CREB1 is phosphorylated at serine residue S119 by any of the three isoforms of ribosomal S6 kinase (RSK): RPS6KA1 (RSK1) (Song et al. 2003), RPS6KA2 (RSK3) (Schinelli et al. 2001), RPS6KA3 (RSK2) (De Cesare et al. 1998, Harum et al. 2001), and probably by RPS6KA6 (RSK4).
Harum, KH, Johnston, MV, Alemi, L
Jacquot, S, Hanauer, A, De Cesare, D, Sassone-Corsi, P
Gallo, V, Paolillo, M, Zanassi, P, Schinelli, S, Feliciello, A, Wang, H
Chung, KC, Cho, KN, Seong, JK, Lee, WJ, Yoon, JH, Song, KS, Koo, JS, Kim, CH, Kang, CD
protein serine/threonine kinase activity of p-S221,T359,S363,S380,T573,T732-RSK [nucleoplasm]
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