Reactome | SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow

SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow

Stable Identifier

R-HSA-443905

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow

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In a mechanism that is presumed to be analagous to signaling of SHC downstream of the insulin and TrkA receptors, SHC becomes phosphorylated and dissociates from the integrin alphaIIb beta3 complex.

Literature References

PubMed ID	Title	Journal	Year
8755247	Not all Shc's roads lead to Ras Pelicci, G, Bonfini, L, Migliaccio, E, Lanfrancone, L, Pelicci, PG	Trends Biochem Sci	1996
10964917	Identification of shc as the primary protein binding to the tyrosine-phosphorylated beta 3 subunit of alpha IIbbeta 3 during outside-in integrin platelet signaling Phillips, DR, Cowan, KJ, Law, DA	J Biol Chem	2000