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BAIAP2 [cytosol]
Stable Identifier
R-HSA-442574
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
IRSp53/58, Brain-specific angiogenesis inhibitor 1-associated protein 2, BAIP2_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q8IZP0 ABI1
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
BAIAP2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
BAIAP2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
BAIAP2 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
BAIAP2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UQB8 BAIAP2
Gene Names
BAIAP2
Chain
chain:1-552
Reference Genes
BioGPS Gene:10458 BAIAP2
COSMIC (genes):BAIAP2 BAIAP2
CTD Gene:10458 BAIAP2
dbSNP Gene:10458 BAIAP2
ENSEMBL:ENSG00000175866 BAIAP2
ENSEMBL_homo_sapiens_GENE:ENSG00000175866.16 BAIAP2
HGNC:947 BAIAP2
KEGG Gene (Homo sapiens):10458 BAIAP2
Monarch:10458 BAIAP2
NCBI Gene:10458 BAIAP2
OMIM:605475 BAIAP2
UCSC:Q9UQB8 BAIAP2
Reference Transcript
RefSeq:NM_006340.2 BAIAP2
RefSeq:XM_005256948.3 BAIAP2
RefSeq:NM_017451.2 BAIAP2
RefSeq:NM_001144888.1 BAIAP2
RefSeq:NM_017450.2 BAIAP2
Other Identifiers
10458
11722718_a_at
11722719_s_at
11722720_at
11726574_a_at
11739607_a_at
11749800_a_at
11749801_x_at
11754668_x_at
11762496_x_at
11762757_a_at
11762758_x_at
16838750
205293_PM_x_at
205293_x_at
205294_PM_at
205294_at
207832_PM_at
207832_at
209502_PM_s_at
209502_s_at
3737698
3737699
3737700
3737717
3737720
3737730
3737732
3737733
3737741
3737744
3737745
3737746
3737747
3737749
3737750
3737751
3737753
3737754
3737755
3737756
3737758
3737763
3737764
3737765
3737766
37761_at
8010562
A_24_P159648
GE53407
GO:0001221
GO:0001726
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0005874
GO:0005886
GO:0005912
GO:0007009
GO:0007010
GO:0007155
GO:0007409
GO:0008093
GO:0008286
GO:0008360
GO:0010976
GO:0015629
GO:0016020
GO:0016358
GO:0023052
GO:0030027
GO:0030141
GO:0030154
GO:0030165
GO:0030175
GO:0030182
GO:0030838
GO:0031410
GO:0032956
GO:0034330
GO:0035418
GO:0042802
GO:0042995
GO:0043005
GO:0043025
GO:0043197
GO:0043198
GO:0043226
GO:0044306
GO:0048167
GO:0048856
GO:0050804
GO:0050877
GO:0051017
GO:0051764
GO:0060076
GO:0060090
GO:0061003
GO:0061024
GO:0061845
GO:0061846
GO:0065003
GO:0070062
GO:0070064
GO:0071364
GO:0097060
GO:0097110
GO:0098609
GO:0098631
GO:0098641
GO:0098685
GO:0098793
GO:0098794
GO:0098978
GO:0099092
GO:0099175
GO:0099523
GO:0099524
GO:1905232
GO:1905274
GO:2000463
HMNXSV003014516
HMNXSV003026596
HMNXSV003056908
ILMN_1699727
ILMN_1705922
ILMN_2258749
PH_hs_0022412
TC17000924.hg
g12803352_3p_a_at
g4239983_3p_s_at
g9257198_3p_at
Participates
as a member of
CDC42 effectors [cytosol] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
as a candidate of
RAC3 effectors [cytosol] (Homo sapiens)
as an input of
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
as a component of
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
Inferred To
IRSp53 [cytosol]
(Drosophila melanogaster)
Ghost homologue of BAIAP2 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of BAIAP2 [cytosol]
(Dictyostelium discoideum)
Ghost homologue of BAIAP2 [cytosol]
(Xenopus tropicalis)
Baiap2 [cytosol]
(Mus musculus)
Baiap2 [cytosol]
(Rattus norvegicus)
BAIAP2 [cytosol]
(Bos taurus)
BAIAP2 [cytosol]
(Canis familiaris)
BAIAP2 [cytosol]
(Gallus gallus)
BAIAP2 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_006331.1
,
NP_059344.1
,
NP_001138360.1
,
XP_005257005.1
,
NP_059345.1
OpenTargets
ENSG00000175866
GeneCards
Q9UQB8
HPA
ENSG00000175866-BAIAP2
Ensembl
ENSP00000316338
,
ENSP00000458964
,
ENST00000435091
,
ENST00000428708
,
ENSP00000401022
,
ENSP00000413069
,
ENSG00000175866
,
ENST00000575712
,
ENST00000321280
,
ENST00000321300
,
ENSP00000315685
PRO
Q9UQB8
Pharos - Targets
Q9UQB8
HMDB Protein
HMDBP08316
PDB
1WDZ
,
6ZEG
,
6BCR
,
1Y2O
,
3RNJ
,
6ZEI
,
6BD1
,
6BQT
,
6BCY
,
6BD2
,
4JS0
,
2YKT
Interactors (39)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.897
11
UniProt:Q12929 EPS8
1
EPS8 [cytosol]
(R-HSA-9662382)
0.891
12
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.802
