Reactome | CDC42 [cytosol]

CDC42 [cytosol]

Stable Identifier

R-HSA-442630

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cell division control protein 42 homolog, CDC42_HUMAN

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Parasite infection (Homo sapiens)
        
        Leishmania phagocytosis (Homo sapiens)
        
        FCGR3A-mediated phagocytosis (Homo sapiens)
        
        An unknown GEF exchanges GTP for GDP on CDC42:GDP (Homo sapiens)
        
        CDC42:GDP [cytosol] (Homo sapiens)
        
        CDC42 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P60953 CDC42

Gene Names

CDC42, cell division cycle 42

Chain

chain:1-188, propeptide:189-191

Reference Genes

BioGPS Gene:998 CDC42

COSMIC (genes):CDC42 CDC42

CTD Gene:998 CDC42

dbSNP Gene:998 CDC42

ENSEMBL:ENSG00000070831 CDC42

ENSEMBL_homo_sapiens_GENE:ENSG00000070831.18 CDC42

HGNC:1736 CDC42

KEGG Gene (Homo sapiens):998 CDC42

Monarch:998 CDC42

NCBI Gene:998 CDC42

OMIM:116952 CDC42

UCSC:P60953 CDC42

Reference Transcript

Other Identifiers

11721885_s_at

11721886_a_at

11725717_at

11725718_a_at

11725719_s_at

11725720_x_at

11729102_x_at

11753606_x_at

11756249_x_at

16660503

208727_PM_s_at

208727_s_at

208728_3p_s_at

208728_PM_s_at

208728_s_at

210232_PM_at

210232_at

214230_PM_at

214230_at

2324635

2324636

2324637

2324638

2324639

2324640

2324643

2324646

2324647

2324650

2324652

2324653

2324654

2324660

2324661

2324662

2324663

2324664

2324665

2324666

2324667

2324668

2324669

2324670

2324671

2324672

2324680

2324682

2324684

2324685

2763403

2763404

2763405

2763406

2763408

2763409

3003101

3003102

3003104

3003106

3051737

3119340

39736_at

4006960

7898739

959_at

960_g_at

998

A_14_P125675

A_19_P00330417

A_23_P200560

A_23_P300056

A_24_P42633

A_24_P453532

GE510780

GE57603

GE86095

GO:0000139

GO:0000166

GO:0000278

GO:0000322

GO:0000910

GO:0002040

GO:0002376

GO:0003013

GO:0003015

GO:0003161

GO:0003253

GO:0003824

GO:0003924

GO:0003925

GO:0005515

GO:0005525

GO:0005576

GO:0005615

GO:0005737

GO:0005773

GO:0005783

GO:0005789

GO:0005794

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005886

GO:0005911

GO:0005925

GO:0005938

GO:0006260

GO:0006886

GO:0006897

GO:0006911

GO:0007010

GO:0007015

GO:0007018

GO:0007030

GO:0007059

GO:0007088

GO:0007097

GO:0007155

GO:0007163

GO:0007229

GO:0007264

GO:0007399

GO:0008104

GO:0009653

GO:0010591

GO:0010592

GO:0012501

GO:0016020

GO:0016192

GO:0016740

GO:0016787

GO:0017119

GO:0019901

GO:0021762

GO:0023052

GO:0030036

GO:0030141

GO:0030154

GO:0030175

GO:0030225

GO:0030307

GO:0030335

GO:0030425

GO:0030496

GO:0030742

GO:0031252

GO:0031256

GO:0031274

GO:0031333

GO:0031410

GO:0031435

GO:0031996

GO:0032427

GO:0032467

GO:0032488

GO:0032956

GO:0032991

GO:0034191

GO:0034329

GO:0034330

GO:0034332

GO:0035050

GO:0035088

GO:0036336

GO:0036464

GO:0038189

GO:0042802

GO:0042995

GO:0043005

GO:0043025

GO:0043197

GO:0043226

GO:0043227

GO:0043410

GO:0043525

GO:0044788

GO:0045177

GO:0045198

GO:0045335

GO:0045740

GO:0046330

GO:0046847

GO:0048549

GO:0048664

GO:0048856

GO:0048870

GO:0051130

GO:0051233

GO:0051489

GO:0051491

GO:0051492

GO:0051496

GO:0051647

GO:0051649

GO:0051683

GO:0051835

GO:0051897

GO:0051988

GO:0060047

GO:0060071

GO:0060501

GO:0060661

GO:0060997

GO:0061024

GO:0061630

GO:0065003

GO:0070062

GO:0071346

GO:0071944

GO:0072384

GO:0072686

GO:0086101

GO:0090135

GO:0090316

GO:0098542

GO:0098685

GO:0098772

GO:0098978

GO:0099159

GO:0099175

GO:0099563

GO:0140014

GO:0140096

GO:1900026

HMNXSV003001828

HMNXSV003003678

HMNXSV003026991

HMNXSV003045847

Hs.146409.3.S1_3p_at

Hs2.384596.1.S1_3p_at

ILMN_1675156

ILMN_1696041

ILMN_1738424

ILMN_2408139

PH_hs_0029852

PH_hs_0040005

TC01000280.hg

g12803746_3p_a_at

g13277547_3p_at

g13277547_3p_s_at

g182856_3p_at

Participates

as a candidate of

as a member of

RAC1, CDC42 [cytosol] (Homo sapiens)

as a component of

Other forms of this molecule

CDC42 [endoplasmic reticulum membrane]

