Reactome | Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT

Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT

Stable Identifier

R-HSA-4420052

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

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Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT

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IP3 promotes the release of intracellular calcium after initiation of WNT signaling. As a downstream consequence of WNT ligand binding, cytosolic cGMP levels decrease, reducing the activity of PKG and relieving its repression of the IP3 receptor. Subsequent binding of IP3 to the receptor allows efflux of the intracellular calcium from the endoplasmic reticulum (Ahumada et al, 2002; Ma and Yang, 2006; reviewed in Hoffman, 2005).

Literature References

PubMed ID	Title	Journal	Year
15545263	The biology of cyclic GMP-dependent protein kinases Hofmann, F	J Biol Chem	2005
12471263	Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP Wang, HY, Liu, X, Slusarski, DC, Malbon, CC, Ahumada, A, Moon, RT	Science	2002
16920709	Suppression of cyclic GMP-dependent protein kinase is essential to the Wnt/cGMP/Ca2+ pathway Wang, HY, Ma, L	J. Biol. Chem.	2006