Reactome | NCOR1 [nucleoplasm]

NCOR1 [nucleoplasm]

Stable Identifier

R-HSA-442501

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Nuclear receptor corepressor 1, NCOR1_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:P56524 HDAC4

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External Reference Information

External Reference

UniProt:O75376 NCOR1

Gene Names

NCOR1, KIAA1047

Chain

chain:1-2440

Reference Genes

BioGPS Gene:9611 NCOR1

COSMIC (genes):NCOR1 NCOR1

CTD Gene:9611 NCOR1

dbSNP Gene:9611 NCOR1

ENSEMBL:ENSG00000141027 NCOR1

HGNC:7672 NCOR1

KEGG:hsa:9611 NCOR1

Monarch:9611 NCOR1

NCBI Gene:9611 NCOR1

OMIM:600849 NCOR1

UCSC:O75376 NCOR1

Reference Transcript

Participates

as an input of

as an output of

as a component of

as a member of

Other forms of this molecule

NCOR1 [cytosol]

Inferred To

Smr [nucleoplasm] (Drosophila melanogaster)

SNT1 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of NCOR1 [nucleoplasm] (Rattus norvegicus)

Ncor1 [nucleoplasm] (Mus musculus)

gei-8 [nucleoplasm] (Caenorhabditis elegans)

NCOR1 [nucleoplasm] (Bos taurus)

NCOR1 [nucleoplasm] (Canis familiaris)

NCOR1 [nucleoplasm] (Gallus gallus)

NCOR1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001177369.1, NP_001177367.1, XP_011522388.1, XP_054173929.1, NP_006302.2

ENSEMBL

ENST00000268712, ENST00000395851, ENSP00000379189, ENSP00000268712, ENSG00000141027, ENST00000395848, ENSP00000379192

OpenTargets

ENSG00000141027

GeneCards

NCOR1

HPA

ENSG00000141027-NCOR1

PRO

O75376

Pharos - Targets

O75376

GlyGen

O75376

PDB

6ZBU, 8AS9, 3KMZ, 6XYX, 6Y17, 8DKN, 8DKV, 6ONI, 4MDD, 8FKD, 6WMS, 8FKC, 3H52, 8D8I, 6XXS, 6WMQ, 6XZZ, 4WVD, 8FHE, 3N00, 8FKE, 8FHG, 8FKG, 8FKF, 2EQR

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10276 RARA	3	RARA [nucleoplasm] (R-HSA-446164) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830)	0.802	6
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.802	6
UniProt:Q06455 MTG8			0.72	5
UniProt:P12755 SKI	1	SKI [nucleoplasm] (R-HSA-173473)	0.669	4
UniProt:Q07869 PPARA	2	PPARA [nucleoplasm] (R-HSA-400186) monoSUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099)	0.658	3
UniProt:Q13227 GPS2	1	GPS2 [nucleoplasm] (R-HSA-351642)	0.643	4
UniProt:Q13133 NR1H3	1	NR1H3 [nucleoplasm] (R-HSA-8854957)	0.642	3
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.628	6
UniProt:P20393 NR1D1	1	NR1D1 [nucleoplasm] (R-HSA-375499)	0.602	3
UniProt:P37231 PPARG	2	PPARG [nucleoplasm] (R-HSA-446172) monoSUMO1-K107,K395-PPARG [nucleoplasm] (R-HSA-4717444)	0.571	2
UniProt:P10275 AR	4	AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984)	0.569	4
UniProt:Q13263 TRIM28	3	TRIM28 [nucleoplasm] (R-HSA-974998) SUMO2-K554,K575,K676,K750,K779,K804-TRIM28 [nucleoplasm] (R-HSA-9842867) SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm] (R-HSA-3782600)	0.556	4
UniProt:P62937 PPIA	5	PPIA [extracellular region] (R-HSA-173646) PPIA [secretory granule lumen] (R-HSA-6801400) PPIA [ficolin-1-rich granule lumen] (R-HSA-6801391) PPIA [cytosol] (R-HSA-173123) PPIA [extracellular exosome] (R-HSA-6801538)	0.556	3
UniProt:Q8IUQ4-2 SIAH1			0.556	3
UniProt:Q9UJC3 HOOK1			0.556	3
IntAct:EBI-25907740 CCSB			0.556	3
UniProt:I6L9F6 I6L9F6			0.556	3
UniProt:P61764 STXBP1	2	STXBP1 [cytosol] (R-HSA-6794256) STXBP1 [plasma membrane] (R-HSA-2980862)	0.556	3
UniProt:Q99719 SEPT5			0.556	3
UniProt:P56524 HDAC4	3	HDAC4 [nucleoplasm] (R-HSA-351581) monoSUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) polySUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029)	0.527	2
UniProt:Q9BUG6 ZSA5A			0.527	2
UniProt:Q5SZD1 CF141			0.527	2
UniProt:Q9BQ87 TBL1Y			0.527	4
UniProt:P55055 NR1H2	3	NR1H2 [nucleoplasm] (R-HSA-375500) polySUMO2,3-K409,K447-NR1H2 [nucleoplasm] (R-HSA-4720435) NR1H2 [cytosol] (R-HSA-9619753)	0.525	6
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.524	3
UniProt:Q92922 SMARCC1	1	SMARCC1 [nucleoplasm] (R-HSA-389257)	0.524	3
UniProt:Q8TAQ2 SMARCC2	1	SMARCC2 [nucleoplasm] (R-HSA-389263)	0.524	3
UniProt:P06429 VE7			0.488	2
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.483	2

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