CDC42 [plasma membrane]

Inferred To

CDC42 [cytosol] (Bos taurus)

CDC42 [cytosol] (Caenorhabditis elegans)

CDC42 [cytosol] (Canis familiaris)

CDC42 [cytosol] (Dictyostelium discoideum)

CDC42 [cytosol] (Drosophila melanogaster)

CDC42 [cytosol] (Gallus gallus)

CDC42 [cytosol] (Mus musculus)

CDC42 [cytosol] (Saccharomyces cerevisiae)

CDC42 [cytosol] (Schizosaccharomyces pombe)

CDC42 [cytosol] (Sus scrofa)

cdc42 [cytosol] (Danio rerio)

cdc42 [cytosol] (Xenopus tropicalis)

Cdc42 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001782.1, NP_001034891.1, NP_426359.1

OpenTargets

ENSG00000070831

ZINC - Substances

CDC42_HUMAN

ZINC target

P60953

ZINC - Biogenic

CDC42_HUMAN

PRO

P60953

PDB

5UPK, 1DOA, 4DID, 2WMO, 2WMN, 6TKZ, 6TKY, 1GZS, 1GRN, 6AJ4, 1E0A, 5UPL, 2QRZ, 4YDH, 8I5F, 4YC7, 3QBV, 1CF4, 2KB0, 1KZG, 3GCG, 2WM9, 3VHL, 5CJP, 2ASE, 6SUP, 1A4R, 5HZK, 2DFK, 2NGR, 1KI1, 1NF3, 1AM4, 6AJL, 1EES, 7S0Y, 4JS0, 5FI1, 6SIU, 4ITR, 1AJE, 2ODB, 1KZ7, 1AN0, 1CEE

IntEnz

3.6.5.2

GeneCards

P60953

HPA

ENSG00000070831-CDC42

Ensembl

ENSP00000314458, ENSP00000512180, ENSP00000512182, ENST00000411827, ENST00000400259, ENST00000344548, ENSP00000398327, ENSP00000383118, ENSP00000341072, ENSP00000512222, ENSP00000512225, ENST00000695800, ENST00000315554, ENSP00000512179, ENSP00000512178, ENSP00000512177, ENSP00000512176, ENST00000695860, ENST00000695802, ENST00000662562, ENSG00000070831, ENSP00000499457, ENST00000695797, ENST00000695796, ENSP00000499612, ENST00000695799, ENST00000695798, ENST00000695857, ENST00000656825

