Reactome | NCOR1 [nucleoplasm]

NCOR1 [nucleoplasm]

Stable Identifier

R-HSA-442501

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Nuclear receptor corepressor 1, NCOR1_HUMAN

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Locations in the PathwayBrowser for interactor IntAct:EBI-25907740 CCSB

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External Reference Information

External Reference

UniProt:O75376 NCOR1

Gene Names

NCOR1, KIAA1047

Chain

chain:1-2440

Reference Genes

COSMIC (genes):NCOR1 NCOR1

dbSNP Gene:9611 NCOR1

ENSEMBL:ENSG00000141027 NCOR1

Participates

as an input of

PPARG:RXRA heterodimer binds to PPARG corepressors (Homo sapiens)
NR1D1 (REV-ERBA) binds heme, the ELOVL3 gene, and recruits corepressors (Homo sapiens)
NR1D1 (REV-ERBA) binds heme, the NR1D1 gene, and recruits corepressors (Homo sapiens)
NR1D1 (REV-ERBA) binds heme, the CLOCK gene, and recruits corepressors (Homo sapiens)
NR1D1 (REV-ERBA) binds heme, the NPAS2 gene, and recruits corepressors (Homo sapiens)
NR1D1 (REV-ERBA) binds heme, the ARNTL gene, and recruits corepressors (Homo sapiens)
NR1D1 (REV-ERBA) binds heme, the PPARGC1A gene, and recruits corepressors (Homo sapiens)

as an output of

as a component of

as a member of

Other forms of this molecule

NCOR1 [cytosol]

Inferred To

Smr [nucleoplasm] (Drosophila melanogaster)

SNT1 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of NCOR1 [nucleoplasm] (Gallus gallus)

Ghost homologue of NCOR1 [nucleoplasm] (Rattus norvegicus)

Ncor1 [nucleoplasm] (Mus musculus)

gei-8 [nucleoplasm] (Caenorhabditis elegans)

NCOR1 [nucleoplasm] (Bos taurus)

NCOR1 [nucleoplasm] (Canis familiaris)

NCOR1 [nucleoplasm] (Sus scrofa)

ncor1 [nucleoplasm] (Xenopus tropicalis)

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10276 RARA	3	RARA [nucleoplasm] (R-HSA-446164) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830)	0.802	6
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.802	6
UniProt:Q06455 MTG8			0.72	5
UniProt:P12755 SKI	1	SKI [nucleoplasm] (R-HSA-173473)	0.669	4
UniProt:Q07869 PPARA	2	PPARA [nucleoplasm] (R-HSA-400186) monoSUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099)	0.658	3
UniProt:Q13133 NR1H3	1	NR1H3 [nucleoplasm] (R-HSA-8854957)	0.642	3
UniProt:P20393 NR1D1	1	NR1D1 [nucleoplasm] (R-HSA-375499)	0.602	3
UniProt:P37231 PPARG	2	monoSUMO1-K107,K395-PPARG [nucleoplasm] (R-HSA-4717444) PPARG [nucleoplasm] (R-HSA-446172)	0.571	2
UniProt:P10275 AR	4	AR [cytosol] (R-HSA-5618082) AR [nucleoplasm] (R-HSA-446174) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984)	0.569	4
UniProt:Q13263 TRIM28	3	TRIM28 [nucleoplasm] (R-HSA-974998) SUMO2-K554,K575,K676,K750,K779,K804-TRIM28 [nucleoplasm] (R-HSA-9842867) SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm] (R-HSA-3782600)	0.556	4
UniProt:Q99719 SEPT5			0.556	3
UniProt:P61764 STXBP1	2	STXBP1 [plasma membrane] (R-HSA-2980862) STXBP1 [cytosol] (R-HSA-6794256)	0.556	3
UniProt:I6L9F6 I6L9F6			0.556	3
IntAct:EBI-25907740 CCSB			0.556	3
UniProt:Q9UJC3 HOOK1			0.556	3
UniProt:Q8IUQ4-2 SIAH1			0.556	3
UniProt:P62937 PPIA	5	PPIA [extracellular exosome] (R-HSA-6801538) PPIA [ficolin-1-rich granule lumen] (R-HSA-6801391) PPIA [extracellular region] (R-HSA-173646) PPIA [secretory granule lumen] (R-HSA-6801400) PPIA [cytosol] (R-HSA-173123)	0.556	3
UniProt:Q9BQ87 TBL1Y			0.527	4
UniProt:P56524 HDAC4	3	polySUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029) monoSUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) HDAC4 [nucleoplasm] (R-HSA-351581)	0.527	2
UniProt:Q5SZD1 CF141			0.527	2
UniProt:Q9BUG6 ZSA5A			0.527	2
UniProt:Q13227 GPS2	1	GPS2 [nucleoplasm] (R-HSA-351642)	0.527	3
UniProt:P55055 NR1H2	3	NR1H2 [nucleoplasm] (R-HSA-375500) polySUMO2,3-K409,K447-NR1H2 [nucleoplasm] (R-HSA-4720435) NR1H2 [cytosol] (R-HSA-9619753)	0.525	6
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.524	3
UniProt:Q92922 SMARCC1	1	SMARCC1 [nucleoplasm] (R-HSA-389257)	0.524	3
UniProt:Q8TAQ2 SMARCC2	1	SMARCC2 [nucleoplasm] (R-HSA-389263)	0.524	3
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.524	2
UniProt:P06429 VE7			0.488	2
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.483	2