Reactome | SH2D2A [cytosol]

SH2D2A [cytosol]

Stable Identifier

R-HSA-4420125

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TSAD, T-cell specific adapter molecule, VRAP, SH2 domain-containing protein 2A, VEGFR associated protein

Locations in the PathwayBrowser for interactor UniProt:P11277 SPTB

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External Reference Information

External Reference

UniProt:Q9NP31 SH2D2A

Gene Names

SH2D2A, SCAP, TSAD, VRAP

Chain

chain:1-389

Reference Genes

BioGPS Gene:9047 SH2D2A

COSMIC (genes):SH2D2A SH2D2A

CTD Gene:9047 SH2D2A

dbSNP Gene:9047 SH2D2A

ENSEMBL:ENSG00000027869 SH2D2A

ENSEMBL_homo_sapiens_GENE:ENSG00000027869.12 SH2D2A

HGNC:10821 SH2D2A

KEGG Gene (Homo sapiens):9047 SH2D2A

Monarch:9047 SH2D2A

NCBI Gene:9047 SH2D2A

OMIM:604514 SH2D2A

UCSC:Q9NP31 SH2D2A

Reference Transcript

Other Identifiers

11754777_a_at

16694764

207351_PM_s_at

207351_s_at

2438578

2438580

2438585

2438586

2438587

2438588

2438594

2438597

2438600

2438601

2438605

2438606

2438607

2438608

34432_at

7921144

9047

A_23_P160618

GE54437

GO:0001525

GO:0002376

GO:0005515

GO:0005737

GO:0005829

GO:0007165

GO:0017124

GO:0023052

GO:0030154

GO:0042098

GO:0048856

HMNXSV003003075

HMNXSV003034048

ILMN_1733874

PH_hs_0005748

TC01003354.hg

g4503632_3p_a_at

Participates

as an input of

p-6Y-VEGFR2 binds SH2D2A (Homo sapiens)

as a component of

VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Homo sapiens)

Inferred To

Ghost homologue of SH2D2A [cytosol] (Danio rerio)

SH2D2A [cytosol] (Bos taurus)

SH2D2A [cytosol] (Caenorhabditis elegans)

SH2D2A [cytosol] (Canis familiaris)

SH2D2A [cytosol] (Gallus gallus)

SH2D2A [cytosol] (Sus scrofa)

Homologues of SH2D2A [cytosol] (Caenorhabditis elegans)

Sh2d2a [cytosol] (Mus musculus)

Sh2d2a [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001154916.1, NP_003966.2, NP_001154914.1

OpenTargets

ENSG00000027869

GeneCards

Q9NP31

HPA

ENSG00000027869-SH2D2A

Ensembl

ENST00000392306, ENSP00000376123, ENST00000368199, ENSP00000357182, ENSG00000027869, ENSP00000357181, ENST00000368198

PRO

Q9NP31

Pharos - Targets

Q9NP31

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06239 LCK	4	p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.77	12
UniProt:Q5VU92 DC121			0.57	3
UniProt:Q9Y575 ASB3	1	ASB3 [cytosol] (R-HSA-975411)	0.57	3
UniProt:O95073-2 FSBP			0.57	3
UniProt:Q05397 PTK2	11	pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.57	3
UniProt:P27986-2 PIK3R1			0.57	3
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.57	4
UniProt:Q96A09 TET5B			0.57	3
UniProt:Q96IP4 TET5A			0.57	3
UniProt:Q9UF11-4 PLEKHB1			0.57	3
UniProt:P43405 SYK	6	p-Y-SYK [cytosol] (R-HSA-9705732) p-Y-SYK [plasma membrane] (R-HSA-429432) SYK [plasma membrane] (R-HSA-139844) p-6Y-SYK [cytosol] (R-HSA-1861712) p-Y348-SYK [cytosol] (R-HSA-437953) SYK [cytosol] (R-HSA-58268)	0.556	3
UniProt:Q14847 LASP1			0.508	2
UniProt:P11277 SPTB	1	SPTB [cytosol] (R-HSA-391565)	0.488	2
UniProt:P40763-2 STAT3			0.488	2
UniProt:Q92574 TSC1	2	TSC1 [plasma membrane] (R-HSA-165169) TSC1 [cytosol] (R-HSA-5672338)	0.488	2
UniProt:Q32MZ4-4 LRRFIP1			0.488	2
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.488	2
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.488	2
UniProt:Q9H4I2-2 ZHX3			0.488	2
UniProt:P46108-2 CRK			0.488	2
UniProt:Q6ZMI0 PPR21			0.488	2
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.488	2
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.488	2
UniProt:Q8NBB4 ZSCA1			0.488	2
UniProt:O14543 SOCS3	1	SOCS3 [cytosol] (R-HSA-873794)	0.488	2
UniProt:Q8TDQ0 HAVCR2	1	HAVCR2 [plasma membrane] (R-HSA-5340408)	0.462	3

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