Reactome | NUMB [plasma membrane]

NUMB [plasma membrane]

Stable Identifier

R-HSA-443595

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Protein numb homolog, NUMB_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P49757 NUMB

Gene Names

NUMB, C14orf41

Chain

chain:1-651

Reference Genes

BioGPS Gene:8650 NUMB

COSMIC (genes):NUMB NUMB

CTD Gene:8650 NUMB

dbSNP Gene:8650 NUMB

ENSEMBL:ENSG00000133961 NUMB

ENSEMBL_homo_sapiens_GENE:ENSG00000133961.21 NUMB

HGNC:8060 NUMB

KEGG Gene (Homo sapiens):8650 NUMB

Monarch:8650 NUMB

NCBI Gene:8650 NUMB

OMIM:603728 NUMB

UCSC:P49757 NUMB

Reference Transcript

Other Identifiers

11717946_x_at

11717947_a_at

11741062_s_at

11741063_a_at

11751092_s_at

207545_PM_s_at

207545_s_at

209073_PM_s_at

209073_s_at

3571342

3571343

3571345

3571348

3571349

3571350

3571351

3571352

3571353

3571354

3571356

3571360

3571363

3571366

3571367

3571369

3571371

3571373

3571377

3571378

3571386

3571390

3571392

37693_at

7980005

8650

A_23_P88381

GE57760

GO:0005515

GO:0005737

GO:0005768

GO:0005769

GO:0005886

GO:0005905

GO:0005925

GO:0007399

GO:0007405

GO:0007409

GO:0008013

GO:0010008

GO:0016020

GO:0016192

GO:0016323

GO:0021670

GO:0021849

GO:0030136

GO:0030154

GO:0030335

GO:0030900

GO:0031410

GO:0034330

GO:0034332

GO:0043226

GO:0045177

GO:0045294

GO:0045296

GO:0048856

GO:0048870

GO:0050769

GO:0072659

GO:0098978

GO:0099149

GO:1903077

HMNXSV003014490

HMNXSV003040684

ILMN_1705114

ILMN_2331266

L40393_at

PH_hs_0026037

PH_hs_0033520

TC14001288.hg

g4102704_3p_a_at

g4505478_3p_a_at

p19339

p33770

Participates

as a protein marker of

keratinocyte stem cell of skin epidermis basal layer (Homo sapiens)

as a component of

as an input of

Inferred To

Ghost homologue of NUMB [plasma membrane] (Drosophila melanogaster)

NUMB [plasma membrane] (Bos taurus)

NUMB [plasma membrane] (Canis familiaris)

NUMB [plasma membrane] (Gallus gallus)

NUMB [plasma membrane] (Sus scrofa)

Numb [plasma membrane] (Mus musculus)

Numb [plasma membrane] (Rattus norvegicus)

numb [plasma membrane] (Danio rerio)

numb [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001307043.1, NP_003735.3, NP_001005744.1, NP_001005743.1, NP_001005745.1

OpenTargets

ENSG00000133961

GeneCards

P49757

HPA

ENSG00000133961-NUMB

Ensembl

ENSP00000441258, ENST00000356296, ENSP00000453209, ENSP00000452416, ENSP00000451625, ENST00000557597, ENSG00000133961, ENSP00000348644, ENST00000554546, ENST00000554521, ENST00000559312, ENST00000555394, ENST00000535282, ENST00000555238, ENSP00000446001, ENST00000355058, ENST00000555738, ENSP00000352563, ENSP00000451300, ENST00000544991, ENSP00000450817, ENST00000560335, ENSP00000347169, ENSP00000452888, ENSP00000451117, ENST00000359560, ENSP00000452069

PRO

P49757

Pharos - Targets

P49757

PDB

5NJK, 5NJJ

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42566 EPS15	2	p-Y849 EPS15 [cytosol] (R-HSA-8867028) EPS15 [cytosol] (R-HSA-182920)	0.75	6
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.718	7
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.643	6
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.632	5
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.571	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.569	4
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.569	4
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.569	3
UniProt:P63010 AP2B1	4	AP2B1 [endolysosome membrane] (R-HSA-6784827) AP2B1 [plasma membrane] (R-HSA-167690) AP2B1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130489) AP2B1 [cytosol] (R-HSA-182166)	0.527	4
UniProt:Q10567 AP1B1	5	AP1B1 [cytoplasmic vesicle membrane] (R-HSA-351181) AP1B1 [Golgi membrane] (R-HSA-350809) AP1B1 [lysosomal membrane] (R-HSA-432699) AP1B1 [trans-Golgi network membrane] (R-HSA-2130596) AP1B1 [cytosol] (R-HSA-167705)	0.527	4
UniProt:P61962 DCAF7	2	DCAF7 [nucleoplasm] (R-HSA-8863312) Unfolded DCAF7 [cytosol] (R-HSA-6813821)	0.508	2
UniProt:Q96D71 REPS1	1	REPS1 [cytosol] (R-HSA-8862265)	0.499	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.499	2
UniProt:P35568 IRS1	5	p-Y-IRS1 [plasma membrane] (R-HSA-198366) p-Y-IRS1 [cytosol] (R-HSA-74772) IRS1 [cytosol] (R-HSA-74769) IRS1 [plasma membrane] (R-HSA-2425392) p-6Y-IRS1 [plasma membrane] (R-HSA-2445090)	0.488	2
UniProt:O43559 FRS3	3	p-5Y-FRS3 [plasma membrane] (R-HSA-191475) FRS3 [plasma membrane] (R-HSA-191482) p-Y-FRS3 [plasma membrane] (R-HSA-9032427)	0.488	2
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.483	2
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.463	2

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