Reactome | BAIAP2 [cytosol]

BAIAP2 [cytosol]

Stable Identifier

R-HSA-442574

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IRSp53/58, Brain-specific angiogenesis inhibitor 1-associated protein 2, BAIP2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UQB8 BAIAP2

Gene Names

BAIAP2

Chain

chain:1-552

Reference Genes

COSMIC (genes):BAIAP2 BAIAP2

dbSNP Gene:10458 BAIAP2

ENSEMBL:ENSG00000175866 BAIAP2

Participates

as a member of

as a candidate of

RAC3 effectors [cytosol] (Homo sapiens)

as a component of

as an input of

RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)

Inferred To

IRSp53 [cytosol] (Drosophila melanogaster)

Ghost homologue of BAIAP2 [cytosol] (Caenorhabditis elegans)

Ghost homologue of BAIAP2 [cytosol] (Dictyostelium discoideum)

Ghost homologue of BAIAP2 [cytosol] (Xenopus tropicalis)

Baiap2 [cytosol] (Mus musculus)

Baiap2 [cytosol] (Rattus norvegicus)

BAIAP2 [cytosol] (Bos taurus)

BAIAP2 [cytosol] (Canis familiaris)

BAIAP2 [cytosol] (Gallus gallus)

BAIAP2 [cytosol] (Sus scrofa)

Interactors (39)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.897	11
UniProt:Q12929 EPS8	1	EPS8 [cytosol] (R-HSA-9662382)	0.891	12
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.802	9
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.802	8
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.745	7
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.744	5
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.735	4
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.728	4
UniProt:Q9UHR4 BAIAP2L1	1	BAIAP2L1 [cytosol] (R-HSA-9693276)	0.708	5
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.706	6
UniProt:Q9NZQ3 NCKIPSD	1	NCKIPSD [cytosol] (R-HSA-2197671)	0.678	3
UniProt:Q8IZP0 ABI1	2	p-5S-ABI1 [cytosol] (R-HSA-2029034) ABI1 [cytosol] (R-HSA-1671643)	0.669	4
UniProt:Q92558 WASF1	3	WASF1 [cytosol] (R-HSA-200965) p-Y151-WASF1 [cytosol] (R-HSA-2029058) p-Y151,S,T-WASF1 [cytosol] (R-HSA-5672390)	0.659	3
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.649	7
UniProt:Q9Y6W5 WASF2	3	p-Y150,S343,T346-WASF2 [cytosol] (R-HSA-2130179) p-Y150-WASF2 [cytosol] (R-HSA-2130193) WASF2 [cytosol] (R-HSA-200972)	0.643	5
UniProt:Q7L576 CYFIP1	5	CYFIP1 [cytosol] (R-HSA-5672575) CYFIP1 [specific granule lumen] (R-HSA-6800167) CYFIP1 [extracellular region] (R-HSA-6800473) CYFIP1 [secretory granule lumen] (R-HSA-6800940) CYFIP1 [tertiary granule lumen] (R-HSA-6800176)	0.643	3
UniProt:Q08509 Eps8	1	Eps8 [cytosol] (R-MMU-9662412)	0.639	8
UniProt:Q14678 KANK1	3	KANK1 [nucleoplasm] (R-HSA-9018640) p-12Y-KANK1(1-899)-PDGFRB(415-1106) fusion [plasma membrane] (R-HSA-9673890) KANK1(1-899)-PDGFRB(415-1106) fusion [plasma membrane] (R-HSA-9673593)	0.639	6
UniProt:P54259 ATN1	1	ATN1 [nucleoplasm] (R-HSA-6807083)	0.635	3
UniProt:Q03173 Enah	2	Enah [cytosol] (R-MMU-430212) Enah [cytosol] (R-MMU-426406)	0.591	3
UniProt:P60953 CDC42	3	CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086)	0.573	2
UniProt:P60709 ACTB	5	ACTB [plasma membrane] (R-HSA-196016) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [cytosol] (R-HSA-201861) ACTB [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462)	0.564	2
UniProt:Q9NZ81 PRR13			0.556	3
UniProt:Q13625-3 TP53BP2			0.556	3
UniProt:Q9UFG5 CS025			0.556	3
UniProt:Q15427 SF3B4	1	SF3B4 [nucleoplasm] (R-HSA-71975)	0.556	3
UniProt:O00401 WASL	4	p-Y256-WASL [cytosol] (R-HSA-2197672) N-WASP [cytosol] (R-HSA-201873) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.547	2
UniProt:Q9Y2A7 NCKAP1	1	NCKAP1 [cytosol] (R-HSA-200979)	0.527	3
UniProt:Q8CFN2 Cdc42	3	CDC42 [endoplasmic reticulum membrane] (R-RNO-5672086) CDC42 [plasma membrane] (R-RNO-449545) Cdc42 [cytosol] (R-RNO-428464)	0.527	2
UniProt:Q9NYB9 ABI2	2	p-4S-ABI2 [cytosol] (R-HSA-2029003) ABI2 [cytosol] (R-HSA-1671647)	0.527	2
UniProt:Q9P206 NHSL3			0.527	4
UniProt:Q8WUW1 BRK1	1	BRK1 [cytosol] (R-HSA-1671645)	0.527	2
UniProt:Q96F07 CYFIP2	1	CYFIP2 [cytosol] (R-HSA-1671642)	0.527	2
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	6
UniProt:Q7DB77 TIR			0.508	3
UniProt:P60953-2 CDC42			0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	6
UniProt:P01116 KRAS	20	S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674814) p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674821) KRAS A146T [plasma membrane] (R-HSA-9649623) KRAS K147E [plasma membrane] (R-HSA-9651169) KRAS K147T [plasma membrane] (R-HSA-9651180) KRAS V14G [plasma membrane] (R-HSA-9651295) KRAS K147N [plasma membrane] (R-HSA-9651177) KRAS A146V [plasma membrane] (R-HSA-9649626) KRAS A146S [plasma membrane] (R-HSA-9649621) KRAS A146P [plasma membrane] (R-HSA-9649617) KRAS P34R [plasma membrane] (R-HSA-9651276) KRAS P34L [plasma membrane] (R-HSA-9651269) KRAS G12A [plasma membrane] (R-HSA-9649088) KRAS G12R [plasma membrane] (R-HSA-9649090) KRAS G13V [plasma membrane] (R-HSA-9649644) KRAS G13S [plasma membrane] (R-HSA-9649642) KRAS G13C [plasma membrane] (R-HSA-9649636) KRAS G13R [plasma membrane] (R-HSA-9649639) KRAS G13A [plasma membrane] (R-HSA-9649632) KRAS K5N [plasma membrane] (R-HSA-9651361)	0.483	2
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.471	4

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