Reactome | SLC39A5 [plasma membrane]

SLC39A5 [plasma membrane]

Stable Identifier

R-HSA-442360

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

hZIP5, Zinc transporter ZIP5, S39A5_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q12891 HYAL2

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Transport of small molecules (Homo sapiens)

- SLC-mediated transmembrane transport (Homo sapiens)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
    - Metal ion SLC transporters (Homo sapiens)
      - Zinc transporters (Homo sapiens)
        
        Zinc influx into cells by the SLC39 gene family (Homo sapiens)
        
        hZIP5 mediates zinc uptake by cells (Homo sapiens)
        
        SLC39A5 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q6ZMH5 SLC39A5

Gene Names

SLC39A5, ZIP5

Chain

signal peptide:1-20, chain:21-540

Reference Genes

BioGPS Gene:283375 SLC39A5

COSMIC (genes):SLC39A5 SLC39A5

CTD Gene:283375 SLC39A5

dbSNP Gene:283375 SLC39A5

ENSEMBL:ENSG00000139540 SLC39A5

HGNC:20502 SLC39A5

KEGG:hsa:283375 SLC39A5

Monarch:283375 SLC39A5

NCBI Gene:283375 SLC39A5

OMIM:608730 SLC39A5

UCSC:Q6ZMH5 SLC39A5

Reference Transcript

Other Identifiers

11729744_a_at

1552281_3p_at

1552281_PM_at

1552281_at

16752602

231667_PM_at

231667_at

283375

3417499

3417501

3417502

3417503

3417504

3417505

3417506

3417507

3417508

3417509

3417510

3417511

3417512

3417513

3417514

3417515

3417516

3417517

3417518

3417519

3417520

3417521

3417522

3417523

3417524

3417530

56714_at

64246_at

7956229

A_14_P101806

A_23_P98876

A_33_P3385006

GE491196

GE711978

GO:0001654

GO:0003674

GO:0005215

GO:0005385

GO:0005886

GO:0006829

GO:0015701

GO:0016020

GO:0016323

GO:0030001

GO:0030003

GO:0030509

GO:0034224

GO:0043226

GO:0046873

GO:0048026

GO:0048856

GO:0055085

GO:0061351

GO:0070062

GO:0070315

GO:0071577

GO:0071578

GO:0140410

HMNXSV003011316

Hs.32699.0.A1_3p_at

Hs.32699.0.A1_3p_x_at

Hs2.32699.1.S1_3p_at

Hs2.32699.1.S1_3p_s_at

Hs2.32699.1.S1_3p_x_at

ILMN_1794951

PH_hs_0002754

TC12000508.hg

Cross References

Guide to Pharmacology - Targets

1184

OpenTargets

ENSG00000139540

ENSEMBL

ENST00000266980, ENSP00000266980, ENST00000454355, ENSP00000405360

HPA

ENSG00000139540-SLC39A5

PRO

Q6ZMH5

Pharos - Targets

Q6ZMH5

GlyGen

Q6ZMH5

HMDB Protein

HMDBP11938

PDB

7YF4, 7Y9C, 7YF2

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17706 PTPN2	3	p-PTPN2 [cytosol] (R-HSA-9836510) PTPN2 [cytosol] (R-HSA-997292) PTPN2 [nucleoplasm] (R-HSA-9008891)	0.527	2
UniProt:A0PJW6 TMEM223	1	TMEM223 [mitochondrial inner membrane] (R-HSA-9865797)	0.527	2
