Reactome | SLC39A7 [endoplasmic reticulum membrane]

SLC39A7 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-442363

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

ZIP7, HKE4, Zinc transporter SLC39A7, S39A7_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q92504 SLC39A7

Gene Names

SLC39A7, HKE4, RING5

Chain

chain:1-469

Reference Genes

BioGPS Gene:7922 SLC39A7

COSMIC (genes):SLC39A7 SLC39A7

CTD Gene:7922 SLC39A7

dbSNP Gene:7922 SLC39A7

ENSEMBL:ENSG00000112473 SLC39A7

HGNC:4927 SLC39A7

KEGG:hsa:7922 SLC39A7

Monarch:7922 SLC39A7

NCBI Gene:7922 SLC39A7

OMIM:601416 SLC39A7

UCSC:Q92504 SLC39A7

Reference Transcript

Other Identifiers

11721094_a_at

11721095_x_at

11750939_a_at

17007377

17007393

17028426

17028442

17031238

17031254

17033723

17033739

17035987

17036003

17038706

17038722

202667_PM_s_at

202667_s_at

2903471

2903472

2903473

2903474

2903475

2903476

2903477

2903478

2903480

2903481

2903482

2903483

2903484

2903485

2903487

2903489

2903490

2903491

2903492

2903504

40329_at

7922

8118613

8178225

8179525

A_14_P113533

A_23_P70571

D82060_at

GE81705

GO:0002376

GO:0005215

GO:0005385

GO:0005515

GO:0005654

GO:0005783

GO:0005789

GO:0005794

GO:0006829

GO:0006882

GO:0016020

GO:0030001

GO:0030154

GO:0030183

GO:0043226

GO:0046873

GO:0048856

GO:0055085

GO:0071577

GO:0098773

GO:0110075

HMNXSV003052712

ILMN_1778053

ILMN_2383077

PH_hs_0033242

TC06000412.hg

TC6_cox_hap2000102.hg

TC6_dbb_hap3000094.hg

TC6_mann_hap4000086.hg

TC6_mcf_hap5000087.hg

TC6_qbl_hap6000093.hg

g5901935_3p_a_at

Inferred To

slc39a7 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Slc39a7 [endoplasmic reticulum membrane] (Mus musculus)

zipt-7.2 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

SLC39A7 [endoplasmic reticulum membrane] (Bos taurus)

SLC39A7 [endoplasmic reticulum membrane] (Canis familiaris)

SLC39A7 [endoplasmic reticulum membrane] (Gallus gallus)

SLC39A7 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

SLC39A7 [endoplasmic reticulum membrane] (Sus scrofa)

Catsup [endoplasmic reticulum membrane] (Drosophila melanogaster)

YKE4 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

Cross References

Guide to Pharmacology - Targets

1186

OpenTargets

ENSG00000112473

ENSEMBL

ENSP00000372700, ENST00000456261, ENST00000441953, ENST00000441854, ENSP00000372701, ENSP00000403583, ENST00000423043, ENST00000418477, ENST00000431735, ENST00000416369, ENSP00000389623, ENSP00000410656, ENSP00000413027, ENSP00000363807, ENSP00000391735, ENST00000383214, ENST00000383213, ENST00000374677, ENST00000443773, ENST00000374675, ENSP00000416439, ENSP00000407093, ENSP00000414145, ENSP00000363809

HPA

ENSG00000112473-SLC39A7

PRO

Q92504

Pharos - Targets

Q92504

Orphanet

SLC39A7

HMDB Protein

HMDBP11940

PDB

8GZE

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.589	4
UniProt:Q13323 BIK			0.556	3
UniProt:Q6UXX9-2 RSPO2			0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:Q5TA78 LCE4A	1	LCE4A [cytosol] (R-HSA-6814272)	0.556	3
UniProt:Q9BYQ4 KRTAP9-2	1	KRTAP9-2 [cytosol] (R-HSA-6809965)	0.556	3
UniProt:Q5T7P2 LCE1A	1	LCE1A [cytosol] (R-HSA-6814305)	0.556	3
UniProt:Q9H3M0 KCNF1	1	KCNF1 [plasma membrane] (R-HSA-977450)	0.556	3
UniProt:Q5T754 LCE1F	1	LCE1F [cytosol] (R-HSA-6814270)	0.556	3
UniProt:Q9UGC6 RGS17	1	RGS17 [plasma membrane] (R-HSA-939779)	0.556	3
UniProt:Q6L8G8 KRTAP5-7	1	KRTAP5-7 [cytosol] (R-HSA-6810273)	0.556	3
UniProt:Q5T871 LELP1	1	LELP1 [cytosol] (R-HSA-6814302)	0.556	3
UniProt:O95436-2 SLC34A2			0.556	3
UniProt:Q8WWY7 WFD12			0.556	3
UniProt:Q5T751 LCE1C	1	LCE1C [cytosol] (R-HSA-6814267)	0.556	3
UniProt:Q5TCM9 LCE5A	1	LCE5A [cytosol] (R-HSA-6814260)	0.556	3
UniProt:Q86WB7-2 UNC93A			0.556	3
UniProt:Q9UBN6 TNFRSF10D	1	TNFRSF10D [plasma membrane] (R-HSA-5633374)	0.556	3
UniProt:Q9NUH8 TM14B			0.556	3
UniProt:P49901 MCSP			0.556	3
UniProt:Q3SXP7 SHSL1			0.556	3
IntAct:EBI-23667908 CCSB ORF ID			0.556	3
UniProt:O43610 SPY3			0.556	3
UniProt:Q9UGL9 CRCT1			0.556	3
UniProt:Q5TA81 LCE2C	1	LCE2C [cytosol] (R-HSA-6814284)	0.556	3
UniProt:P48165 GJA8	1	GJA8 [endoplasmic reticulum membrane] (R-HSA-190702)	0.556	3
UniProt:Q5TA82 LCE2D	1	LCE2D [cytosol] (R-HSA-6814300)	0.556	3
UniProt:Q8IUG1 KRTAP1-3	1	KRTAP1-3 [cytosol] (R-HSA-6809866)	0.556	3
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.527	2

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