Reactome | Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)

Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)

Stable Identifier

R-HSA-442724

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
        
        Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Homo sapiens)

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Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)

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CREB1 is phosphorylated at serine residue S133 by any of the three isoforms of ribosomal S6 kinase (RSK): RPS6KA1 (RSK1) (Song et al. 2003), RPS6KA2 (RSK3) (Schinelli et al. 2001), RPS6KA3 (RSK2) (De Cesare et al. 1998, Harum et al. 2001), and probably by RPS6KA6 (RSK4).

Literature References

PubMed ID	Title	Journal	Year
11160957	Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation Harum, KH, Johnston, MV, Alemi, L	Neurology	2001
9770464	Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene Jacquot, S, Hanauer, A, De Cesare, D, Sassone-Corsi, P	Proc Natl Acad Sci U S A	1998
11698596	Stimulation of endothelin B receptors in astrocytes induces cAMP response element-binding protein phosphorylation and c-fos expression via multiple mitogen-activated protein kinase signaling pathways Gallo, V, Paolillo, M, Zanassi, P, Schinelli, S, Feliciello, A, Wang, H	J. Neurosci.	2001
12842905	Induction of MUC8 gene expression by interleukin-1 beta is mediated by a sequential ERK MAPK/RSK1/CREB cascade pathway in human airway epithelial cells Chung, KC, Cho, KN, Seong, JK, Lee, WJ, Yoon, JH, Song, KS, Koo, JS, Kim, CH, Kang, CD	J. Biol. Chem.	2003