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BAIAP2 [cytosol]
Stable Identifier
R-HSA-442574
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
IRSp53/58, Brain-specific angiogenesis inhibitor 1-associated protein 2, BAIP2_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P01116 KRAS
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
BAIAP2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
BAIAP2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
BAIAP2 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
BAIAP2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UQB8 BAIAP2
Gene Names
BAIAP2
Chain
chain:1-552
Reference Genes
COSMIC (genes):BAIAP2 BAIAP2
dbSNP Gene:10458 BAIAP2
ENSEMBL:ENSG00000175866 BAIAP2
Participates
as a member of
CDC42 effectors [cytosol] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
as a candidate of
RAC3 effectors [cytosol] (Homo sapiens)
as a component of
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
as an input of
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
Inferred To
IRSp53 [cytosol]
(Drosophila melanogaster)
Ghost homologue of BAIAP2 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of BAIAP2 [cytosol]
(Dictyostelium discoideum)
Ghost homologue of BAIAP2 [cytosol]
(Xenopus tropicalis)
Baiap2 [cytosol]
(Mus musculus)
Baiap2 [cytosol]
(Rattus norvegicus)
BAIAP2 [cytosol]
(Bos taurus)
BAIAP2 [cytosol]
(Canis familiaris)
BAIAP2 [cytosol]
(Gallus gallus)
BAIAP2 [cytosol]
(Sus scrofa)
Interactors (39)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.897
11
UniProt:Q12929 EPS8
1
EPS8 [cytosol]
(R-HSA-9662382)
0.891
12
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.802
9
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.802
8
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.745
7
UniProt:Q9UQB8 BAIAP2
1
BAIAP2 [cytosol]
(R-HSA-442574)
0.744
5
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.735
4
UniProt:P63000 RAC1
6
RAC1 [plasma membrane]
(R-HSA-351141)
RAC1 [cytosol]
(R-HSA-442615)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
0.728
4
UniProt:Q9UHR4 BAIAP2L1
1
BAIAP2L1 [cytosol]
(R-HSA-9693276)
0.708
5
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.706
6
UniProt:Q9NZQ3 NCKIPSD
1
NCKIPSD [cytosol]
(R-HSA-2197671)
0.678
3
UniProt:Q8IZP0 ABI1
2
p-5S-ABI1 [cytosol]
(R-HSA-2029034)
ABI1 [cytosol]
(R-HSA-1671643)
0.669
4
UniProt:Q92558 WASF1
3
WASF1 [cytosol]
(R-HSA-200965)
p-Y151-WASF1 [cytosol]
(R-HSA-2029058)
p-Y151,S,T-WASF1 [cytosol]
(R-HSA-5672390)
0.659
3
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.649
7
UniProt:Q9Y6W5 WASF2
3
p-Y150,S343,T346-WASF2 [cytosol]
(R-HSA-2130179)
p-Y150-WASF2 [cytosol]
(R-HSA-2130193)
WASF2 [cytosol]
(R-HSA-200972)
0.643
5
UniProt:Q7L576 CYFIP1
5
CYFIP1 [cytosol]
(R-HSA-5672575)
CYFIP1 [specific granule lumen]
(R-HSA-6800167)
CYFIP1 [extracellular region]
(R-HSA-6800473)
CYFIP1 [secretory granule lumen]
(R-HSA-6800940)
