Reactome | SLC39A1 [plasma membrane]

SLC39A1 [plasma membrane]

Stable Identifier

R-HSA-442329

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

hZIP1, Zinc transporter ZIP1, S39A1_HUMAN

Locations in the PathwayBrowser

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Transport of small molecules (Homo sapiens)

- SLC-mediated transmembrane transport (Homo sapiens)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
    - Metal ion SLC transporters (Homo sapiens)
      - Zinc transporters (Homo sapiens)
        
        Zinc influx into cells by the SLC39 gene family (Homo sapiens)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Homo sapiens)
        
        SLC39A1-4 [plasma membrane] (Homo sapiens)
        
        SLC39A1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NY26 SLC39A1

Gene Names

SLC39A1, IRT1, ZIP1, ZIRTL, CGI-08, CGI-71

Chain

chain:1-324

Reference Genes

BioGPS Gene:27173 SLC39A1

COSMIC (genes):SLC39A1 SLC39A1

CTD Gene:27173 SLC39A1

dbSNP Gene:27173 SLC39A1

ENSEMBL:ENSG00000143570 SLC39A1

HGNC:12876 SLC39A1

KEGG:hsa:27173 SLC39A1

Monarch:27173 SLC39A1

NCBI Gene:27173 SLC39A1

OMIM:604740 SLC39A1

UCSC:Q9NY26 SLC39A1

Reference Transcript

Other Identifiers

11715658_a_at

11745745_a_at

11748142_a_at

11748143_x_at

11750215_a_at

11750216_x_at

11751314_a_at

11751315_x_at

11754261_x_at

16693626

217778_PM_at

217778_at

2436373

2436374

2436375

2436376

2436377

2436379

2436380

2436381

2436382

2436383

2436384

2436385

2436386

2436387

2436388

2436389

2436390

2436391

2436392

2436393

2436394

2436397

2436399

27173

46281_at

7920401

GE55311

GO:0001701

GO:0005102

GO:0005215

GO:0005385

GO:0005515

GO:0005783

GO:0005789

GO:0005886

GO:0006812

GO:0006829

GO:0016020

GO:0022890

GO:0030001

GO:0043226

GO:0046873

GO:0048701

GO:0048856

GO:0055085

GO:0060173

GO:0071577

HMNXSV003032865

ILMN_2116714

PH_hs_0000810

TC01003281.hg

g7657700_3p_at

Participates

as a member of

SLC39A1-4 [plasma membrane] (Homo sapiens)

Inferred To

Homologues of SLC39A1 [plasma membrane] (Dictyostelium discoideum)

Homologues of SLC39A1 [plasma membrane] (Drosophila melanogaster)

Homologues of SLC39A1 [plasma membrane] (Plasmodium falciparum)

Zip42C.2 [plasma membrane] (Drosophila melanogaster)

Zip89B [plasma membrane] (Drosophila melanogaster)

ATX2 [plasma membrane] (Saccharomyces cerevisiae)

Zip42C.1 [plasma membrane] (Drosophila melanogaster)

zntD [plasma membrane] (Dictyostelium discoideum)

zntA [plasma membrane] (Dictyostelium discoideum)

Zip88E [plasma membrane] (Drosophila melanogaster)

SLC39A1 [plasma membrane] (Bos taurus)

SLC39A1 [plasma membrane] (Canis familiaris)

SLC39A1 [plasma membrane] (Plasmodium falciparum)

SLC39A1 [plasma membrane] (Sus scrofa)

Slc39a1 [plasma membrane] (Mus musculus)

Slc39a1 [plasma membrane] (Rattus norvegicus)

ZIP1 [plasma membrane] (Plasmodium falciparum)

zipt-1 [plasma membrane] (Caenorhabditis elegans)

slc39a1 [plasma membrane] (Danio rerio)

slc39a1 [plasma membrane] (Xenopus tropicalis)

Cross References

Guide to Pharmacology - Targets

1180

ENSEMBL

ENSP00000484182, ENST00000368623, ENST00000617697, ENST00000368621, ENST00000310483, ENSP00000309710, ENST00000621013, ENSP00000357612, ENSP00000479421, ENST00000356205, ENSP00000357610, ENSP00000348535

OpenTargets

ENSG00000143570

HPA

ENSG00000143570-SLC39A1

PRO

Q9NY26

Pharos - Targets

Q9NY26

HMDB Protein

HMDBP11934

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.556	3
UniProt:P21964 COMT	2	COMT [cytosol] (R-HSA-175974) COMT [plasma membrane] (R-HSA-379386)	0.556	3
UniProt:Q16581 C3AR1	3	C3AR1 [plasma membrane] (R-HSA-444727) C3AR1 [azurophil granule membrane] (R-HSA-6799517) C3AR1 [specific granule membrane] (R-HSA-6799516)	0.527	2
UniProt:P43115 PTGER3	1	PTGER3 [plasma membrane] (R-HSA-391828)	0.527	2

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