Reactome | Phosphorylation of SRC-1

Phosphorylation of SRC-1

Stable Identifier

R-HSA-4420206

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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SRC is activated in vivo and in vitro in a VEGF/SH2D2A-dependent manner. VEGF induces phosphorylation of the activating Y418 residue, located on the c-SRC kinase activation loop, but also decreases phosphorylation of the negative regulatory Y527 (Sun et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22689825	VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd Abid, MR, Gualandi, L, Gustafsson, K, Li, X, Sun, Z, Claesson-Welsh, L, Sundvold-Gjerstad, V, Massena, S, Jansson, L, Choy, WW, Spurkland, A, Zang, G, Quach, M, Padhan, N, Kutschera, S, Phillipson, M	J. Exp. Med.	2012