CYFIP1 [tertiary granule lumen]
(R-HSA-6800176)
0.643
3
UniProt:Q08509 Eps8
1
Eps8 [cytosol]
(R-MMU-9662412)
0.639
8
UniProt:Q14678 KANK1
3
KANK1 [nucleoplasm]
(R-HSA-9018640)
p-12Y-KANK1(1-899)-PDGFRB(415-1106) fusion [plasma membrane]
(R-HSA-9673890)
KANK1(1-899)-PDGFRB(415-1106) fusion [plasma membrane]
(R-HSA-9673593)
0.639
6
UniProt:P54259 ATN1
1
ATN1 [nucleoplasm]
(R-HSA-6807083)
0.635
3
UniProt:Q03173 Enah
2
Enah [cytosol]
(R-MMU-430212)
Enah [cytosol]
(R-MMU-426406)
0.591
3
UniProt:P60953 CDC42
3
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [plasma membrane]
(R-HSA-449545)
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
0.573
2
UniProt:P60709 ACTB
5
ACTB [plasma membrane]
(R-HSA-196016)
ACTB [lysosomal membrane]
(R-HSA-196160)
ACTB [cytosol]
(R-HSA-201861)
ACTB [nucleoplasm]
(R-HSA-3321990)
Unfolded ACTB [cytosol]
(R-HSA-390462)
0.564
2
UniProt:Q9NZ81 PRR13
0.556
3
UniProt:Q13625-3 TP53BP2
0.556
3
UniProt:Q9UFG5 CS025
0.556
3
UniProt:Q15427 SF3B4
1
SF3B4 [nucleoplasm]
(R-HSA-71975)
0.556
3
UniProt:O00401 WASL
4
p-Y256-WASL [cytosol]
(R-HSA-2197672)
N-WASP [cytosol]
(R-HSA-201873)
WASL [plasma membrane]
(R-HSA-203010)
WASL [endocytic vesicle membrane]
(R-HSA-535012)
0.547
2
UniProt:Q9Y2A7 NCKAP1
1
NCKAP1 [cytosol]
(R-HSA-200979)
0.527
3
UniProt:Q8CFN2 Cdc42
3
CDC42 [endoplasmic reticulum membrane]
(R-RNO-5672086)
CDC42 [plasma membrane]
(R-RNO-449545)
Cdc42 [cytosol]
(R-RNO-428464)
0.527
2
UniProt:Q9NYB9 ABI2
2
p-4S-ABI2 [cytosol]
(R-HSA-2029003)
ABI2 [cytosol]
(R-HSA-1671647)
0.527
2
UniProt:Q9P206 NHSL3
0.527
4
UniProt:Q8WUW1 BRK1
1
BRK1 [cytosol]
(R-HSA-1671645)
0.527
2
UniProt:Q96F07 CYFIP2
1
CYFIP2 [cytosol]
(R-HSA-1671642)
0.527
2
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
6
UniProt:Q7DB77 TIR
0.508
3
UniProt:P60953-2 CDC42
0.508
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
6
UniProt:P01116 KRAS
20
S-Farn-Me-PalmS KRAS [plasma membrane]
(R-HSA-9674814)
p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane]
(R-HSA-9674821)
KRAS A146T [plasma membrane]
(R-HSA-9649623)
KRAS K147E [plasma membrane]
(R-HSA-9651169)
KRAS K147T [plasma membrane]
(R-HSA-9651180)
KRAS V14G [plasma membrane]
(R-HSA-9651295)
KRAS K147N [plasma membrane]
(R-HSA-9651177)
KRAS A146V [plasma membrane]
(R-HSA-9649626)
KRAS A146S [plasma membrane]
(R-HSA-9649621)
KRAS A146P [plasma membrane]
(R-HSA-9649617)
KRAS P34R [plasma membrane]
(R-HSA-9651276)
KRAS P34L [plasma membrane]
(R-HSA-9651269)
KRAS G12A [plasma membrane]
(R-HSA-9649088)
KRAS G12R [plasma membrane]
(R-HSA-9649090)
KRAS G13V [plasma membrane]
(R-HSA-9649644)
KRAS G13S [plasma membrane]
(R-HSA-9649642)
KRAS G13C [plasma membrane]
(R-HSA-9649636)
KRAS G13R [plasma membrane]
(R-HSA-9649639)
KRAS G13A [plasma membrane]
(R-HSA-9649632)
KRAS K5N [plasma membrane]
(R-HSA-9651361)
0.483
2
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.471
4
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