
Beta-catenin is released from the destruction complex (Homo sapiens)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex (Homo sapiens)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
Participants
components
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
(Homo sapiens)
CTNNB1 [cytosol]
(Homo sapiens)
Participates
as an output of
PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex (Homo sapiens)
as an input of
Beta-catenin is released from the destruction complex (Homo sapiens)
Inferred To
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
(Bos taurus)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
(Caenorhabditis elegans)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
(Canis familiaris)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
(Drosophila melanogaster)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
(Gallus gallus)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
(Mus musculus)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
(Rattus norvegicus)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
(Sus scrofa)
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