9
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.802
8
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.745
7
UniProt:Q9UQB8 BAIAP2
1
BAIAP2 [cytosol]
(R-HSA-442574)
0.744
5
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.735
4
UniProt:P63000 RAC1
6
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.728
4
UniProt:Q9UHR4 BAIAP2L1
1
BAIAP2L1 [cytosol]
(R-HSA-9693276)
0.708
5
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.706
6
UniProt:Q9NZQ3 NCKIPSD
1
NCKIPSD [cytosol]
(R-HSA-2197671)
0.678
3
UniProt:Q8IZP0 ABI1
2
p-5S-ABI1 [cytosol]
(R-HSA-2029034)
ABI1 [cytosol]
(R-HSA-1671643)
0.669
4
UniProt:Q92558 WASF1
3
WASF1 [cytosol]
(R-HSA-200965)
p-Y151,S,T-WASF1 [cytosol]
(R-HSA-5672390)
p-Y151-WASF1 [cytosol]
(R-HSA-2029058)
0.659
3
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.649
7
UniProt:Q9Y6W5 WASF2
3
WASF2 [cytosol]
(R-HSA-200972)
p-Y150,S343,T346-WASF2 [cytosol]
(R-HSA-2130179)
p-Y150-WASF2 [cytosol]
(R-HSA-2130193)
0.643
5
UniProt:Q7L576 CYFIP1
5
CYFIP1 [specific granule lumen]
(R-HSA-6800167)
CYFIP1 [secretory granule lumen]
(R-HSA-6800940)
CYFIP1 [extracellular region]
(R-HSA-6800473)
CYFIP1 [tertiary granule lumen]
(R-HSA-6800176)
CYFIP1 [cytosol]
(R-HSA-5672575)
0.643
3
UniProt:Q08509 Eps8
1
Eps8 [cytosol]
(R-MMU-9662412)
0.639
8
UniProt:Q14678 KANK1
3
KANK1 [nucleoplasm]
(R-HSA-9018640)
p-12Y-KANK1(1-899)-PDGFRB(415-1106) fusion [plasma membrane]
(R-HSA-9673890)
KANK1(1-899)-PDGFRB(415-1106) fusion [plasma membrane]
(R-HSA-9673593)
0.639
6
UniProt:P54259 ATN1
1
ATN1 [nucleoplasm]
(R-HSA-6807083)
0.635
3
UniProt:Q03173 Enah
2
Enah [cytosol]
(R-MMU-430212)
Enah [cytosol]
(R-MMU-426406)
0.591
3
UniProt:P60953 CDC42
3
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [plasma membrane]
(R-HSA-449545)
0.573
2
UniProt:P60709 ACTB
5
Unfolded ACTB [cytosol]
(R-HSA-390462)
ACTB [nucleoplasm]
(R-HSA-3321990)
ACTB [cytosol]
(R-HSA-201861)
ACTB [lysosomal membrane]
(R-HSA-196160)
ACTB [plasma membrane]
(R-HSA-196016)
0.564
2
UniProt:Q9NZ81 PRR13
0.556
3
UniProt:Q13625-3 TP53BP2
0.556
3
UniProt:Q9UFG5 CS025
0.556
3
UniProt:Q15427 SF3B4
1
SF3B4 [nucleoplasm]
(R-HSA-71975)
0.556
3
UniProt:O00401 WASL
4
N-WASP [cytosol]
(R-HSA-201873)
p-Y256-WASL [cytosol]
(R-HSA-2197672)
WASL [plasma membrane]
(R-HSA-203010)
WASL [endocytic vesicle membrane]
(R-HSA-535012)
0.547
2
UniProt:Q9Y2A7 NCKAP1
1
NCKAP1 [cytosol]
(R-HSA-200979)
0.527
3
UniProt:Q9NYB9 ABI2
2
ABI2 [cytosol]
(R-HSA-1671647)
p-4S-ABI2 [cytosol]
(R-HSA-2029003)
0.527
2
UniProt:Q9P206 NHSL3
0.527
4
UniProt:Q8WUW1 BRK1
1
BRK1 [cytosol]
(R-HSA-1671645)
0.527
2
UniProt:Q96F07 CYFIP2
1
CYFIP2 [cytosol]
(R-HSA-1671642)
0.527
2
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
6
UniProt:Q8CFN2 Cdc42
3
CDC42 [endoplasmic reticulum membrane]
(R-RNO-5672086)
Cdc42 [cytosol]
(R-RNO-428464)
CDC42 [plasma membrane]
(R-RNO-449545)
0.527
2
UniProt:Q7DB77 TIR
0.508
3
UniProt:P60953-2 CDC42
0.508
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
6
UniProt:P01116 KRAS
20
S-Farn-Me-PalmS KRAS [plasma membrane]
(R-HSA-9674814)
p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane]
(R-HSA-9674821)
KRAS A146T [plasma membrane]
(R-HSA-9649623)
KRAS K147E [plasma membrane]
(R-HSA-9651169)
KRAS K147T [plasma membrane]
(R-HSA-9651180)
KRAS V14G [plasma membrane]
(R-HSA-9651295)
KRAS K147N [plasma membrane]
(R-HSA-9651177)
KRAS A146V [plasma membrane]
(R-HSA-9649626)
KRAS A146S [plasma membrane]
(R-HSA-9649621)
KRAS A146P [plasma membrane]
(R-HSA-9649617)
KRAS P34R [plasma membrane]
(R-HSA-9651276)
KRAS P34L [plasma membrane]
(R-HSA-9651269)
KRAS G12A [plasma membrane]
(R-HSA-9649088)
KRAS G12R [plasma membrane]
(R-HSA-9649090)
KRAS G13V [plasma membrane]
(R-HSA-9649644)
KRAS G13S [plasma membrane]
(R-HSA-9649642)
KRAS G13C [plasma membrane]
(R-HSA-9649636)
KRAS G13R [plasma membrane]
(R-HSA-9649639)
KRAS G13A [plasma membrane]
(R-HSA-9649632)
KRAS K5N [plasma membrane]
(R-HSA-9651361)
0.483
2
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.471
4
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