Reactome | STIP1 [cytosol]

STIP1 [cytosol]

Stable Identifier

R-HSA-443857

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Stress-induced-phosphoprotein 1, STIP1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9C004 SPY4

Expand all

External Reference Information

External Reference

UniProt:P31948 STIP1

Gene Names

STIP1

Chain

chain:1-543

Reference Genes

BioGPS Gene:10963 STIP1

COSMIC (genes):STIP1 STIP1

CTD Gene:10963 STIP1

dbSNP Gene:10963 STIP1

ENSEMBL:ENSG00000168439 STIP1

ENSEMBL_homo_sapiens_GENE:ENSG00000168439.17 STIP1

HGNC:11387 STIP1

KEGG Gene (Homo sapiens):10963 STIP1

Monarch:10963 STIP1

NCBI Gene:10963 STIP1

OMIM:605063 STIP1

UCSC:P31948 STIP1

Reference Transcript

Other Identifiers

10963

11743041_a_at

11743042_a_at

16726224

207_at

212009_PM_s_at

212009_s_at

213330_PM_s_at

213330_s_at

3334225

3334226

3334227

3334228

3334231

3334234

3334235

3334236

3334238

3334239

3334240

3334241

3334242

3334244

3334245

3334246

3334248

3334250

3334251

4014309

4014313

7940857

A_24_P327815

GE58119

GO:0003723

GO:0005515

GO:0005634

GO:0005737

GO:0005794

GO:0005829

GO:0032991

GO:0043226

GO:0051879

GO:0098761

GO:0101031

GO:0120293

Hs.75612.1.A1_3p_a_at

Hs.75612.2.A1_3p_a_at

ILMN_1789510

M86752_at

PH_hs_0023292

TC11000585.hg

Participates

as a member of

RND1 effectors [cytosol] (Homo sapiens)

as an output of

as an input of

STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Homo sapiens)

as a component of

Inferred To

STI1 [cytosol] (Saccharomyces cerevisiae)

LOC119875949 [cytosol] (Canis familiaris)

STIP1_MOUSE [cytosol] (Mus musculus)

Stip1 [cytosol] (Drosophila melanogaster)

Stip1 [cytosol] (Rattus norvegicus)

stip1 [cytosol] (Danio rerio)

stip1 [cytosol] (Xenopus tropicalis)

Homologues of STIP1 [cytosol] (Dictyostelium discoideum)

sti1 [cytosol] (Dictyostelium discoideum)

sti1 [cytosol] (Schizosaccharomyces pombe)

STIP1 [cytosol] (Bos taurus)

STIP1 [cytosol] (Dictyostelium discoideum)

STIP1 [cytosol] (Gallus gallus)

STIP1 [cytosol] (Plasmodium falciparum)

STIP1 [cytosol] (Sus scrofa)

sti-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001269581.1, NP_001269582.1, NP_006810.1

OpenTargets

ENSG00000168439

GeneCards

P31948

HPA

ENSG00000168439-STIP1

Ensembl

ENSP00000305958, ENST00000358794, ENST00000305218, ENST00000538945, ENSP00000351646, ENSP00000445957, ENSG00000168439

PRO

P31948

Pharos - Targets

P31948

PDB

1ELR, 2NC9, 3ESK, 2LNI, 3FWV, 7KW7, 1ELW

Interactors (41)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.832	7
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.759	6
UniProt:Q8IWD4 CC117			0.708	5
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.666	4
UniProt:Q58FF6 H90B4			0.643	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.635	3
UniProt:P53041 PPP5C	2	PPP5C [cytosol] (R-HSA-5675402) PPP5C [nucleoplasm] (R-HSA-5683410)	0.623	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	9
UniProt:P04150 NR3C1	3	SUMO1-K277,K293-NR3C1 [nucleoplasm] (R-HSA-4341106) NR3C1 [cytosol] (R-HSA-5618118) NR3C1 [nucleoplasm] (R-HSA-879837)	0.61	5
UniProt:O15484 CAPN5	1	CAPN5 [cytosol] (R-HSA-8848642)	0.589	2
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.573	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.569	8
UniProt:Q13451 FKBP5	2	FKBP5 [cytosol] (R-HSA-5618096) FKBP5 [nucleoplasm] (R-HSA-8939165)	0.564	2
UniProt:Q9C004 SPY4			0.556	3
UniProt:Q3SXR2 CC036			0.556	3
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.556	3
UniProt:Q3SYB3 FX4L6			0.556	3
UniProt:Q14181 POLA2	1	POLA2 [nucleoplasm] (R-HSA-68493)	0.556	3
UniProt:P54274-2 TERF1			0.556	3
UniProt:O00463 TRAF5			0.556	3
UniProt:O00423 EMAL1			0.556	3
UniProt:O95674 CDS2	1	CDS2 [mitochondrial inner membrane] (R-HSA-1498755)	0.556	3
UniProt:Q8IZU1 FAM9A			0.556	3
UniProt:Q6DHV7-2 Q6DHV72			0.556	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.556	3
UniProt:Q06547-3 GABPB1	1	NRF2 gamma-1 subunit [nucleoplasm] (R-HSA-1592216)	0.556	3
UniProt:Q9NYQ3 HAO2	2	HAO2 [cytosol] (R-HSA-9033093) HAO2 [peroxisomal matrix] (R-HSA-6787806)	0.527	2
UniProt:Q8N1V2 CFA52			0.527	2
UniProt:Q99615 DNAJC7	2	DNAJC7 [cytosol] (R-HSA-5252099) DNAJC7 [nucleoplasm] (R-HSA-5255408)	0.527	2
UniProt:Q58FG1 HS904			0.527	2
UniProt:Q8N7C3 TRIMM			0.527	2
UniProt:Q58FG0 HS905			0.527	2
UniProt:Q7Z6J8 UBE3D	1	UBE3D [cytosol] (R-HSA-8851647)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q8N239 KLH34			0.527	2
UniProt:Q6UXT9 ABH15			0.527	2
UniProt:Q9Y6J9 TAF6L	1	TAF6L [nucleoplasm] (R-HSA-212393)	0.527	3
UniProt:O75190 DNAJB6	2	DNAJB6 [cytosol] (R-HSA-5252014) DNAJB6 [nucleoplasm] (R-HSA-5255425)	0.527	2
UniProt:Q7Z6Z6 PNPLA5	1	PNPLA5 [cytosol] (R-HSA-8848346)	0.527	3
UniProt:Q96AP0 ACD	1	ACD [nucleoplasm] (R-HSA-174889)	0.508	2
UniProt:Q7L3B6 CDC37L1	2	CDC37L1 [extracellular region] (R-HSA-8848918) CDC37L1 [platelet dense granule lumen] (R-HSA-8848903)	0.499	2