Pharos - Targets

P60953

ZINC - Predictions - Purchasable

CDC42_HUMAN

Orphanet

24399

HMDB Protein

HMDBP01784

Interactors (52)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.957	19
UniProt:P42768 WAS	2	WAS [cytosol] (R-HSA-201879) p-Y291-WAS [cytosol] (R-HSA-2197668)	0.949	14
UniProt:Q13153 PAK1	5	PAK1 [plasma membrane] (R-HSA-3928409) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) Active PAK1 [cytosol] (R-HSA-8964622) PAK1 [cytosol] (R-HSA-162629) p-S144,T423-PAK1 [cytosol] (R-HSA-399819)	0.944	15
UniProt:Q9BYG5 PARD6B	2	PARD6B [plasma membrane] (R-HSA-418193) PARD6B [cytosol] (R-HSA-419973)	0.896	18
UniProt:Q00587 CDC42EP1	1	CDC42EP1 [cytosol] (R-HSA-9691382)	0.886	9
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653)	0.874	9
UniProt:O14613 CDC42EP2	2	p-CDC42EP2 [cytosol] (R-HSA-5692662) CDC42EP2 [cytosol] (R-HSA-5692692)	0.83	10
UniProt:O96013 PAK4	1	PAK4 [cytosol] (R-HSA-428461)	0.825	5
UniProt:Q5VT25 CDC42BPA	1	CDC42BPA [cytosol] (R-HSA-419871)	0.815	6
GTP [ChEBI:15996]	7	GTP [cilium] (R-ALL-5617813) GTP [early endosome membrane] (R-ALL-2130170) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [Golgi membrane] (R-ALL-1806221)	0.797	8
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.794	10
UniProt:P52565 ARHGDIA	1	ARHGDIA [cytosol] (R-HSA-194478)	0.756	5
UniProt:Q9NPB6 PARD6A	4	PARD6A [plasma membrane] (R-HSA-418187) PARD6A [cytosol] (R-HSA-420001) PARD6A [cell junction] (R-HSA-2134480) p-S345-PARD6A [plasma membrane] (R-HSA-2134533)	0.755	7
UniProt:O00401 WASL	4	N-WASP [cytosol] (R-HSA-201873) p-Y256-WASL [cytosol] (R-HSA-2197672) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.75	4
UniProt:Q9P286 PAK5	2	PAK7 [plasma membrane] (R-HSA-211555) PAK5 [cytosol] (R-HSA-428459)	0.743	5
UniProt:Q9JK83	2	Pard6b [plasma membrane] (R-MMU-418193) Pard6b [cytosol] (R-MMU-419973)	0.729	6
UniProt:Q9NRR3 CDC42SE2	1	CDC42SE2 [plasma membrane] (R-HSA-9714853)	0.725	5
UniProt:Q13576 IQGAP2	3	IQGAP2 [plasma membrane] (R-HSA-6804811) IQGAP2 [secretory granule membrane] (R-HSA-6804779) IQGAP2 [cytosol] (R-HSA-5625975)	0.688	4
UniProt:Q9BYG4 PARD6G	2	PARD6G [plasma membrane] (R-HSA-418192) PARD6G [cytosol] (R-HSA-419967)	0.681	5
UniProt:P19878 NCF2	2	p-T233-NCF2 [phagolysosome] (R-HSA-1996211) NCF2 [cytosol] (R-HSA-1222600)	0.676	3
UniProt:P41743 PRKCI	3	PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [cytosol] (R-HSA-58206) PRKCI [plasma membrane] (R-HSA-420005)	0.67	5
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.668	9
UniProt:Q9UQB8-4 BAIAP2			0.667	4
UniProt:Q9NRR8 C42S1			0.659	3
UniProt:Q9NQU5 PAK6	1	PAK6 [cytosol] (R-HSA-428454)	0.659	4
UniProt:Q61036 Pak3	3	phospho-p-S154,T436-PAK3 [plasma membrane] (R-MMU-3928479) phospho-p-S154,T436-PAK3 [cytosol] (R-MMU-5357471) Pak3 [cytosol] (R-MMU-442833)	0.656	3
UniProt:Q86VI3 IQGAP3	1	IQGAP3 [cytosol] (R-HSA-5625977)	0.643	5
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.621	3
UniProt:Q92963 RIT1	1	RIT1 [plasma membrane] (R-HSA-187703)	0.619	6
UniProt:Q15642 TRIP10	1	TRIP10 [cytosol] (R-HSA-195120)	0.609	2
UniProt:O30916 SOPB			0.602	5
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.573	2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.564	2
UniProt:O52623 SOPE			0.558	2
UniProt:Q8WUI4-6 HDAC7			0.556	3
UniProt:Q00587-2 CDC42EP1			0.556	3
UniProt:B2RTY4 MYO9A	1	MYO9A [cytosol] (R-HSA-200628)	0.553	2
UniProt:Q9Y5S2 CDC42BPB	1	CDC42BPB [cytosol] (R-HSA-419873)	0.547	2
UniProt:P52306 RAP1GDS1	1	RAP1GDS1 [mitochondrial outer membrane] (R-HSA-9693756)	0.547	2
UniProt:P35268 RPL22	1	RPL22 [cytosol] (R-HSA-72428)	0.547	2
UniProt:Q9H3Q1 CDC42EP4	1	CDC42EP4 [cytosol] (R-HSA-9691381)	0.547	2
UniProt:Q16584 MAP3K11	1	MAP3K11 [cytosol] (R-HSA-449607)	0.536	3
UniProt:Q9VEX9	1	Bin1 [nucleoplasm] (R-DME-351694)	0.527	2
UniProt:P60660 MYL6	2	p-S20-MYL6 [cytosol] (R-HSA-445778) MYL6 [cytosol] (R-HSA-419186)	0.527	2
UniProt:Q9UHB6 LIMA1			0.527	2
UniProt:O15511 ARPC5	4	ARPC5 [secretory granule lumen] (R-HSA-6801071) ARPC5 [extracellular region] (R-HSA-6806476) ARPC5 [ficolin-1-rich granule lumen] (R-HSA-6801065) ARPC5 [cytosol] (R-HSA-200806)	0.527	2
UniProt:O08816 Wasl	1	N-Wasp [cytosol] (R-RNO-442543)	0.524	2
UniProt:P60953 CDC42	3	CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545)	0.524	2
UniProt:O95477 ABCA1	11	ABCA1 W590S [plasma membrane] (R-HSA-5682201) ABCA1 N935S [plasma membrane] (R-HSA-5682200) ABCA1 C1417R [plasma membrane] (R-HSA-5682190) ABCA1 S1446L [plasma membrane] (R-HSA-5682195) ABCA1 R587W [plasma membrane] (R-HSA-5682197) ABCA1 [plasma membrane] (R-HSA-194209) 4xPALM-C-p-2S-ABCA1 [plasma membrane] (R-HSA-5682069) 4xPALM-C-ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682085) 4xPALM-C-ABCA1 [plasma membrane] (R-HSA-5682091) ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682105) ABCA1 Q537R [plasma membrane] (R-HSA-5682199)	0.524	2
UniProt:Q96L34 MARK4	1	MARK4 [cytosol] (R-HSA-5626653)	0.499	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	11
UniProt:P45983 MAPK8	3	MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.483	2

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