UniProt:Q9ULF5 SLC39A10	1	SLC39A10 [plasma membrane] (R-HSA-442377)	0.527	2
UniProt:Q9HD23 MRS2	1	MRS2 [mitochondrial inner membrane] (R-HSA-5216072)	0.527	2
UniProt:Q9P244 LRFN1	1	SALM2 [plasma membrane] (R-HSA-204734)	0.527	2
UniProt:P22455 FGFR4	12	p-5Y-FGFR4 [plasma membrane] (R-HSA-190330) FGFR4 [plasma membrane] (R-HSA-189921) p5Y-FGFR4 Y367C mutant [plasma membrane] (R-HSA-2011873) p-5Y-FGFR4 N535D [plasma membrane] (R-HSA-2038934) p-5Y-FGFR4 V550L [plasma membrane] (R-HSA-2038935) p-5Y-FGFR4 N535K [plasma membrane] (R-HSA-2038931) p-5Y-FGFR4 V550E [plasma membrane] (R-HSA-2038932) FGFR4 N535D [plasma membrane] (R-HSA-1614427) FGFR4 V550L [plasma membrane] (R-HSA-1614436) FGFR4 V550E [plasma membrane] (R-HSA-1614433) FGFR4 N535K [plasma membrane] (R-HSA-1614430) FGFR4 Y367C [plasma membrane] (R-HSA-1614439)	0.527	2
UniProt:Q12891 HYAL2	1	HYAL2 [plasma membrane] (R-HSA-2160919)	0.527	2
UniProt:Q9BZM4 ULBP3	1	ULBP3 [plasma membrane] (R-HSA-198076)	0.527	2
UniProt:Q9BRR3 PGAP4			0.527	2
UniProt:Q9H1U9 S2551			0.527	2
UniProt:Q7Z2K6 ERMP1			0.527	2
UniProt:P41273 TNFSF9	1	TNFSF9 [plasma membrane] (R-HSA-5667144)	0.527	2
UniProt:Q8WUY8 NAT14			0.527	2
UniProt:Q9H4A5 GLP3L			0.527	2
UniProt:Q8N4L2 PP4P2			0.527	2
UniProt:Q13433 SLC39A6	1	SLC39A6 [plasma membrane] (R-HSA-442332)	0.527	2
UniProt:Q9H1C7 CYSTM1	2	CYSTM1 [plasma membrane] (R-HSA-6800469) CYSTM1 [tertiary granule membrane] (R-HSA-6800410)	0.527	2
UniProt:Q9H4A6 GOLP3			0.527	2
UniProt:P98172 EFNB1	2	p-Y324,Y329,Y343-EFNB1 [plasma membrane] (R-HSA-3928412) EFNB1 [plasma membrane] (R-HSA-2682327)	0.527	2
UniProt:Q9BUJ0 ABHEA			0.527	2
UniProt:Q8WUD6 CHPT1	1	CHPT1 [Golgi membrane] (R-HSA-1498754)	0.527	2
UniProt:Q9H1A3 METL9			0.527	2
UniProt:Q96EU7 C1GALT1C1	6	C1GALT1C1 R68* [Golgi membrane] (R-HSA-6785530) C1GALT1C1 E152K [Golgi membrane] (R-HSA-6785515) C1GALT1C1 M1I [Golgi membrane] (R-HSA-6785518) C1GALT1C1 D131E [Golgi membrane] (R-HSA-6785521) C1GALT1C1 S193P [Golgi membrane] (R-HSA-6785527) C1GALT1C1 [Golgi membrane] (R-HSA-914016)	0.527	2
UniProt:Q96GP6 SREC2			0.527	2
UniProt:Q7Z4F1 LRP10	1	LRP10 [plasma membrane] (R-HSA-2424275)	0.527	2
UniProt:Q16394 EXT1	6	EXT1 R339L [Golgi membrane] (R-HSA-3730912) EXT1 L490Rfs9 [Golgi membrane] (R-HSA-3730975) EXT1 R340C [Golgi membrane] (R-HSA-3730974) EXT1 G339D [Golgi membrane] (R-HSA-3730910) EXT1 G198Afs54 [Golgi membrane] (R-HSA-3730971) EXT1 [Golgi membrane] (R-HSA-2022897)	0.527	2
UniProt:Q9UBQ6 EXTL2	1	EXTL2 [endoplasmic reticulum membrane] (R-HSA-8953372)	0.527	2
UniProt:Q6P1S2 CC033			0.527	2
UniProt:A8MVW0 F1712			0.527	2

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