Reactome | p-S113-CTTN [cytosol]

p-S113-CTTN [cytosol]

Stable Identifier

R-HSA-442842

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-Cortactin(S113)

Locations in the PathwayBrowser for interactor UniProt:P61158 ACTR3

Expand all

External Reference Information

External Reference

UniProt:Q14247 CTTN

Gene Names

CTTN, EMS1

Chain

chain:1-550

Reference Genes

BioGPS Gene:2017 CTTN

COSMIC (genes):CTTN CTTN

CTD Gene:2017 CTTN

dbSNP Gene:2017 CTTN

ENSEMBL:ENSG00000085733 CTTN

HGNC:3338 CTTN

KEGG:hsa:2017 CTTN

Monarch:2017 CTTN

NCBI Gene:2017 CTTN

OMIM:164765 CTTN

UCSC:Q14247 CTTN

Reference Transcript

Other Identifiers

11734776_a_at

11746740_a_at

11748448_a_at

16728389

201059_PM_at

201059_at

2017

214073_PM_at

214073_at

214074_PM_s_at

214074_s_at

3338551

3338553

3338558

3338560

3338561

3338562

3338563

3338564

3338565

3338566

3338567

3338568

3338572

3338574

3338575

3338576

3338577

3338578

3338579

3338583

3338584

3338585

3338586

3338587

3338588

3338589

3338590

3338591

3338592

3338593

3338594

3338595

3338596

3338597

3338599

3338600

3338601

3338604

3338607

3338609

3338610

3338611

3338612

3338613

3338614

3338615

3338616

3338617

3338618

39861_at

7942204

A_14_P130252

A_14_P134671

A_23_P202823

A_33_P3310780

A_33_P3392921

GE81480

GE847455

GE85025

GO:0001726

GO:0002102

GO:0005515

GO:0005522

GO:0005737

GO:0005783

GO:0005794

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005905

GO:0005925

GO:0005938

GO:0006886

GO:0006897

GO:0006898

GO:0006930

GO:0007010

GO:0007165

GO:0008076

GO:0016192

GO:0030027

GO:0030036

GO:0030139

GO:0030425

GO:0030426

GO:0030516

GO:0030838

GO:0030863

GO:0031410

GO:0034330

GO:0042995

GO:0043197

GO:0043226

GO:0043231

GO:0045202

GO:0045296

GO:0045987

GO:0048041

GO:0048812

GO:0048870

GO:0070161

GO:0097062

GO:0097191

GO:0097581

GO:1901524

GO:1990023

GO:2001237

HMNXSV003023968

HMNXSV003054614

Hs.119257.2.S1_3p_a_at

Hs.119257.2.S1_3p_at

ILMN_1744912

ILMN_1798838

ILMN_2393712

M98343_at

PH_hs_0023607

TC11000727.hg

g4885204_3p_at

Participates

as an output of

PAK phosphorylates cortactin (Homo sapiens)

Other forms of this molecule

CTTN [cytosol]

Modified Residues

Name

O-phospho-L-serine at 113

Coordinate

113

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_612632.1, NP_001171669.1, NP_005222.2

OpenTargets

ENSG00000085733

ENSEMBL

ENSP00000500756, ENST00000301843, ENSP00000500927, ENST00000376561, ENSP00000365745, ENSP00000301843, ENST00000346329, ENST00000671805, ENSP00000317189, ENST00000672198, ENST00000671849, ENSP00000499998

HPA

ENSG00000085733-CTTN

PRO

Q14247

Pharos - Targets

Q14247

GlyGen

Q14247

PDB

1X69, 2D1X

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9ULH1 ASAP1	1	ASAP1 [cytosol] (R-HSA-5620905)	0.765	7
UniProt:Q9UBN7 HDAC6	4	HDAC6 [lysosomal lumen] (R-HSA-9660002) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [nucleoplasm] (R-HSA-351589)	0.721	5
UniProt:P50570 DNM2	5	DNM2 [Golgi membrane] (R-HSA-2980842) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [cytosol] (R-HSA-2213180) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [plasma membrane] (R-HSA-2984201)	0.645	5
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.643	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.635	4
UniProt:Q08460 Kcnma1	2	Kcnma1 [plasma membrane] (R-MMU-9667781) KCNMA1 [plasma membrane] (R-MMU-418462)	0.591	3
UniProt:B7UM99 TIR			0.544	3
UniProt:P21333 FLNA	3	FLNA [extracellular region] (R-HSA-350712) p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [cytosol] (R-HSA-210019)	0.527	2
UniProt:Q16643 DBN1	1	DBN1 [cytosol] (R-HSA-9714666)	0.527	2
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.527	2
UniProt:P47755 CAPZA2	2	CAPZA2(265-276) [extracellular region] (R-HSA-879417) CAPZA2 [cytosol] (R-HSA-879448)	0.527	2
UniProt:P61160 ACTR2	4	ACTR2 [ficolin-1-rich granule lumen] (R-HSA-6800937) ACTR2 [extracellular region] (R-HSA-6806232) ACTR2 [azurophil granule lumen] (R-HSA-6798740) ACTR2 [cytosol] (R-HSA-200810)	0.527	2
UniProt:Q9QWI6-2 SRCIN1			0.499	2
UniProt:Q9JIY2	1	Cbll1 [cytosol] (R-MMU-8851646)	0.499	8
UniProt:P61158 ACTR3	1	ACTR3 [cytosol] (R-HSA-200811)	0.491	2
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.483	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	14
UniProt:P42768 WAS	2	p-Y291-WAS [cytosol] (R-HSA-2197668) WAS [cytosol] (R-HSA-201879)	0.463	3

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